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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 11 (1972), S. 1840-1845 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 21 (1970), S. 315-330 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Peripheral blood leucocytes from patients with infectious mononucleosis were cultured and observed during a 24 hour period. In this study are described only the large cells having wide plasma. In the beginning of cultures there are many infectious mononucleosis cells. The nucleus shows a coarse chromatin network. The basophilic plasma has a clear paranuclear zone. Some of them are synthesising DNA. But the most infectious mononucleosis cells transform into cells of the same size with clear plasma. First there are transitional forms, which increase until the 6. hour of culture. Their plasma is weakly basophilic. They transform into clear cells with light plasma often showing red granules. The nucleus shows a rather structureless chromatin. These cells die in the later course of culture. Alle three celltypes described show a strong acid phosphatase activity. The incorporation of3H-Uridine is high in the basophilic cells and decrease as the plasmabasophilia diminishes.
    Notes: Zusammenfassung Die weißen Blutzellen von an infektiöser Mononukleose erkrankten Patienten wurden in 17 Kulturversuchen, von denen 13 quantitativ ausgewertet wurden, über 24 Stunden beobachtet. Ein Stimulans wurde dem Kulturmedium nicht zugefügt. In dieser Arbeit werden die großen Zellen (Durchmesser über 13 μ) mit breitem Plasma beschrieben. Zu Kulturbeginn überwiegen die Drüsenfieberzellen, die durch eine grobe Kernstruktur und ein basophiles Plasma mit paranukleärer Aufhellung gekennzeichnet sind. Ein kleiner Teil von ihnen befindet sich in DNS-Synthese. Die übrigen Drüsenfieberzellen wandeln sich in Zellen gleicher Größe mit hellerem Plasma um. Bereits bis zur 6. Stunde nimmt die Zahl der zunächst entstehenden Übergangsformen, die nur ein leicht basophiles Plasma haben, stark zu. Aus ihnen bilden sich die blassen Zellen, deren Plasma fast keine Basophilie, jedoch häufig Azurgranula zeigt. Ihr Kern ist strukturarm. Sie gehen im weiteren Kulturverlauf zugrunde. Zwischen allen drei Zellformen gibt es fließende morphologische Übergänge, alle zeigen eine deutliche saure Phosphatase-Reaktion. Der Einbau von3H-Uridin ist in den basophilen Zellen am größten und nimmt mit Abnahme der Plasmabasophilie ab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 88-89 
    ISSN: 1432-1440
    Keywords: Lesch-Nyhan Syndrome ; Hypoxanthine-Guanine-Phosphoribosyl transferase enzym protein ; Lesch-Nyhan-Syndrom ; Hypoxanthin-Guanin-Phosphoribosyltransferase ; Enzymprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2 Fällen von Lesch-Nyhan-Syndrom mit vollständigem bzw. teilweisem Fehlen der Hypoxanthin-Guanin-Phosphoribosyltransferase-Aktivität konnte Enzymprotein mit einem gegen normales Erythrocytenenzym gerichteten Anti-Serum nachgewiesen werden. Der Defekt dieser angeborenen Stoffwechselerkrankung scheint demnach in der Synthese eines inaktiven, sich im Doppeldiffusionstest immunologisch normal verhaltenden Enzymproteins zu liegen.
    Notes: Summary In two cases of Lesch-Nyhan syndrome with complete and partial deficiency of hypoxanthine-guanine phosphoribosyl transferase activity, the presence of enzyme protein could be demonstrated using a specific antiserum against hypoxanthine-guanine phosphoribosyl transferase from normal erythrocyte. Therefore, the defect in this disease seems to be based on the synthesis of an inactive but in the double-diffusion-technique immunologically normal enzyme protein.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 1015-1016 
    ISSN: 1432-1440
    Keywords: Enzyme activities (A-PRT) ; (HG-PRT) ; Uricosuric drugs ; Purine biosynthesis ; Gout ; Gichtpatienten ; Uricosuria ; Purinsynthese ; Enzym-Aktivität (A-PRT) und (HG-PRT)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es konnte gezeigt werden, daß Benziodaron neben der bereits bekannten uricosurischen Wirkung auch einen direkten Einfluß auf die Purinsynthese hat. Unter der Therapie von Benziodaron kommt es zu einer Aktivitätssteigerung der Adenin- (A-PRT) und der Hypoxanthin-Guanin-Phosphoribosyltransferase (HG-PRT).
    Notes: Summary Benziodaron, a potent uricosuric drug, also influences the biosynthesis of purines. Following Benziodaron administration the activities of adenine- (A-PRT) and hypoxanthine-guanine-phosphoribosyltransferase (HG-PRT) are increased.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 30 (1974), S. 667-671 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Neutron diffraction experiments have been completed on 243AmO2 and 244Cm2O3. The coherent-scattering amplitude of 243Am, relative to a value of 0.58 × 10-12 for oxygen, is 0.76 (1) × 10-12 cm. The value for curium is ̃0.7 × 10-12 cm, which cannot be determined accurately in this experiment because both C-type (cubic, a = 11.0 Å) and A-type (hexagonal, isostructural with La2O3) Cm2O3 are present in the sample. Some of the difficulties in performing neutron diffraction experiments on these radioactive isotopes, which exhibit self-heating and spontaneous fission, are discussed briefly.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 26 (1970), S. 559-567 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A neutron diffraction study of deuterated potassium ferrocyanide trihydrate (KFCT) has been made above the ferroelectric Curie temperature. The monoclinic form, space group A2/a (No. 15), has a = 9.42, b = 17.01, c = 9.38 Å, and β= 90.03° at 20°C. Since all of the large crystals of KFCT were twinned by a 90° rotation about the b axis, data from both overlapped and nonoverlapped reflections were used in the determination of the structure. Refinement by a modified least-squares method that accounted for the overlapped data led to a weighted R value on F2 (3678 reflections) of 4.8%. The corresponding R on F is 4.9%. The disordered water molecules are of two types: one is disordered into two positions related by a twofold axis parallel to b: the other is disordered into two positions that are related by an approximate 90° rotation in the plane of the molecule. Both types of water molecules show O–D ...O or O–D...N bonding. The Fe(CN)4−6 octahedra are regular and the potassium ions are loosely surrounded by O and N atoms. This analysis has elucidated the role of the water molecules in the ferroelectric switching mechanism. The [{\bar 1}01] ferroelectric axis in this crystal can be explained on the basis of the dipole moment and orientation of the water molecule dipoles.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 6 (1973), S. 206-216 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: X-ray and neutron-diffraction techniques have been used to ascertain the structures of vanadium deuterides with compositions between V2D and V4D3 over a temperature range 5–425 °K. The β phase, V2D, has a monoclinic crystal structure at room temperature with a∼c = 4.46; b = 3.00 Å, β = 95.5°. The deuterium atoms prefer octahedral interstitial sites. Near 425 °K this phase transforms to a b.c.c. phase, and the deuterium atoms prefer tetrahedral sites. The b.c.c. phase of V4D3 has been designated α′ and transforms to α′′ at about 220 °K. This transition is an ordering of deuterium as shown by additional neutron-diffraction peaks. This α′′ structure can be indexed with a∼c∼4.46; b∼3.00 Å; β = 90°. Below 160 °K an additional neutron peak appears at 2&thgr; = 12° which indicates a doubling of the b lattice parameter. This transformation to α′′′ phase involves further ordering. The metal sublattice in α′ and α′′′ is very near b.c.c. Therefore, the neutron patterns do not allow a determination of octahedral or tetrahedral site occupancy. The exact crystal structure cannot be determined. The V–D system is not completely analogous to the V–H system and some of the differences are discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 3 (1970), S. 289-294 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The cryo-orienter is used for neutron diffraction studies of single crystals between liquid helium and room temperatures. It combines a double Dewar cryostat with a three-circle goniostat. The temperature of the crystal is controlled by a combination of exchange gas and a bridge circuit to a stability of ±0.01 Kelvin degree. A ring assembly allows the cryostat to be angularly displaced ±50° from vertical (χ), and to be rotated 360° (φ), which provides crystal motion about two axes with ±0.01° precision. The ring assembly can be rotated about the diffraction vector. Crystals can be mounted along a non-major zone and sufficient data can then be collected with one crystal mounting. The ARCADE computer system controls the entire data collection.
    Type of Medium: Electronic Resource
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