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  • 1
    Electronic Resource
    Electronic Resource
    CYCLIC 3′5′-ADENOSINE MONOPHOSPHATE AND CENTRAL CIRCULATORY CONTROL IN CATS AND DOGS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Dibutyryl cyclic AMP (Db CAMP, 75–500 μg/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate.2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure.3. A number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new β2-adrenoceptor stimulant, NAB 365.4. Injection into the lateral ventricle of theophylline or Ro 7/ 2956, both inhibitors of phosphodiesterase, similarly increased blood pressure.5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H1- or H2-receptors.6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective.7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02671.x
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  • 2
    Electronic Resource
    Electronic Resource
    An experimental study of the antineutron-light nucleus annihilation at 1.4 GeV/c (1979)
    Springer
    The European physical journal 292 (1979), S. 197-203 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The heavy liquid bubble chamber, Gargamelle, has been used to investigate the gross features of the annihilation of antineutrons in light nuclei (mainly Carbon). Results are presented on the distributions of multiplicity, momentum and emission angle for charged pions and protons together with a simple model to describe them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441626
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  • 3
    Electronic Resource
    Electronic Resource
    Dasβ-Spektrum des Cs137 (1962)
    Springer
    The European physical journal 168 (1962), S. 292-297 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Theβ-ray spectrum of Cs137 has been measured with an iron-free spectrometer. The energy of the soft component was found to beE 0=514±2 keV. The parameterk of the hard-component shape factorC 2VA (2) (W)=q 2+kp 2 was determined to bek=0.015±0.004. Theβ intensities amount to 6.5% (hard component) and 93.5% (soft component). TheK conversion coefficient of the isomeric transition was measured to beα K=0.093±0.003, in excellent agreement withSliv's theoretical value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01384321
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  • 4
    Electronic Resource
    Electronic Resource
    Messung von fünf β-γ-Zirkularpolarisationskorrelationen beim Zerfall Eu152→Gd152 (1964)
    Springer
    The European physical journal 179 (1964), S. 528-531 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In the decay Eu152→Gd152 fiveβ(circularly polarizedγ) correlations have been measured (Table). The Fermi matrix element of the 3−–3− β transition is small or vanishing. The levels of 344 and 755 keV (I=2+ and 4+, respectively) seem to be collective states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01380825
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  • 5
    Electronic Resource
    Electronic Resource
    Modifications de l'excitabilité des centres vasopresseurs hypothalamiques par des injections locales de catécholamines (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 565-566 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The blood pressure is not disturbed by a local injection of norepinephrine into the hypothalamus, but the excitability of vasopressor centres is affected. Often, the excitability of these centres is decreased; sometimes, it is increased, and, more rarely, it is first potentiated and then inhibited. Epinephrine has the same action, but dopamine is less potent; isoprenaline produces both facilitation and inhibition of these centres, but the facilitating effect is more frequent than with norepinephrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02172183
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  • 6
    Electronic Resource
    Electronic Resource
    Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 255-261 
    Details
    ISSN: 1432-1912
    Keywords: Baroreceptor reflex arc ; Carotid sinus nerve ; Centrally mediated vagal bradycardia ; Fentanyl ; Nucleus of the solitary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In dogs, anaesthetized with chloralose, fentanyl (5 μg/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not change the bradycardic response to stimulation of the nucleus of the solitary tract (NTS) indicating that a central facilitation of baroreceptor impulses occurs within the NTS, probably at the first synapse of baroreceptor reflex fibres. Bilateral destruction of the NTS caused a ful-minating hypertension and tachycardia similar to that after cutting the baroreceptor afferent fibres. After both procedures, fentanyl (20 μg/kg i.v.) produced marked hypotension and bradycardia. The bradycardic effect was abolished by cutting both vagal nerves when the dogs were pretreated with a β-adrenoceptor blocking agent (S 2395, 50 μg/kg i.v.). The results provide evidence that the NTS is not the main site of action either for the hypotensive effect or for the vagally mediated bradycardia of fentanyl. Since the dorsal nucleus of the vagal nerve was destroyed together with the NTS, this nucleus does also not appear to be a major site of the action of fentanyl. Blockade of dopamine receptors by haloperidol or pimozide or of serotonin receptors by methysergide did not change the hypotensive, bradycardic and sympathoinhibitory effects of fentanyl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498691
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  • 7
    Electronic Resource
    Electronic Resource
    Gibt es eine medikamentöse Beeinflussung der Frakturheilung? (1960)
    Springer
    Archives of orthopaedic and trauma surgery 52 (1960), S. 5-13 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Art und Wirkungsweise von Medikamenten, die die Knochenbruchheilung beschleunigen sollen, werden besprochen. Dann wurden einige dieser Präparate im klinischen Versuch kontrolliert. Weder Vitamine, Hormone, Organpräparate, Trockenzellen, Bogomoletzserum und hyperämisierende Medikamente konnten nach unseren Ergebnissen eine wesentliche Verkürzung der Knochenbruchheilung bewirken, so daß nach wie vor für die Behandlung der Fraktur in erster Linie die klassischen Gesichtspunkte der Reposition und Fixierung gelten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415577
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative analysis of the size distribution of target-and targetoid fibres employing the method of daeves and beckel for mixed distributions (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 215-220 
    Details
    ISSN: 1432-0533
    Keywords: Skeletal muscle ; Denervation atrophy ; Target fibres ; Analysis of size distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of frequency distribution is performed in 250 target and targetoid fibres each from the anterior tibial muscle of a case with rapidly proceeding denervation atrophy. Following plane measurements on cross sections the size data were analysed according to the method of Daeves and Beckel [1] for mixed distributions. Three homogeneous normally distributed populations could thus be extracted from the mixed distributed sample. The largest population represents target fibres with a normal size range, while the second one encloses hypertrophic fibres, and the third and smallest one consists of fibres ranging within atrophic size limits. These findings support the previous presumption that targets predominantly occur in fibres of normal size and can therefore be regarded as manifestations of an early stage of denervation atrophy. The targetoid fibres, on the contrary, are of an atrophic size by 84%, while only a small population of about 15% contains targetoid fibres of a normal size on cross section.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702673
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  • 9
    Electronic Resource
    Electronic Resource
    Partial transtentorial displacement of the cerebellum and the brain stem in hydrocephalus — A primary condition or a result of treatment? (1976)
    Springer
    Acta neurochirurgica 33 (1976), S. 151-165 
    Details
    ISSN: 0942-0940
    Keywords: brain stem, cerebellum ; transtentorial displacement ; hydro-cephalus communicans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two oases of upward displacement of parts of the brain stem and the cerebellum are discussed. In both cases shunts for a hydrocephalus had been operating for a long time (three and a half years in one and seven months in the other). One infant had a meningomyelocele but no complete Arnold-Chiari malformation. The cause of the hydrocephalus in the other case was doubtful, but was thought to be transtentorial displacement of the brain stem and the cerebellum causing traction on the pons and consequent meningeal fibrosis with obstruction of the cisterna pontis. In this case osseous hypoplasia of the posterior fossa was excluded by craniometry, so the upward displacement must have been due to hypoplasia of the tentorium cerebelli and its low attachment to the occiput, bringing about a narrowing of the infratentorial space. The authors believe the condition to be a primary malformation, and reject the hypothesis of secondary herniation following long standing supratentorial decompression. The concept of a primary malformation is supported by previous descriptions of the condition in cases with spina bifida, Arnold-Chiari malformation, and hydrocephalus without shunting, as well as by other features in the cases which have been recorded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886666
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  • 10
    Electronic Resource
    Electronic Resource
    The influence of chronic deep brain stimulation on excitability and morphology of the stimulated tissue (1979)
    Springer
    Acta neurochirurgica 47 (1979), S. 123-129 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bipolar electrical stimulations of the rostral hippocampus and of the amygdala were performed at irregular intervals in wakeful unrestrained cats via chronically implanted glass-insulated stainless steel electrodes. The excitability of the stimulated tissue remained unchanged during the whole investigation period of six months up to one and a half years, as was revealed by regularly performed comparisons of shape, latency, and amplitude of evoked potentials elicited by electrical stimulation of the rostral hippocampus and recorded within the ipsilateral mammillary body. The histological examination of the stimulated tissue revealed a fibrillary gliosis due to the trauma caused by the insertion of the electrodes, but no signs of additional tissue damage due to electrical stimulation or chronic mechanical irritation. The results indicate that it is possible to perform therapeutic stimulations of deep brain structures for long periods without inducing relevant changes in morphology or electrical responsiveness of the stimulated tissue. No kindling phenomena are to be expected, if the stimulations are performed at irregular intervals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404668
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