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  • 1970-1974  (12)
  • 1960-1964  (4)
  • Cell & Developmental Biology  (16)
  • 1
    Electronic Resource
    Electronic Resource
    The cytology of hofbauer cellsThis study was supported by grant 5 R01 HD-02613 from the National Institute of Child Health and Human Development. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 167 (1970), S. 231-251 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Cytological investigation of Hofbauer cells in various stages of gestation reveals that they are similar to normal macrophages except for unusually large cytoplasmic flanges and included vacuoles. The system of vacuoles is apparently the result of macropinocytotic activity. The individual vacuoles undergo asymmetrical collapse in regions adjacent to small juxtavacuolar tubules thought to be derived from the agranular endoplasmic reticulum. In addition, coated micropinocytotic vesicles are common. Hofbauer cells thus appear to be a type of macrophage with an unusual capacity for fluid ingestion. In younger placentas, Hofbauer cells are usually associated with extracellular compartments within the stroma. These compartments are relatively free of collagen fibrils and demonstrable ground substance and are clearly demarcated from the rest of the stroma by processes of fibroblasts. The abundance of these cells in early placentas, their location in the stroma, and evidence of their pinocytotic activity suggest that these cells may play a role in removal of proteins from interstitial fluid. Hofbauer-like cells were also studied in the guinea pig and the little brown bat. Of these two species, the Hofbauer-like cells of the bat more closely resemble human Hofbauer cells in that they show evidence of extensive macropinocytotic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091670211
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake of exogenous protein by the preimplantation rabbitThis investigation was supported by grant 2 RO1 HD04962 from The National Institute of Child Health and Human Development. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 179 (1974), S. 311-330 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A study of the uptake of exogenous proteins, peroxidase, ferritin, and myoglobin by rabbit blastomeres of different developmental stages was undertaken to determine some of the means by which these stages ingest protein. Exposure of embryos in preimplantation stages, ranging from fertilized ovum to late blastocyst, was carried out in vitro with selected in vivo controls. Blastomeres of early cleavage stages up to the morula show little uptake of peroxidase. However, the endocytosis of peroxidase greatly increases with the morula stages and continues at an elevated level through the blastocyst stages. The uptake of the tracer is initially accomplished via micropinocytotic vesicles and tubules and can have several subsequent fates. The tracer can pass into larger vacuoles and be transported into the cavity of the blastocyst, or can pass into multivesicular bodies where it is presumably degraded by the lysosomal system for cellular use. The use of myoglobin at selected blastocyst stages yielded results similar to those obtained with peroxidase. However, the response by the blastomeres to ferritin is different. Endocytosis of ferritin is scant at all preimplantation stages, even though the ferritin has no difficulty reaching the surface of the blastomeres. The experiment with mechanically denuded blastocysts indicated that ferritin did not adsorb to the cell surface.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091790304
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative studies on the endometrium of delayed implantationSupported by a grant from the National Science Foundation. (1961)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 139 (1961), S. 483-497 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091390405
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  • 4
    Electronic Resource
    Electronic Resource
    Surface coats of the mouse blastocyst and uterus during the preimplantation periodSupported by grant 2 R01 HD04962 from the National Institute of Child Health and Human Development. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 180 (1974), S. 31-45 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A glycoprotein coat is demonstrable on the free surface of both the blastocyst and uterine luminal epithelium of the mouse on day 4 and day 5 of normal pregnancy, and on day 7 of delayed implantation, using concanavalin A-peroxidase and ruthenium red. The coats are apparently negatively charged, as shown by their binding with colloidal thorium dioxide. The cell coat on uterine epithelium is appreciably thicker than that on the blastocyst. The information currently available is sufficient to suggest that simplistic mechanisms such as change in charge or total thickness cannot be the sole basis of initial adhesion, but that some localized reduction of the uterine surface coat accompanies adhesion. However, considerably more information is necessary concerning the nature of the surface coats before a more comprehensive understanding of the role of adhesion in implantation can be achieved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091800105
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  • 5
    Electronic Resource
    Electronic Resource
    Protein uptake by rat preimplantation stagesThis study was supported by grant HD 04962 from the National Institute of Child Health and Human Development. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 175 (1973), S. 539-559 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The protein tracers, horseradish peroxidase and ferritin, are demonstrable in the subzonal space of all preimplantation stages within ten minutes when incubated in vivo or in vitro. However, there is very little uptake of these proteins by ova and two-cell stages. By the blastocyst stage there is greatly increased uptake of exogenous protein. The proteins appear in coated micropinocytotic vesicles and tubules, larger vacuoles, and more complex bodies. Blastocysts from the period of lactationally delayed implantation show an even greater amount of uptake, especially in the supranuclear region. Peroxidase reaction product can be demonstrated in the cavity of day 5 blastocysts in 30 minutes, and in the cavity and basal lamina of the blastocysts during delayed implantation in ten minutes. Ferritin was more sparsely distributed, and was not seen in the blastocyst cavity in any of the time periods. Peroxidase is apparently transported via an intracellular pathway, since it is not seen in the elaborate intercellular spaces between trophoblast cells. Acid phosphatase activity is demonstrable in vacuoles, dense bodies and Golgi cisternae in all stages, indicating that the potential for degradation of ooplasm and phagocytized material by a lysosomal system is present in all of the preimplantation stages examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091750304
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  • 6
    Electronic Resource
    Electronic Resource
    A Histological Study of the Cortex of the Ovary of the Adult Armadillo, with Special Reference to the Question of Neoformation of OocytesThis study was supported by a grant by the United States National Science Foundation. (1960)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 136 (1960), S. 491-499 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091360408
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  • 7
    Electronic Resource
    Electronic Resource
    An electron microscope study of the rat endometrium during delayed implantationSupported by National Science Foundation grant G-21829. During the course of this investigation, the senior author was a National Science Foundation Graduate Fellow. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 177-195 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The luminal and glandular epithelia of the rat uterus during delayed implantation have been studied with the electron microscope. The tall columnar cells of the luminal epithelium are characterized by a distinct zonation of organelles. On the free surface there are short microvilli and occasional cytoplasmic extrusions, with terminal bars joining adjacent cells at their apical margins. Beneath the free surface are numerous pinocytotic vesicles and mitochondria. Above the nucleus are a prominent Golgi apparatus with large dilated vacuoles, and numerous dense inclusion bodies. Large clusters of lipid droplets and aggregations of mitochondria occupy the basal zone of the cell.The apical portion of the gland cell has fewer pinocytotic vesicles and the Golgi is smaller than in the luminal epithelial cells. Dense bodies are numerous above the nucleus. The basal portion of the gland cell is devoid of lipid, but there are often one or more enlarged mitochondria. Although a dense PAS+ substance fills the lumina of the glands, there is no obvious evidence of secretory activity in the glands during delay.The relationships of the epithelia to the environment of the blastocysts during delay is discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480208
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  • 8
    Electronic Resource
    Electronic Resource
    Transport and barrier function in the chorioallantoic placenta of the bat, Myotis lucifugusThis study was supported in part by grants 5 R01 HD-02613 from the National Institutes of Child Health and Human Development (A.C.E.) and GB-6435 from the National Science Foundation (W.A.W.). (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 170 (1971), S. 381-399 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The chorioallantoic placenta of the bat (Myotis lucifugus) is hemodichorial and has an ectoplasmic layer and an intrasyncytial lamina interposed between the maternal blood space and the underlying endoplasmic portion of the syncytial trophoblast. The barrier and/or transport function of the trophoblast of this species was investigated. When Thorotrast was injected into the maternal vascular system, only small amounts appeared in the trophoblast, and it could not be demonstrated deep to the syncytial trophoblast.Injected peroxidase and ferritin were both rapidly taken up by the trophoblast, these tracers being found in coated vesicles and tubules, in multivesicular bodies, and in dense bodies. Peroxidase was transported across the trophoblast and could be found in macrophages in the fetal connective tissue and in vesicles in the fetal endothelium. Since ferritin is present in the cytotrophoblast, macrophages and fetal endothelium in uninjected as well as injected animals, the exogenous material could not be followed beyond the syncytium. In addition to demonstrating the cytological pathway by which absorbed proteins cross the trophoblast of the chorioallantoic placenta of the bat, the results of this study suggest that the labyrinth in this species should be considered a possible route for passage of endogenous proteins to the fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091700402
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  • 9
    Electronic Resource
    Electronic Resource
    The composition of the anal glands of Dasypus novemcinctusSupported in part by grant G-9113 from the United States National Science Foundation. (1961)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 108 (1961), S. 295-301 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001080305
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  • 10
    Electronic Resource
    Electronic Resource
    Protein absorption by the guinea pig chorioallantoic placentaThis investigation was supported in part by funds from Public Health Service Predoctoral Fellowship F01-GM42217 and grant 5 R01 HD02613 from the National Institute of Child Health and Human Development. (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 130 (1971), S. 409-429 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Previous experiments have suggested that the guinea pig chorio-allantoic placenta is a barrier to the maternal-fetal passage of proteins. The means by which the placenta exercises this barrier function were investigated by electron microscopy after injection of peroxidase, ferritin, and Thorotrast. Uptake of protein was by coated vesicles which formed at the trophoblast surface, pinched off, and migrated deeper into the cytoplasm. Some vesicles emptied into multivesicular bodies; others migrated across the trophoblast, emptying their content into the underlying compartment. Peroxidase and ferritin were observed in basement membranes within 10-20 minutes after injection. At longer intervals, the proteins were increasingly difficult to demonstrate in basement membranes, although increased amounts were present in the trophoblast. Neither the basement membranes nor the fetal capillary endothelium constituted an effective barrier to proteins which crossed the trophoblast. The results suggest that the trophoblast is the major barrier to maternal-fetal protein transfer across the labyrinth. The trophoblast appears to exercise this barrier function by (a) having a low rate of protein absorption and (b) having multivesicular bodies and lysosomes which sequester and possibly degrade absorbed proteins. However, the trophoblast is not a complete barrier to the passage of these exogenous proteins which may indicate a normal, albeit minor, pathway of maternal-fetal protein transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001300404
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