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  • 1
    Electronic Resource
    Electronic Resource
    The anti-inflammatory properties of isoxicam (4-hydroxy-2-methyl-N-[5-Methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide]) (1975)
    Springer
    Inflammation research 5 (1975), S. 256-263 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isoxicam is a potent, orally active, nonsteroidal anti-inflammatory drug with prolonged activity in experimentally induced inflammation in rats. Isoxicam is less ulcerogenic, acutely less toxic and, therefore, appears to have a therapeutic ratio superior to other standard agents to which it was compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026440
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  • 2
    Electronic Resource
    Electronic Resource
    Fetal Isoenzyme Expression in Human Tumor Xenografts (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been shown previously that a human cancer cell line (HeLa TCRC-1) which produces only the Regan isoenzymes of alkaline phosphatase in culture, elaborates a different isoenzyme form when grown in an animal host. This alteration of isoenzyme expression results in the production of an isoenzyme form referred to as oncoamniotic (FL), since it shares many of the characteristics of the enzyme form produced by the FL amnion cell line.Here we shall report on the alteration of isoenzyme expression in a non-Regan producing cell line heterotransplanted into an immunosuppressed animal host. HeLa TCRC-2 is a cell line cloned for the exclusive production of an isoenzyme form which is most similar to adult bone type alkaline phosphatase. This cell line growing in an animal host produces an additional isoenzyme form which appears to be similar to the amniotic (FL) type. The original non-Regan alkaline phosphatase of this cell line persists, and is co-expressed during in vivo growth.When HeLa TCRC-2 is removed from the animal and placed back into culture, the exclusive production of the adult bone type alkaline phosphatase is restored.The present report indicates the dramatic alterations in gene expression observed when well characterized cultured cells are heterotransplanted into immunosuppressed animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb03976.x
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  • 3
    Electronic Resource
    Electronic Resource
    Metastasierendes Ameloblastom im Kindesalter (1979)
    Springer
    Virchows Archiv 381 (1979), S. 211-222 
    Details
    ISSN: 1432-2307
    Keywords: Ameloblastoma ; Metastases ; Light and Electron Microscopy ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a 5 1/2 years old boy with a plexiform ameloblastoma of the jaw is reported. 6 years after resection of the primary tumor metastases developed in a lymph node at the left side of the neck and in both lungs. Thoracotomy revealed many small metastases spread all over the lungs. Light and electron microscopical studies of the primary tumor showed a typical plexiform ameloblastoma without signs of malignancy. In the metastases, however, these studies revealed the histological criteria of a malignant tumor with marked pleomorphism of tumor cells, increase of heterochromatin, enlargement of nucleoli and invagination of nuclear membranes. After enucleation of two metastases and therapy with cytostatic agents for several months no further metastases have been observed within a period of 6 years. Comparative light and electron microscopic studies of both primary tumor and metastases demonstrate that there are no histological criteria to identify the primary tumor as a malignant ameloblastoma. Ameloblastoma with distant metastases is a rare tumor in children, this case is only the third reported in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257886
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  • 4
    Electronic Resource
    Electronic Resource
    Therapieergebnisse beim verhornenden Zungen-Carcinom nach Kombinationsbehandlung mit Methotrexat, Bleomycin sowie Nucleosiden (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 223 (1979), S. 477-478 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prognosis of inoperable squamous cell carcinoma of the tongue (T3, N0–3) was because of low ray-sensibility mostly unfavorable. The combined therapy with methotrexate and bleomycin and nucleosides (inosine and thymidine) show new therapeutic possibilities. Since 1975 the combined therapy was used in more than 25 cases. The favorable effect was attributed to the ability of the nucleosides, thymidine and inosine, to reduce toxicity. In most of the cases we reached operability of the tumor (T1–2, N0–2), in several cases we achieved clinical and histological full remission of the tumor. The best treating-scheme of nonoperable squamous cell carcinoma of the tongue will be the combined cytostaticanucleoside-treating, the sequential complete excession of the tumor followed by radiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01109640
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  • 5
    Electronic Resource
    Electronic Resource
    Klassifikation der arbeitszufriedenheit und des subjektiven belastungs- und gesundheitsstatus von fluglotsen (1977)
    Springer
    International archives of occupational and environmental health 39 (1977), S. 1-26 
    Details
    ISSN: 1432-1246
    Keywords: Health status ; Stress ; Job-satisfaction ; Rank of importance ; Cluster analysis. ; Gesundheitsstatus ; Belastungsempfinden ; Arbeitszufriedenheit ; Bedeutungsrangfolge ; Clusteranalyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine Vollerhebung der sozialpsychologischen Situation von Fluglotsen (N = 517) mit nominalstatistischen Daten wurde clusteranalytisch ausgewertet. Das Ergebnis der multivariaten Analyse wurde unter methodischen und inhaltlichen Aspekten mit univariaten Auswertungen von Singer und Rutenfranz (1972) verglichen: Cluster zur personalen Umgebung spezifizieren Aussagen zum typischen Lotsen. Mittlere Bedeutungsrangfolgen zu Variablen der Arbeitssituation werden in Gruppen gegenteiliger Meinung aufgelöst und in Beziehung zur Arbeitszufriedenheit gebracht. Gruppen von Lotsen mit guter Zufriedenheit werden von stark unzufriedenen separiert. Aussagen zur negativen Einschätzung des gesamten Berufsweges werden durch Cluster belegt, besondere Probleme einzelner Dienstorte herausgefiltert. Die Gesamtheit der Lotsen wurde nach subjektivem Gesundheitsstatus mit Krankheitssymptomen und therapeutischen Maßnahmen gegliedert. Beziehungen zwischen Gesund-heitsstörungen, Arbeitsunzufriedenheit, Belastung und Bedeutungsgewichtung von Aspekten der Arbeitssituation werden aufgezeigt und teilweise durch Motivations-und Zufriedenheitstheorien erklärt.
    Notes: Summary A total inventory about the sociopsychological situation of german air-traffic controllers (N = 517) with data on nominal scales was analysed by cluster analysis. The results of the multivariate analysis were compared with those of univariate analysis by Singer and Rutenfranz (1972) in methodology and substance: Clusters concerning the family situation specify statements to the “typical controller”. Mean rankings of importance of variables of the work-situation are split into groups of contradictory meanings and are related to job satisfaction. Groups of controllers with good job satisfaction are separated from the dissatisfied. Negative estimations of the career are substantiated by clusters. Special problems of some airports are filtered out. The collectif of all air traffic controllers is structured according to subjective health status, symptoms of illness and therapeutics. Relations between health disturbances and job satisfaction, stress and rankings of importance of aspects of work situation are pointed out and partially explained with motivation- and job-satisfaction theories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381547
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  • 6
    Electronic Resource
    Electronic Resource
    Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1301-1302 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Folic acid was estimated in blood and seminal plasma of normo- and oligospermic men. Following folic acid administration (10 mg TID for 30 days), the levels in blood and semen increased. However, sperm counts, motility and DNA content of spermatozoa were not affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01981432
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  • 7
    Electronic Resource
    Electronic Resource
    Control of gene expression in blue-green algae (1975)
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 650-651 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To establish whether any controls at the level of gene expression have evolved in blue-green algae, it seems pertinent to look for responses to environmental stimuli which do affect the growth of these organisms. Such stimuli include CO2, sources of phosphorus and nitrogen, and, of course, light. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/253650a0
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  • 8
    Electronic Resource
    Electronic Resource
    Nalidixic acid causes a transient G1 arrest in the yeast Saccharomyces cerevisiae (1979)
    Springer
    Molecular genetics and genomics 176 (1979), S. 37-39 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The addition of nalidixic acid to growing cells of the yeast Saccharomyces cerevisiae resulted in a transient depression in the rate of ribosomal precursor RNA production and a transient arrest of cells in G1. Protein synthesis rates were less affected. Lower concentrations of nalidixic acid also affected RNA synthesis and progression through G1 but had no effect on protein synthesis rates. We suggest that nalidixic acid has a primary effect on RNA synthesis leading to a G1 arrest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334293
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