ISSN:
1432-0533
Keywords:
Early CNS Lesions
;
Experimental Hypercholesterolemia
;
Subdiabetic Rabbits
;
Mitochondrial Alterations
;
Endoplasmic Reticulum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Biochemical and morphologic studies were carried out on the early effect of hypercholesterolemia on the central nervous system in both metabolically normal and subdiabetic rabbits. Major biochemical difference was the elevation of non-esterified cholesterol in the subdiabetic animals. Histologically, Alzheimer type II astrocytosis was noted in the basal ganglia of the subdiabetic rabbits during the 4th week. The astrocytosis extended into the entire protion of the cerebrum and cerebellum during 2 to 4 months. In the metabolically normal rabbits on the cholesterol diet, on the other hand, similar astrocytic changes were noted after 2 months. Despite the fact that cholesterol crystals had frequently been noted in the capillary walls of the viscera after the 2nd week, similar changes were not observed in the blood vessels of the brains of both the subdiabetic and the metabolically normal rabbits during the 4 months of cholesterol feeding. These observations suggest that cholesterol deposits in the vascular walls are determined by the different rates of lipid metabolism in each individual organ.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687550
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