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  • Chemistry  (3)
  • Histamin  (2)
  • Methadone  (2)
  • 27.70.+ q  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Synergistic effects of adrenaline and mepyramine on the anaphylactic reactions of the bronchi and pulmonary vessels in the guinea pig heart-lung-preparation (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 224-240 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Anaphylaxis ; Histamine ; Antihistaminics ; Cateoholamines ; Pulmonary Circulation ; Bronchospasm ; Anaphylaxie ; Histamin ; Antihistaminica ; Katecholamine ; Lungenkreislauf ; Bronchospasmus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. In the guinea pig heart-lung-preparation (HLP) anaphylactic bronchospasm was not greatly affected by mepyramine (2–40 μg/ml blood), adrenaline (0.1 and 1 μg/ml), noradrenaline (0.1 μg/ml) or papaverine (100 μg/ml) but was completely abolished by combining mepyramine with the lower dose of adrenaline. A partial antagonism was achieved by the combined action of mepyramine and papaverine which became complete when adrenaline was added. 2. Bronchospasm due to histamine was completely prevented by mepyramine, but only partially antagonized by both adrenaline doses used. 3. The increase of pulmonary vascular resistance in anaphylaxis was not inhibited by the highest tolerated amounts of mepyramine or papaverine, no matter whether the drugs were given alone or in combination. Adrenaline, in contrast to noradrenaline, was partially effective at the lower dose (0.1 μg/ml). The higher concentration did not act more strongly. It became fully effective when mepyramine was added either alone or combined with papaverine. 4. The increase of pulmonary vascular resistance induced by histamine was strongly and significantly antagonized by mepyramine alone as well as by the lower concentration of adrenaline (0.1 μg/ml). Noradrenaline had no significant effect in either amount given (0.1 and 1 μg/ml). 5. Antigen increased heart rate in sensitized HLPs, probably due to histamine release. This effect was resistant to mepyramine. 6. The present findings are discussed a) with respect to the refractoriness of the anaphylactic bronchospasm to mepyramine, an effect displayed in isolated lung preparations but not in intact animals. b) with respect to the mechanism of the so-called protracted shock which is mainly due to heart failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00997094
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  • 2
    Digitale Medien
    Digitale Medien
    Sustained ingestion of methadone and the sleep of monkeys (1978)
    Springer
    Psychopharmacology 60 (1978), S. 29-34 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Sleep ; Methadone ; Sustained ingestion ; Monkey
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Methadone HCl was administered daily to four stump-tailed macaques. The animals' sleep was periodically examined throughout a year of methadone maintenance and, in two animals, during eight months of withdrawal. REM sleep was substantially decreased by methadone treatment and gradually returned to predrug values over a 6-to 8-month period of maintenance. Measures of non-REM sleep and awakenings showed similar disruption with no return to predrug values. These changes were not correlated with alterations in plasma-methadone concentrations. REM sleep rebound occurred temporarily upon drug with-drawal in two animals, but no consistent sleep disruption was apparent during the subsequent eight months. Contrary to some suggestions, therefore, tolerance to the sleep-disruptive effects of the drug may be specific and incomplete, and extended REM rebound upon withdrawal is not a universal response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429175
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  • 3
    Digitale Medien
    Digitale Medien
    The role of histamine and catecholamines in anaphylatoxin shock as compared to the anaphylactic shock (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 266 (1970), S. 208-222 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Anaphylatoxin ; Anaphylaxis ; Histamine ; Catecholamines ; β-Adrenergic Blockade ; Anaphylatoxin ; Anaphylaxie ; Histamin ; Katechol amine ; β-adrenergische Blockade
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. In the heart lung preparation (HLP) of the guinea pig 2.5 ml rat serum anaphylatoxin (AT) released approximately ten times less histamine than was released by 5 mg ovalbumin in the sensitized HLP. In intact animals the plasma histamine increase caused by 5 ml/kg AT was not significantly different from that caused by 10 mg/kg ovalbumin. It is supposed that in AT shock extrapulmonary sources contribute to plasma histamine more than in anaphylactic shock. 2. Mepyramine maleate (40 μg/ml blood) did not significantly reduce the bronchospasm caused by AT in HLP except when a very high AT dose (0.3 ml/ml) was given. In the intact animal, mepyramine lowered the AT-induced bronchospasm by 50–65%. This effect of mepyramine is completely abolished byβ-adrenoceptive receptor blockade. 3. It is concluded that the prevalence of histamine effects in AT shock in vivo, as documented by the life saving effect of antihistamines, is due to 2 facts: influx of histamine from the organs other than the lung, and preferential antagonism by catecholamines of such shock mechanisms which are not based on histamine release.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00997283
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  • 4
    Digitale Medien
    Digitale Medien
    Methadone-induced changes in the visual evoked response recorded from multiple sites in the cat brain (1979)
    Springer
    Psychopharmacology 63 (1979), S. 89-95 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Methadone ; Visual evoked responses ; Cortical ; Subcortical ; Cats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Visual evoked responses (VERs) and EEG were recorded following the i.p. administration of five doses of methadone (0.5–4 mg/kg) to 12 adult cats, which were implanted with cortical and subcortical electrodes. Additional cats, subjected to the same drug regimen, were used to evaluate plasma methadone concentrations. Doses of methadone that produced plasma concentrations between 80 and 190 ng/ml differentially affected VERs recorded from cortical and subcortical sites. Of the subcortical structures evaluated, the limbic system, specifically the hippocampus, was the most sensitive to the effects of the drug. These effects appeared to be primarily depressant. Responses recorded from the reticular formation and centromedian were affected only by the highest dose of methadone, while VERs recorded from cortical sites were reliably altered following the two highest doses and appeared to reflect both excitation and depression. Behavioral changes, however, were clearly evidenced in some cats at lower doses of methadone. Therefore, the data suggest (1) that those structures evaluated electrophysiologically did not reflect the full force of the drug's action as evidenced by its effect on behavior, (2) that cortical and subcortical recording sites have differential sensitivities, and (3) that one clearly defined, principal site of action of methadone is absent in the cat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426927
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  • 5
    Digitale Medien
    Digitale Medien
    High-spin spectroscopy of168Hf (1987)
    Springer
    The European physical journal 327 (1987), S. 397-402 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 21.10.Re ; 23.20.Lv ; 27.70.+ q
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The nucleus168Hf was studied up to spin (38+) in the yrast band and to spins (41−) and (38−) in the lowest two negative-parity bands. The onset of a proton alignment (h9/2 or i13/2 quasiparticles) is observed in these three bands for the highest transitions. A new band with even spins and negative parity was found. The interaction strength between the ground-state band and theAB band is measured.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01289564
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  • 6
    Digitale Medien
    Digitale Medien
    Eni naturwissenschaftliches Literaturkarussell. Biologie (1993)
    Weinheim : Wiley-Blackwell
    Chemie in unserer Zeit 27 (1993), S. III 
    Details
    ISSN: 0009-2851
    Schlagwort(e): Chemistry ; Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ciuz.19930270209
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  • 7
    Digitale Medien
    Digitale Medien
    Disproportionierung der Sulfinsäuren und die Struktur der Sulfinsäureanhydride (1958)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 70 (1958), S. 268-269 
    Details
    ISSN: 0044-8249
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ange.19580700904
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  • 8
    Digitale Medien
    Digitale Medien
    Synthesis and properties of a cellulose exchanger with the crown ether diaminodibenzo-17-crown-5 as anchor group (1995)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 227 (1995), S. 101-110 
    Details
    ISSN: 0003-3146
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Beschreibung / Inhaltsverzeichnis: Ein Cellulose- Austauscher wurde aus “o-Aminophenol-Cellulose” durch Diazotieren und Kuppeln mit Diaminodibenzo-17-krone-5 hergestellt. Die Verteilungskoeffizienten für Ca2+, Sr2+, Ba2+, Na+ und K+ wurden in Wasser/Methanol-Mischungen als Funktion des Wassergehaltes bestimmt. Die Trennung von Ca2+, Na+ und K+ und die Fraktionierung der Calciumisotope 48Ca und 40Ca wurde untersucht. Der Anreicherungsfaktor ε = 4.9 · 10-3 für 48Ca2+ ist merklich größer als der für Kationenaustauscher mit SO3H-Gruppen gefundene, aber niedriger als der in der Literatur für bestimmte Kryptanden angegebene Wert.
    Notizen: A new cellulose exchanger was synthesized from “o-aminophenolcellulose” by diazotation and coupling with diaminodibenzo-17-crown-5. The distribution coefficients for Ca2+, Sr2+, Ba2+, Na+ and K+ were determined in water/methanol mixtures as a function of the water content. Separation of Ca2+, Na+ and K+ and fractionation of the calcium isotopes 48Ca and 40Ca were investigated. The enrichment factor ε = 4.9 · 10-3 for 48Ca2+ is appreciably higher than that found for cation exchange resins with —SO3H groups, but lower than that reported for certain cryptands.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/apmc.1995.052270110
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