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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 173 (1978), S. 67-87 
    ISSN: 1433-8580
    Keywords: Colloidal perfusate ; Edema formation ; Survival ; Kolloidales Perfusat ; Ödembildung ; Überleben
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 31 Hunden wurde in Hypothermie ein totaler Blutaustausch (HKT 〈 1%) mit kristalloidem oder kolloidhaltigem Perfusat durchgeführt. Austausch und Kühlung erfolgten mittels partieller, extracorporaler Zirkulation und Wäremeaustauscher. Die Überlebensrate der Tiere betrug nach Blutaustausch mit kristalloidem Perfusat ohne Kreislaufstillstand 66%. Wurde zusätzlich ein Kreislaufstillstand von 30 min bei 14°C induziert, verstarben alle vier Tiere bei generalisiertem interstitiellen Ödem; die mittlere Überlebenszeit betrug 19 Stunden. Bei Blutaustausch gegen kolloidhaltiges Perfusat (2,5% Dextran 60) betrug die Überlebensrate nach Kreislaufstillstand von 30 bzw. 60 min 71 bzw. 50%. Durch die Anwendung des kolloidhaltigen Perfusates konnte die Ödementwicklung weitgehend verhindert werden. Der Tod der Tiere konnte durch die gemessenen Parameter nicht erklärt werden.
    Notes: Summary Total body washout (hct 〈 1%) in hypothermia was performed in 31 dogs using either a crystalloidal or a colloidal perfusate. Blood exchange and cooling was achieved by means of partial bypass and heat exchanger. Short lasting blood exchange for crystalloids without cardiac arrest resulted in 66% survival of the animals. When in addition circulatory arrest was established for 30 min at 14°C oesophageal temperature blood exchange for crystalloids was not tolerated. All four animals of this group died within 19 hours presenting massive interstitial edema. Replacement of the crystalloidal perfusate by a colloidal solution (2.5g% Dextran 60 in Ringer's Lactate) and establishing circulatory for 30 or 60 min resulted in survival rates of 71% and 50% respectively. The use of the colloidal perfusate effectively prevented edema formation. Death could not be correlated with the parameters controlled.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Oxygen transport ; oxygen release capacity ; tissue oxygenation ; intravascular presistence ; transcapillary leakage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present status of stromafree haemoglobin solution does not allow its application as a blood replacement fluid in patients. Although there is conclusive evidence of no renal toxicity there are two basic disadvantages: 1. Insufficient intravascular persistence and significant transcapillary leakage; 2. Increased oxygen affinity of haemoglobin solution as compared to red cell haemoglobin. It is concluded that the original haemoglobin molecule has to be modified chemically to fullfil both requirements. Studies with crosslinked haemoglobin products have shown that the ideal solution for the near future probably consists of a compromise: The haemoglobin molecule should be crosslinked to other colloids to improve its intravascular persistence; the connection, however, should be flexible enough to allow the physiologic mobility and interaction of the four polypeptide chains necessary for proper oxygen binding and release characteristics.
    Type of Medium: Electronic Resource
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