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  • 2005-2009  (1)
  • 1970-1974  (14)
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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To document the clinical, histological, immunohistochemical and ultrastructural features of three malignant melanomas showing neuroendocrine differentiation.Methods and results : Three patients, two with primary cutaneous melanoma and one with nasal mucosal melanoma, subsequently developing or simultaneously presenting with metastatic malignant melanoma, were studied by conventional histological technique, immunohistochemistry of formalin-fixed paraffin-wax embedded tissues, and electron microscopy of epoxy-resin-embedded tumour tissue. Tumours showed either small cell or conventional malignant melanoma cell morphology. One of the three primary melanocytic lesions (the nasal melanoma) exhibited neuroendocrine differentiation immunohistochemically. All three metastatic malignant melanomas showed, in varying combinations, immunohistochemical and ultrastructural evidence for neuroendocrine differentiation: they were positive for the melanocytic markers, S100 protein, HMB-45, Melan-A and tyrosinase, and the neuroendocrine markers chromogranin, synaptophysin and neurofilament protein. Ultrastructural study in two of the metastases revealed neuroendocrine granules but no lattice-bearing melanosomes.Conclusions : The cases described are the most comprehensively investigated malignant melanomas showing neuroendocrine differentiation to date, and the first to document neuroendocrine differentiation ultrastructurally in these tumours. Malignant melanoma with neuroendocrine differentiation therefore needs to be recognized among the other, better known variants of malignant melanoma.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 19 (1972), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. The temporal separation of macromolecular syntheses from protein assembly into microtubular structures has permitted the use of the Stentor ciliated oral membranellar band regenerating system as an assay for mitotic spindle inhibitors (Banerjee & Margulis, 1971). Melatonin, the pineal gland hormone, is additive to Colcemid in this assay; like Colcemid it specifically inhibits band migration as a sensitive function of developmental stage and concentration. Altho the entire process of band formation and cilia regeneration (stages 0–8) is inhibited by melatonin, stage 3 is especially sensitive.Delay in morphogenesis at stage 3 can be measured as a precise function of inhibitors (Colcemid, podophyllotoxin, melatonin) of the form y=kxn, where y is delay in hours and k is the concentration of inhibitor in moles. Riboflavin (0.2 μM) and nicotinamide (0.2 μM) in combination reversed Colcemid-induced delay in band regeneration, but (unlike melatonin) the vitamins alone were totally without effect on the regenerating system. Therefore melatonin probably interacts with microtubule protein whereas the B vitamins interact in some way with Colcemid to nullify its activity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 17 (1970), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS Stentor coeruleus, induced to shed their ciliary membranellar bands, regenerate these and associated oral structures within a few hours after treatment. In cells placed in media containing optimal concentrations of mitotic spindle inhibitors, regeneration of the ingestive organelles is reversibly inhibited. Inhibitory effects of Colcemid, podophyllotoxin, and cold temperature reported here are compared with previous results using colchicine, griseofulvin and isopropyl-n-phenyl carbamate on regenerating oral membranellar cilia and cell growth.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Earth and Planetary Sciences 1 (1973), S. 269-296 
    ISSN: 0084-6597
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 745-746 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In support of Robinson's interpretation we present more evidence for cooperative interactions between the Na+ binding sites of this enzyme. In the presence of Mg2+ and Pi a readily reversible binding of 3H-ouabain to this enzyme was observed7,8. The equilibrium level of this binding was ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 7 (1974), S. 113-120 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wird die nichtstationäre Wärmeleitung in einer in Öl abgeschreckten Kugel untersucht unter besonderer Berücksichtigung des Einflusses von Radius und Wärmeleitfähigkeit der Kugel (Biot-Zahl) auf die Oberflächentemperatur. Das Problem ist hochgradig nichtlinear wegen der starken Abhängigkeit des Wärmeübergangskoeffizienten von der Oberflächentemperatur. Wärmeleitgleichung und Randbedingung werden in eine einzelne nichtlineare Volterra-Integralgleichung zweiter Art für die Oberflächentemperatur transformiert, die numerisch durch eine modifizierte schrittweise Approximation mit getrennter Näherung für den Kern gelöst wird. Ergebnisse für eine Anfangstemperatur der Kugel von 1144 K bei Abkühlung auf 317 K in einem weiten Bereich der Biot-Zahl werden mit der Näherung für unendliche Wärmeleitfähigkeit verglichen. Die größte Temperaturdifferenz zwischen dieser Näherung und den genauen Resultaten beträgt 24 K, 64 K und 144 K für die entsprechenden Biot-Zahlen 0,1, 1,0 und 10.
    Notes: Abstract Transient heat conduction in a solid sphere quenched in oil is studied. Specifically, the influence of radius and thermal conductivity of the sphere (Biot number) on the surface temperature is investigated. The problem is extremely nonlinear because the heat transfer coefficient is a strong function of the surface temperature. In the analysis, the transient heat conduction equation and boundary conditions are transformed into a singular nonlinear Volterra Integral equation of the second kind for the surface temperature. This equation is solved numerically by a modified successive approximation method and a separable kernel approximation. Results for a sphere initially at 1144 K and cooled to 317 K are obtained over a wide range of Biot numbers and are compared with the infinite thermal conductivity approximation. The maximum difference between the infinite thermal conductivity approximation and the exact results is 24 K, 64 K, and 144 K for Biot numbers 0.1, 1.0, 10.0, respectively.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 713-714 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Nous avons étudié l'effet d'une l'illumination continue ou d'une obscurité de 7 jours sur le système hypothalamique neurosécréteur (HNS) du lézard des jardinsCalotes versicolor. L'illumination a stimulé le HNS par activation de la synthèse, du transport et de la libération de la neurohormone(s) tandis que l'obscurité a fait diminuer la quantité libérée de neurohormone de la pars nervosa.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1236-1237 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Susammenfassung Es wurde festgestellt, dass zwischen den Asparaginase-empfindlichen und resistenten Tumorzellen ein Unterschied bezüglich der Häufigkeit des Vorkommens von Marker-Chromosomen besteht.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 147-148 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Dans les reins et dans les tissus de tumeur un facteur provoquant une glutaminase a été mis en évidance. Cette activité est plus faible dans les reins. Le dialysat du rein accuse deux pH optima de 5.0 à 8.0, tandis que celui de la tumeur n'a qu'un pH optimum de 8.0.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 23 (1970), S. 59-62 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histochemical localizations of various substances in the hypothalamic neuro-secretory cells as well as neurohypophysis of the normal and stressed (scalded) garden lizards, Calotes versicolor suggest that the neurosecretory materials, secreted by the hypothalamic neurones may be a mucoprotein-lipoprotein complex which is finally stored in the neuro-hypophysis. Only the proteinaceous fraction of this complex appears to be released by the nerve terminals in the neurohypophysis under the stressed condition. Such suggestion implies a chemical transformation of neurosecretory substances after leaving the neurosecretory cell body.
    Type of Medium: Electronic Resource
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