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  • 1
    Electronic Resource
    Electronic Resource
    Treatment with GM1 Ganglioside Restores Striatal Dopamine in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 51 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 30 mg/kg i.p. daily for 7 days, was administered to mice. This dosage regimen resulted in an ∼50% reduction of striatal dopamine (DA) level. Chronic administration of GM1 ganglioside (II3NeuAc-GgOse Cer), beginning between 1 to 4 days after terminating MPTP dosing, resulted in partial restoration of the striatal DA level. From dose- and time-response studies, it appeared that 30 mg/kg i.p. of GM1 administered daily for ∼23 days resulted in an ∼80% restoration of the DA level and complete restoration of the 3,4-dihydroxyphenylacetic acid (DOPAC) content. This dosage of GM1 also restored the turnover rate of DA in the striatum to near normal. Discontinuing GM1 treatment resulted in a fall of DA and DOPAC levels to values found in mice treated with MPTP alone. There was no evidence for regeneration of nerve terminal amine reuptake in the GM1-treated mice as evaluated by DA uptake into synaptosomes. Our biochemical findings in animals suggest that early GM1 ganglioside treatment of individuals with degenerative diseases of dopaminergic nigrostriatal neurons might be fruitful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb03086.x
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  • 2
    Electronic Resource
    Electronic Resource
    N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Increases Acetylcholine and Decreases Dopamine in Mouse Striatum: Both Responses Are Blocked by Anticholinergic Drugs (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuropathology and clinical symptoms that resemble Parkinsonism in primates and humans. In mice it induces a long-lasting depletion of neostriatal 3,4-dihydroxyphenylethylamine (dopamine) content. Using the mouse, we found that MPTP induces a fall of dopamine and a rise of acetylcholine in the neostriatum. Both responses to MPTP can be blocked by prior treatment with atropine or trihexyphenidyl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb10558.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 1140-1141 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto Scimmie scoiattolo trattate cronicamente con MnO2 presentano disturbi del sistema extrapiramidale ed una riduzione delle concentrazioni di serotonina e dopamina nel nucleo caudato. L'intensità dei disturbi extrapiramidali e la riduzione della concentrazione delle amine nel caudato appaiono correlate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900234
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  • 4
    Electronic Resource
    Electronic Resource
    Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease (1989)
    Springer
    Experimental brain research 77 (1989), S. 329-336 
    Details
    ISSN: 1432-1106
    Keywords: Neural transplantation ; Xenograft ; Fetal pig ; Rat striatum ; Rotational behavior ; Tyrosine hydroxylase immunohistochemistry ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A suspension of cells from embryonic day 21 fetal pig ventral mesencephalon was transplanted into the striatum of 20 immunosuppressed rats with 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Of these rats, 15 showed reduction of amphetamine-induced ipsilateral rotation by 9 weeks and complete reversal of rotation by 14–17 weeks. Animals maintained stable reversal of rotations (contralateral direction) until cessation of Cyclosporin A (CyA) treatment at 15–20 weeks. Within 4–9 weeks after CyA removal, these rats showed exclusively ipsilateral rotations during behavioral testing which were comparable to pre-transplant levels, suggesting that the grafts were rejected upon cessation of CyA treatment. Rats were sacrificed and tyrosine hydroxylase (TH) immunohistochemistry was performed at several time points, both on and off CyA, to examine a possible correlation between the degree of rotational behavior and the number of TH- positive surviving grafted cells. Staining showed large numbers (230–12,329) of TH-positive surviving cells in animals displaying a high degree of rotational correction (1.6 to -9.6 net ipsilateral rotations/min) after cessation of CyA treatment. Two control groups, those transplanted with nonneuronal cells from the pig ventral mesencephalon (n=5) and those receiving only daily CyA injections (n=4) showed no significant reduction of net ipsilateral rotations throughout the experiment. No TH-positive surviving cells were seen in the one non-neuronal transplant analyzed. This data demonstrates long-term retention of xenografted tissue with immunosuppression and its concomitant restoration of normal motor behavior in the rat model of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274990
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of lithium chloride administration on brain and heart norepinephrine turnover rates (1969)
    Springer
    Psychopharmacology 14 (1969), S. 315-322 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Norepinephrine ; Kinetics ; Brain Chemistry ; Manic-Depressive Psychoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of Li+ on NE turnover rates in rat heart and brain was studied. Turnover rates were determined in brain and heart by blocking tyrosine hydroxylase with L-α-methyltyrosine and following the decline of NE with time or in heart by injecting3H-NE and following the decline of NE specific activity with time. Subacute treatment with LiCl in doses that maintained a serum lithium level within the clinically therapeutic range caused: 1. A 95% increase in brain NE turnover rate without altering the steady-state level of the amine. 2. A slight but not significant increase in heart NE turnover. 3. The selective increase in brain NE turnover, compared to heart, may be attributed to the higher tissue levels of Li+ found in the brain under the conditions of study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190116
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    Paper (German National Licenses)
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