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  • 1
    Electronic Resource
    Electronic Resource
    25 Hydroxyvitamin D and vitamin E absorption in healthy children and children with chronic intrahepatic cholestasis (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 605-609 
    Details
    ISSN: 1432-1076
    Keywords: 25-Hydroxyvitamin D ; 1,25-Dihydroxyvitamin D ; Vitamin E-Vitamin D binding protein ; Chronic cholestasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with chronic cholestasis have reduced 25-hydroxyvitamin D (25 OHD) and vitamin E levels. We determined serum concentrations of 25 OHD, 1,25-dihydroxyvitamin D [1,25(OH)2D] and vitamin E before and after oral administration of 10 μg/kg body weight 25-hydroxyvitamin D3 (25 OHD3) and 100 IU/kg body weight vitamin E, respectively, in 4 patients with intrahepatic cholestasis and 6 healthy children. Vitamin E increased in all controls but in only one of the four patients. In contrast, oral 25 OHD3 induced a normal rise in circulating 25 OHD and 1,25(OH)2D. The low serum levels of 25 OHD in the patients before the oral bolus may have been due to inadequate parenteral vitamin D administration and/or to the simultaneous phenobarbital treatment. The latter possibility is supported by the increase of serum 25 OHD into the normal range after withdrawal of phenobarbital in one of the four patients. We conclude that vitamin E has to be supplemented parenterally or in water-soluble oral form. Further studies are necessary to clarify whether high-dose long-term oral 25 OHD3 supplementation is sufficient to prevent vitamin D deficiency in patients with chronic cholestasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441510
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  • 2
    Electronic Resource
    Electronic Resource
    Trennung der intestinalen β-Galactosidasen beim lactose-toleranten Erwachsenen durch Ultrazentrifugation im Dichtegradienten (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 258-259 
    Details
    ISSN: 1432-1440
    Keywords: Lactose tolerance ; intestinalβ-Galactosidases ; ultracentrifugation ; Lactose-Toleranz ; intestinaleβ-Galactosidasen ; Ultrazentrifugation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die intestinalenβ-Galactosidasen von 4 lactose-toleranten, erwachsenen Mitteleuropäern wurden im Saugbiopsie-Gewebe nach Solubilisierung mit Triton X-100 in einem linearen Mannitol-Gradienten (5–20%) auf der Ultrazentrifuge bei 4°C und 44000 U/min getrennt. Bei 12stündiger Zentrifugation fanden sich 3 Fraktionen, von denen die beiden schneller sedimenticrenden Lactose spalten. Alle 3 Fraktionen hydrolysieren p-Nitrophenyl-β-Galactosid. Die 3 isoliertenβ-Galactosidasen entsprechen wahrscheinlich der „neutralen“ Bürstensaum-Lactase, der „sauren“ lysosomalen Lactase und einer cytoplasmatischen Hetero-β-Galactosidase.
    Notes: Summary The intestinalβ-galactosidases in suction biopsy material of 4 lactose-tolerant adult Europeans were separated after solubilization with Triton X-100 in a linear 5–20% mannitol gradient by ultracentrifugation at 4°C and 44000 rpm. After a centrifugation time of 12 h 3 fractions were identified. The 2 fractions which sedimented more rapidly were active with lactose as substrate; all 3 fractions hydrolized p-nitrophenyl-β-galactoside. The 3 isolatedβ-galactosidases probably correspond to the “neutral” brush border lactase, the “acid” lysosomal lactase, and a cytoplasmatic hetero-β-galactosidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486532
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Trennung der intestinalen β-Galactosidasen beim lactose-intoleranten Erwachsenen durch Ultrazentrifugation im Dichtegradienten (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 260-261 
    Details
    ISSN: 1432-1440
    Keywords: Lactose intolerance ; intestinalβ-Galactosidases ; ultracentrifugation ; Lactose-Intoleranz ; intestinaleβ-Galactosidasen ; Ultrazentrifugation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 11 erwachsenen Versuchspersonen mit Lactose-Intoleranz konnten bei der Trennung der intestinalenβ-Galactosidasen im Dichtegradienten die „neutrale“ Bürstensaum-Lactase und die „saure“ lysosomale Lactase nachgewiesen werden. Im Vergleich zu lactose-toleranten Erwachsenen war die Bürstensaum-Lactase stark vermindert. Die Hetero-β-Galactosidase, die bei lactose-toleranten Erwachsenen als langsam sedimentierendes Enzym nachweisbar ist, fehlte bei allen 11 Versuchspersonen.
    Notes: Summary In 11 adult probands with lactose intolerance the intestinalβ-galactosidases were separated in a density gradient by ultracentrifugation. The “neutral” brush border lactase and the “acid” lysosomal lactase were identified in the biopsy material of all 11 subjects. In comparison with lactosetolerant adults the brush border lactase was markedly diminished. The hetero-β-galactosidase which is present as a slowly sedimenting enzyme in lactose-tolerant adults, was absent in all of the 11 subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486533
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    Paper (German National Licenses)
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