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  • 1970-1974  (12)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 160 (1974), S. 33-45 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ferrets were infected with recombinant influenza A viruses which possessed either the haemagglutinin or neuraminidase antigens of A/Hong Kong/68 influenza virus. After five weeks the immunity of the animals was challenged by infection with A/HK/68 virus. Immunity to challenge infection was greatest in those ferrets with serum HI antibody to A/HK/68; the presence of NI antibody conferred a measurably lower degree of immunity. A small degree of heterotypic immunity was observed following challenge infection of ferrets previously infected with influenza virus A/PR/8/34, although the surface antigens of this virus are completely different from those of A/HK/68. Experiments in which ferrets were infected with A/HK/68 virus and subsequently challenged with the recombinant viruses confirmed the results of the first experiment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 567-569 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The tumours were maintained by serial, subcutaneous inoculation of tumour fragments at 2-3 week intervals. For inoculation of experimental animals, small tumours of 10-15 mm diameter were removed from the animals, freed from normal and necrotic tissue and washed with Hank's saline. They were then ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 75 (1971), S. 2698-2700 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @Cambridge law journal 31 (1972), S. 32-49 
    ISSN: 0008-1973
    Source: Cambridge Journals Digital Archives
    Topics: Law
    Notes: The legal régime of the sea has been a persistently important theme of the law of nations from the beginning; but it has probably never been more dominant than it is at the present time, touching as it does so many of the most vital interests of nations, such as the supply of food and of energy; politically sensitive questions like defence and immigration; and some of the most pressing aspects of pollution and conservation problems. With this renewed importance of the law of the sea have come also new doubts about its content and meaning, and even about the underlying legal principles. Half a century ago, the law of the sea was relatively simple, certain and stable, at any rate in time of peace. The classical dispute between the closed sea and open sea doctrines seemed at last to have been finally resolved on the basis of a kind of dualism by which the coastal state was to have sovereignty over a belt of territorial waters, subject to the general right of innocent passage, and the high seas outside that maritime belt were to be res communis, not subject to acquisition by title of sovereignty, but subject to an international régime which was spelt out in terms of the so-called “freedoms” to be enjoyed by the flags of all nations, the most important being the freedom of navigation and the freedom of fishing.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 45 (1974), S. 99-105 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of ferrets to inoculation with tri-(n-butyl) phosphate split influenza A/Aichi/68 virus vaccine is reported. Normal ferrets did not produce detectable levels of serum HI antibody following inoculation with a single dose of either 640 or 6400 CCA of virus vaccine but produced low titres of antibody following two inoculations of 6400 CCA of virus. This antibody was insufficient to protect the animals against challenge infection with influenza virus A/Hong Kong/68. Ferrets which had been primed by previous infection with heterotypic influenza virus A/PR/8/34, however, responded to immunization with a single dose of 640 CCA of TNBP-split A/Aichi/68 virus by the production of low titres of serum HI antibody. Following immunization these animals were found to be susceptible to challenge infection. The difference in immunogenicity between the TNBP-split vaccine and similar concentrations of whole virus vaccine given to primed ferrets is discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The fat samples analysed averaged 1.1 g wet weight. The procedure of Mills1 was essentially followed for extraction and clean-up, and analysis was completed using a Micro Tek MT-220 and a Varian 2100 gas chromatograph equipped with electron capture detectors, 3H or 63Ni. Columns used: (1) 1.5% ...
    Type of Medium: Electronic Resource
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  • 8
    facet.materialart.
    Unknown
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of philosophical logic. 3:4 (1974:Oct.) 445 
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 42 (1973), S. 197-206 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The serum haemagglutination-inhibiting antibody response of hamsters to immunization with inactivated monovalent influenza vaccines is enhanced if the animals are subjected to a prior infection with a live, heterotypic influenza virus.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 42 (1973), S. 285-296 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ferrets inoculated with 300 CCA of inactivated influenza A2/Hong Kong virus vaccine did not produce serum HI antibody, and were completely susceptible to subsequent infection with live A2/Hong Kong virus. Immunization of ferrets with A2/Hong Kong vaccine in Al(OH)3 induced low levels of serum HI antibody; these animals showed a slightly reduced febrile reaction and reduced titres of virus were recovered from nasal washings following challenge virus infection. Ferrets immunized with inactivated A2/Hong Kong vaccine in Freund's incomplete adjuvant produced relatively high titres of serum HI antibody, but did not produce local antibody detectable in nasal washings. After challenge infection, these animals showed a modified febrile reaction, lower titres of virus were recovered from nasal washings and nasal symptoms were reduced. These results, together with results of similar studies, indicated that the degree of immunity to challenge virus infection was related to the titre of serum HI antibody. However, none of the methods used to induce serum HI antibody gave as solid an immunity as found following live virus infection, although immunization could induce levels of serum HI antibody comparable to that found following virus infection.
    Type of Medium: Electronic Resource
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