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  • 1
    Electronic Resource
    Electronic Resource
    Tumor host relations (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 287-292 
    Details
    ISSN: 1432-1335
    Keywords: Plasma cortisol ; Tumor classification ; Breast ; Stomach ; Intestine ; Skin ; Gall bladder ; Lymph nodes ; Metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with tumors classified T2 according to the TNM scheme (+27% above the control). Highly significant increases were observed for T3 (+82%) and t4 (+77%) patients. Patients with palpable lymph nodes showed a most significantly increased cortisol mean value compared with patients without palbable lymph nodes. Similarly, the cortisol mean value of patients with distant metastases was significantly higher than the corresponding value of tumor patients without distant metastases. The question remains open, whether the primary site, the extent of the tumor or the occurrence of metastases is the main determinant for the cortisol increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964585
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tumor host relations (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 293-300 
    Details
    ISSN: 1432-1335
    Keywords: α-ketoglutarate ; Blood ; Urine ; Serum albumin ; Walker carcinoma 256 ; Yoshida sarcoma ; Rhabdomyosarcoma ; Tumor bearer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Referring to the increased α-ketoglutarate (I) concentration in blood of cancer-bearing humans, the concentration of (I) in blood and of albumin (II) in serum were measured in 85 tumor-bearing and control rats by fluorimetry and cellulose acetate electrophoresis, respectively. (I) was elevated on the average by a factor of 1.82 and (II) was decreased by a factor of 0.73 in rats bearing the solid Rhabdomyosarcoma BA 1112 and the ascitic or solid forms of Walker-carcinoma 256 and Yoshida-sarcoma compared with tumor-free animals. All deviations were found to be statistically significant for the different tumor types, with the exception of the increase of (I) in Walker-ascites tumor-bearing rats. For rats bearing the ascitic and solid Yoshida-sarcoma and the ascitic Walker-carcinoma 256 and for tumor-free rats a negative correlation could be observed between increase of (I) and decrease of (II). The increase of (I) in blood was paralleled by an increased excretion rate of (I) into urine. In rats bearing the solid Yoshida-sarcoma the daily excreted amount of (I) was significantly increased by a factor of 1.86 compared with tumor-free animals. The excretion of (I) was already increased in the first week after tranplantation, remained constant for two more weeks and decreased sharply below normal values prior to death. The results suggest that rats bearing the inquested tumors are suitable models for metabolic studies on causes of pathological concentrations of (I) in blood of cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964586
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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