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  • 1
    Electronic Resource
    Electronic Resource
    Quergestreifte Fibrillen in Schwannschen Zellen (1970)
    Springer
    Naturwissenschaften 57 (1970), S. 44-44 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593567
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Myelinated nerve fibre regeneration in diabetic sensory polyneuropathy: correlation with type of diabetes (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 403-410 
    Details
    ISSN: 1432-0533
    Keywords: Key words Diabetic neuropathy ; Axonal regeneration ; Nerve growth factor receptors ; Schwann cells ; Basal lamina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Observations were made on myelinated fibre regeneration in diabetic sensory polyneuropathy assessed in sural nerve biopsy specimens. These confirmed that regenerative clusters initially develop within abnormally persistent Schwann cell basal laminal tubes. The number of regenerating fibres, identified by light microscopy, was found to decline in proportion to the reduction in total myelinated fibre density. The relative number of regenerating fibres was significantly greater in patients with insulin-dependent as compared with those with non-insulin-dependent diabetes after correction for age. There was a slight negative correlation between the relative proportion of regenerating fibres and age, but this was not statistically significant. The progressive reduction in the number of regenerating fibres with declining total fibre density indicates that axonal regeneration fails with advancing neuropathy. The production of nerve growth factor (NGF) and NGF receptors by denervated Schwann cells is likely to be important for axonal regeneration. To investigate whether the failure of axonal regeneration could be related to a lack of NGF receptor production by Schwann cells, we examined the expression of p75 NGF receptors by Büngner bands immunocytochemically. In comparison with other types of peripheral neuropathy, p75 NGF receptor expression appeared to take place normally. It is concluded that failure of axonal regeneration constitutes an important component in diabetic neuropathy. Its explanation requires further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315014
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Paranodal structure in diabetic sensory polyneuropathy (1996)
    Springer
    Acta neuropathologica 92 (1996), S. 614-620 
    Details
    ISSN: 1432-0533
    Keywords: Key words Diabetic polyneuropathy ; Nodes of ; Ranvier ; Paranodes ; Axoglial dysjunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a characteristic feature of both human and experimental diabetic neuropathy and which has been related to paranodal swelling. In the present series of cases it was not possible to confirm that axoglial dysjunction is a distinctive feature of diabetic polyneuropathy in fibres not undergoing active demyelination or wallerian-type degeneration, neither was excessive paranodal enlargement found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050569
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral nerve abnormalities in the congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 165-170 
    Details
    ISSN: 1432-0533
    Keywords: Key words Peripheral neuropathy ; Hypomyelination ; Dysmorphism ; Cataracts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Observations have been made on the peripheral nerve changes in four patients, ranging in age from 4 to 32 years, with the congenital cataracts facial dysmorphism neuropathy syndrome. Myelinated fibre density was within normal limits. The salient abnormality was diffuse hypomyelination which, in the older patients, was associated with demyelination and then axonal degeneration. These findings could be correlated with the relative preservation of sensory action potential amplitude despite markedly reduced nerve conduction velocity. Unmyelinated axon density was preserved. The morphological observations suggest the operation of a developmental process affecting myelination with a later superimposed degenerative disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051065
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Myelinated nerve fibre regeneration in diabetic sensory polyneuropathy: correlation with type of diabetes (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 403-410 
    Details
    ISSN: 1432-0533
    Keywords: Diabetic neuropathy ; Axonal regeneration ; Nerve growth factor receptors ; Schwann cells ; Basal lamina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Observations were made on myelinated fibre regeneration in diabetic sensory polyneuropathy assessed in sural nerve biopsy specimens. These confirmed that regenerative clusters initially develop within abnormally persistent Schwann cell basal laminal tubes. The number of regenerating fibres, identified by light microscopy, was found to decline in proportion to the reduction in total myelinated fibre density. The relative number of regenerating fibres was significantly greater in patients with insulin-dependent as compared with those with non-insulin-dependent diabetes after correction for age. There was a slight negative correlation between the relative proportion of regenerating fibres and age, but this was not statistically significant. The progressive reduction in the number of regenerating fibres with declining total fibre density indicates that axonal regeneration fails with advancing neuropathy. The production of nerve growth factor (NGF) and NGF receptors by denervated Schwann cells is likely to be important for axonal regeneration. To investigate whether the failure of axonal regeneration could be related to a lack of NGF receptor production by Schwann cells, we examined the expression of p75 NGF receptors by Büngner bands immunocytochemically. In comparison with other types of peripheral neuropathy, p75 NGF receptor expression appeared to take place normally. It is concluded that failure of axonal regeneration constitutes an important component in diabetic neuropathy. Its explanation requires further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315014
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Diabetic neuropathies (1997)
    Springer
    Diabetologia 40 (1997), S. B74 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051409
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The examination of isolated nerve fibres by light and electron microscopy, with observations on demyelination proximal to neuromas (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 177-186 
    Details
    ISSN: 1432-0533
    Keywords: Isolated Nerve Fibres ; Electron Microscopy ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Technik zur Isolierung peripherer Nervenfasern durch Auffasern und nachfolgende licht-undd elektronenmikroskopische Untersuchung beschrieben. Diese Technik wurde zum Studium ungewöhnlich geschwollener Fasern angewandt, die proximal der Läsion bei durchschnittenen Nerven von Ratten beobachtet wurden. Diese Fasern wurden als das Ergebnis der Demyelinisation bereits remyelinisierter Segmente dargestellt.
    Notes: Summary A technique is described for isolating peripheral nerve fibres by teasing and subsequently examining them by light and electron microscopy. The technique was applied to the study of unusual swollen fibres observed central to the lesion in transected nerves in rats. These were shown to be the result of the demyelination of already remyelinated segments of the fibre.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687357
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Electron microscope observations on aberrant regeneration of unmyelinated axons in the vagus nerve of the rabbit (1971)
    Springer
    Acta neuropathologica 18 (1971), S. 150-159 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Nerve Regeneration ; Unmyelinated Axons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine elektronenmikroskopische Untersuchung über die Regeneration von marklosen Axonen wurde am N. vagus des Kaninchens durchgeführt. Als Folge einer lokalisierten Quetschverletzung des N. vagus am Hals in Höhe der Cartilago thyreoidea wurden die regenerierenden marklosen Axone in den laryngealen Recurrens-Ast abgelenkt, der normalerweise beinahe vollständig aus myelinreichen Fasern aufgebaut ist. Die regenerierenden marklosen Axone kommen um die regenerierenden myelinreichen Axone zu liegen, sind aber mit getrennten Schwannschen Zellen verbunden. Eine mögliche Erklärung für diese aberrierende Regeneration der myelinfreien Axone wird diskutiert, ebenso ihre Bedeutung für die Human-Neuropathologie.
    Notes: Summary An electron microscope investigation has been made into the regeneration of unmyelinated axons in the vagus nerve of the rabbit. Following a localized crush injury of the vagus nerve in the neck at the level of the thyroid cartilage, the regenerating unmyelinated axons become diverted into the recurrent laryngeal branch, which is normally composed almost entirely of myelinated fibres. Here the regenerating unmyelinated axons become arrayed around the regenerating myelinated axons, but are associated with separate Schwann cells. The possible explanation for this aberrant regeneration of the unmyelinated axons is discussed, as is its significance for human neuropathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687603
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Nerve biopsy findings in two cases of Tangier disease (1973)
    Springer
    Acta neuropathologica 26 (1973), S. 317-327 
    Details
    ISSN: 1432-0533
    Keywords: Peripheral Neuropathy ; Tangier Disease ; Schwann Cells ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve biopsy findings are recorded for two previously reported patients with Tangier disease (hereditary high density lipoprotein deficiency). Both cases showed unusual clinical manifestations in comparison with other reported cases. The neurological disorder, symptoms from which began in the third decade, gave rise to a lower motor neuron deficit of unique distribution, which was accompanied by progressive sensory impairment limited for many years to loss of pain and temperature sensibility, ultimately involving all sensory modalities. Both biopsy specimens displayed similar features, with a gross loss of unmyelinated and myelinated axons, an extensive accumulation of lipid within Schwann cells, and excessive endoneurial collagenization. The axonal loss appeared to represent a primary axonal degeneration, there being no evidence of a demyelinating process. It is suggested that the accumulation of cholesterol within Schwann cells may be the result of a failure of cholesterol removal mechanisms or of intracellular lipid transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688079
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    An epidemic of optic neuropathy and painful sensory neuropathy in Cuba: Clinical aspects (1995)
    Springer
    Journal of neurology 242 (1995), S. 629-638 
    Details
    ISSN: 1432-1459
    Keywords: Optic neuropathy ; Sensory peripheral neuropathy ; Cuban epidemic ; Nutritional deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An epidemic of bilateral optic neuropathy and painful sensory neuropathy occurred in Cuba in 1991–1993. Over 45 000 individuals were stated to have been affected. We report a clinical study on 25 patients seen in Cuba in 1993–1994. Affected patients showed either bilateral optic neuropathy with caecocentral scotomata or a distal predominantly sensory neuropathy sometimes associated with deafness, or a combination of both optic and peripheral sensory neuropathy. The nature of the epidemic is discussed. The clinical features in patients with confirmed neurological deficits were consistent with a diagnosis of Strachan's syndrome, probably related to nutritional deficiency. Other patients with similar symptoms showed no evidence either of optic or peripheral neuropathy and were considered to represent disease mimicry on a psychoneurotic basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866912
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    Paper (German National Licenses)
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