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A biologically active diphenyl ether from the green algaCladophora fascicularis (1985)

Kuniyoshi, M. ; Yamada, K. ; Higa, T.

Springer

Cellular and molecular life sciences 41 (1985), S. 523-524

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ISSN: 1420-9071

Keywords: Green alga ; alga ; green ; Cladophora fascicularis ; diphenyl ether ; polybrominated ; 2-(2′,4′-dibromophenoxy)-4,6-dibromoanisole

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary A new polybrominated diphenyl ether (1) has been isolated from the green algaCladaphora fascicularis, and the structure was determined by spectral analysis and conversion to known compounds. It showed antibacterial and antiinflammatory activities.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01966182

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Evaluation of mixed chimerism by two-step polymerase chain reaction amplification of hypervariable region MCT118 after allogeneic bone marrow transplantation (1994)

Tanaka, J. ; Kasai, M. ; Imamura, M. ; [et al.]

Springer

Annals of hematology 68 (1994), S. 189-193

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ISSN: 1432-0584

Keywords: Bone marrow transplantation Chimerism ; Graft failure ; Polymerase chain reaction ; Variable number of tandem repeat regions

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary We assessed the origin of peripheral blood cells and bone marrow cells of 92 samples obtained from 19 patients after allo BMT by two-step polymerase chain reaction (PCR) amplification of MCT118, one of the variable number of tandem repeat regions (VNTR) which has a different length in 19 of 32 sibling pairs examined, that can detect the DNA pattern of a minor cell population of only 1% without using radioisotopes. Mixed chimerism (MC) was detected in the hematopoietic cells of four patients. Two patients who showed progressive MC developed relapse of leukemia 3 months and 4 months after the detection of MC, and two patients died with bone marrow hypoplasia 61 days and 7 months after BMT. These data suggest the clinical importance of analyzing the correlation of MC and clinical complications after BMT by this method, which can be used to monitor MC in about two thirds of allo BMT patients with an adequate sensitivity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01834365

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Successful second allogeneic bone marrow transplantation in a relapsed acute myeloid leukemia patient with fungal liver abscess (1992)

Tanaka, J. ; Kasai, M. ; Masauzi, N. ; [et al.]

Springer

Annals of hematology 65 (1992), S. 193-195

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ISSN: 1432-0584

Keywords: Bone marrow transplantation ; Fungal infection ; rhG-CSF

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Disseminated fungal infection not infrequently complicates the course of allogeneic bone marrow transplantation (allo BMT) in severely immunocompromised patients, and the prognosis of BMT patients who develop systemic fungal infection is very poor. We describe a patient who developed disseminatedCandida albicans infection with liver abscess after the first allo BMT for acute myelogenous leukemia (FAB M2). The infection was successfully eradicated by the administration of miconazole and amphotericin B. However, 1 year after the first allo BMT, the patient suffered a relapse of acute myelogenous leukemia with fungal liver abscess. A second allo BMT, accelerating granulocyte recovery by recombinant human granulocyte colony-stimulating factor (rhG-CSF), was successfully performed and the fungal liver abscess resolved with a combination therapy of fluconazole and amphotericin B. The patient is alive and free of both leukemia and fungal disease more than 37 months after the first allo BMT and 25 months after the second allo BMT.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01703114

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