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  • 1985-1989  (3)
  • 1945-1949  (2)
  • 1
    ISSN: 1432-1041
    Keywords: somatostatin analogue ; oral formulation ; gastrointestinal absorption ; SMS 201-995 ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To determine the local gastrointestinal absorption of a new synthetic somatostatin analogue (SMS 201-995 = Sandostatin), an intestinal tube was passed in eight healthy volunteers and on different days an aqueous solution was administered at four different locations: stomach, proximal duodenum, ligament of Treitz and jejunum. In a follow-up study, an oro-ileal tube was passed in six of the original volunteers and the drug solution was administered in to the terminal ileum. The aqueous solution of SMS was rapidly absorbed from the gastrointestinal tract after local application, and it was well tolerated. Absorption of the drug from the different sites was comparable, although there was a tendency to decreased peptide absorption after ileal administration. Absorption of the drug was quite variable between the subjects and the different locations. The dose-corrected systemic availability relative to subcutaneous administration in another study was 0.28%. However, significant plasma SMS concentrations were achieved, suggesting that oral delivery of the polypeptide may eventually be possible for long-term treatment of a variety of disorders.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 57 (1989), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Cells of Bacillus subtilis 168+ were labeled with 32P-orthophosphate during the process of sporulation, germination and outgrowth. By two-dimensional gel electrophoresis, at least 30 protein species were found to be radioactively labeled; 30% of these were modified by phosphorylation. Significant changes in the protein phosphorylation pattern during growth and cellular differentiation could be demonstrated. Using γ-32P-ATP evidence for an ATP-dependent protein kinase was also obtained. Under these conditions 4 proteins with a molecular mass of 109 600; 103 100; 73 300 and 32 200 Da were found to be phosphorylated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 3 (1947), S. 327-335 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 321 (1985), S. 65-67 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Experiments on quantitative elemental analysis of glasses with muonic X-rays have been performed. The summed-up Lyman intensities were compared with the known abundances of the samples in order to deduce calibration numbers per element. In favourable cases a precision of the order of 1% of the respective abundance was obtained. The level of detection was about 100 ppm. The method is completely non-destructive and allows selection of certain parts (scanning), even well inside the sample. It may be combined with truly three-dimensional visualization.
    Notes: Zusammenfassung Es wurden Experimente zur quantitativen Elementanalyse von Gläsern mit myonischer Röntgenstrahlung durchgeführt. Die Summe der Intensitäten in der myonischen Lymanserie wurde für die verschiedenen Elemente der Proben mit den bekannten atomaren Konzentrationen verglichen und damit für jedes Element eine Eichzahl erhalten. In günstigen Fällen konnte die Konzentration mit einer Genauigkeit von etwa 1% bestimmt werden. Die Nachweisgrenze lag bei 100 ppm. Die Methode ist völlig zerstörungsfrei. Es können auch ausgewählte Teile einer Probe analysiert werden (‘scanning’), selbst wenn sie weit innerhalb liegen. Die Methode kann mit einer dreidimensionalen Darstellung der Zusammensetzung verbunden werden.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 128 (1948), S. 522-533 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Zusammenfassung Je eine Probe Isobutylphenol. Chlorisobutylphenol und Divinylbenzol wurde raman-spektralanalytisch untersucht unter Zuhilfenahme von Erwartungsspektren. Diese selbst konnten auf Grund bekannter Gesetzmäßigkeiten von Aromatenspektren abgeleitet werden.
    Type of Medium: Electronic Resource
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