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  • 1
    Electronic Resource
    Electronic Resource
    Polyalkyl aromatic hydrocarbons. II. Cyclialkylation of benzenoid hydrocarbons with isoprene (1968)
    s.l. : American Chemical Society
    The @journal of organic chemistry 33 (1968), S. 2000-2008 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01269a065
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  • 2
    Electronic Resource
    Electronic Resource
    An In Vitro Model for the Expansion of Vγ9δ2 T Lymphocytes During Development (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 40 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The 7/γ/δTlymphocytes represent a minority of T lymphocytes in human peripheral blood. Although there have been reports of reactivity against (myco-) bacterial antigens and heat shock proteins, their function and antigen specificity remain ill defined. The biological role of γ/δ T cells has been related to functions within the ‘first line of defense’. Similar to γ/δ T lymphocytes in the T-cell compartment, CD5 positive B cells represent a small subset of B lymphocytes, which is thought to be involved in the maintenance of natural immunity and autoimmunity. We provide evidence for the cooperation of γ/δ T cells and CD5 positive B cells in the proliferative response of γ/δ T cells to bacterial antigens. Our data indicate a strong proliferation of Vγ9δ2 T cells in response to gram-negative bacteria, which is dependent upon the presence of CD5 positive B-CLL or activated normal B lymphocytes. The selective stimulation of the Vγ9δ2 subpopulation by gram-negative bacteria is also confirmed by analysis of different γ/δ T-cell clones. The interaction of γ/δ T cells with activated B cells and gram-negative bacteria may prove to be a useful model similar to the expansion of the Vγ9δ2 subpopulation during development. In addition, our in vitro system should provide new insights in the interaction of CLL B cells with the immune system and the antigens recognized by γ/δ T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03499.x
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  • 3
    Electronic Resource
    Electronic Resource
    NITROHETEROCYCLES WITH ANTIPARASITIC EFFECTS (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 160 (1969), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1969.tb15872.x
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  • 4
    Electronic Resource
    Electronic Resource
    Das kombinierte intravenöse Uro-Cholecyst-Cholangiogramm (1968)
    Springer
    Langenbeck's archives of surgery 322 (1968), S. 758-761 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Mittels dieser kombinierten Untersuchungsmethode sind Nieren, Ureteren, Gallenblase und große Gallengänge in einer über 2 h.p.i. laufenden Aufnahmeserie nach gemeinsamer Gabe von Nieren- und Gallenkontrastmittel diagnostisch erfaßbar. Die Verträglichkeit ist einwandfrei, die Aufnahme-Detail-beurteilbarkeit zwischen 75–90% je nach Organ und Erkrankung sehr gut. Die diagnostische Ergiebigkeit zeigt die Feststellung von 45 pathologische Befunden bei 90 Untersuchten. Die Methode vermindert Zeit-, Materialaufwand und Strahlenbelastung bei schneller und guter Information.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453923
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  • 5
    Electronic Resource
    Electronic Resource
    Single-dose toxicokinetics of aluminum in the rat (1992)
    Springer
    Archives of toxicology 66 (1992), S. 700-705 
    Details
    ISSN: 1432-0738
    Keywords: Aluminum ; Toxicokinetics ; Rat ; Parenterals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The toxicokinetics of aluminum (Al) in male Wistar rats was studied after single intragastric (IG) doses of 1000 and 12000 μg Al/kg and intravenous (IV) doses of 10, 100, 1000, and 12000 μg Al/kg. Serial blood samples, daily samples of urine and feces as well as brain, liver, kidney, spleen, quadriceps muscle, and femur samples were collected. Al was measured by atomic absorption spectrometry. Al blood profiles after IV doses were adequately described by a two-compartment open model. Al toxicokinetics was dose dependent and appeared to plateau at 12000 μg/kg. At IV doses between 10 and 1000 μg/kg the terminal half-life of elimination from whole blood (t1/2β) increased from 29.9±7.8 to 209.3±32.6 min, and the total body clearance (CL) decreased from 2.45±0.64 to 0.28±0.03 ml min−1 kg−1. Following an IV bolus of 10 and 100 μg/kg the administered Al was recovered completely from urine (94.4%±9.9% and 98.5%±3.2%). Twenty-nine days after the IV dose of 1000 μg/kg daily renal excretion decreased to baseline values while only 55.1%±8.0% of the dose was excreted. Nineteen days after the single IV dose of 1000 μg/kg Al accumulated in liver (28.1±7.7 versus 1.7±0.5 μg/g of control rats) and spleen (72.5±21.1 versus 〈0.4 μg/g). After the single 1000 μg/kg IG dose no absorption of Al was detectable. The IG dose of 12000 μg/kg resulted in a maximum blood Al level of 47.9±12.4 μg/l after 50 min. The blood concentration time curve fitted a one-compartment open model with a half-life of absorption of 28.2±3.6 min and a t1/2β of 81.2±20.2 min. Cumulative renal Al excretion was 0.18%±0.10% of the dose and oral bioavailability was 0.02%. Seventeen days after the 12000 μg/kg IG dose the Al content in femur samples was increased (2.7±1.3 versus 0.6±0.4 μg/g). In no case was fecal elimination of incorporated Al observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972620
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  • 6
    Electronic Resource
    Electronic Resource
    Ein chemisch neuartiger Vasodilatator mit Wirkung auf die Lungenstrombahn (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 208-209 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 4-[5-Amino-3-(4-pyridyl)-1 pyrazolyl]-1-methyl-piperidine (CIBA 31531-Ba) was found to have a relatively pronounced vasodilator effect on the pulmonary circulation in the open chest, right heart-bypass cat with fixed cardiac output. This compound most probably has a direct effect on the vascular smooth muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900909
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  • 7
    Electronic Resource
    Electronic Resource
    o-Allyloxy-phenoxy-propanolamine, eine neue Gruppe adrenergischer β-Rezeptoren-Blocker (1967)
    Springer
    Cellular and molecular life sciences 23 (1967), S. 651-652 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The synthesis of a new class of adrenergicβ-receptor blocking agents based upon ao-allyloxy-phenoxy-propanolamine structure is described. The structure activity relationships were studied, and the structural elements responsible for an optimal pharmacological effect are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02144181
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  • 8
    Electronic Resource
    Electronic Resource
    Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 728-734 
    Details
    ISSN: 1432-1440
    Keywords: Amalgam ; Lymphocytes ; Immune system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dental amalgam has been considered to have adverse side effects on the immune system. Reports have been contradictory, indicating both an increase and a decrease in peripheral blood lymphocyte counts associated with amalgam restorations. We investigated two groups of patients, one of which was treated with amalgam restorations for the first time. In the other group, all existing amalgam fillings were removed. Prior to and after treatment, we determined the absolute and relative numbers of granulocytes, lymphocytes, monocytes, T cells, B cells, cytotoxic T cells, helper T cells and natural killer cells. In addition, functional investigations of T cells were performed. We failed to find any effect of amalgam restorations on the immune system in terms of the parameters investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180738
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  • 9
    Electronic Resource
    Electronic Resource
    Neuron-specific enolase-like immunoreactivity in the vertebrate retina: selective labelling of Müller cells in Anura (1992)
    Springer
    Histochemistry and cell biology 98 (1992), S. 243-252 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Neuron-specific enolase (NSE) immunocytochemistry was carried out in retinae of goldfish, axolotl, clawed frog, cane toad, lizard, chick, guinea-pig, rabbit, rat, cat and human. With the exception of Anura, strong immunoreactivity was seen in the large ganglion, amacrine cells and horizontal cells of the retina in all of the other species. Photoreceptors were found to be labelled in the rat and human retina and only one cone type in rabbit. Photoreceptor pedicles and ellipsoids were stained in the goldfish and the somata and inner segments of some photoreceptors in axolotl. In the axolotl retina, besides neurons, Müller cells (MCs) were also immunolabelled. In the retina of the cane toad and the clawed frog MCs were the only stained elements. Similarly in other parts of the central nervous system of the cane toad, glial elements of the optic tectum and spinal cord were immunoreactive. In contrast, in the peripheral nervous system, neurons of the 1st sympathetic ganglion and the 2nd dorsal root ganglion were labelled. In double-labelling experiments, glial fibrillary acidic protein and NSE showed colocalisation both in the glial elements of the optic tectum and spinal cord and in MCs of the retina of the cane toad.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271038
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  • 10
    Electronic Resource
    Electronic Resource
    Zur Methylierung von 1-Phenyl-5-sulfanilamido-pyrazol (1965)
    Springer
    Naturwissenschaften 52 (1965), S. 106-107 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626320
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