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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of pine cone extract fraction VI with mutagens
    Amsterdam : Elsevier
    Mutation Research/Reviews in Genetic Toxicology 297 (1993), S. 53-60 
    Details
    ISSN: 0165-1110
    Keywords: 2-Aminoanthracene ; Ames test ; Antimutagenicity ; Benzo[a]pyrene ; Hepatic microsomal enzymes ; Pine cone extract fraction VI
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0165-1110(93)90007-A
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  • 2
    Electronic Resource
    Electronic Resource
    De- and remyelination and onion bulb in cerebrotendinous xanthomatosis (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 43-45 
    Details
    ISSN: 1432-0533
    Keywords: Cerebrotendinous xanthomatosis ; Segmental demyelination ; Remyelination ; Sural nerve ; Onion bubl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a case of cerebrotendinous xanthomatosis (CTX), confirmed biochemically and histologically, quantitative histological studies of the biopsied sural nerve revealed significantly higher incidence of de- and remyelination and onion bulb than in controls. The density of total myelinated fibers fell within the range of controls, although the density of large myelinated fibers seemed to be slightly decreased. It was suggested that the preferential involvement of the myelin sheath and Schwann cell may exist in CTX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691803
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  • 3
    Electronic Resource
    Electronic Resource
    Spinal cord multiple sclerosis lesions in Japanese patients: Schwann cell remyelination occurs in areas that lack glial fibrillary acidic protein (GFAP) (1985)
    Springer
    Acta neuropathologica 65 (1985), S. 217-223 
    Details
    ISSN: 1432-0533
    Keywords: Multiple sclerosis ; Schwann cell ; Remyelination ; Glial fibrillary acidic protein ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To extend earlier observations on Schwann cell remyelination in multiple sclerosis (MS) lesions (Itoyama et al. 1983) we immunostained spinal cord sections from eight Japanese MS patients with antiserum to Po glycoprotein, a major constituent of peripheral nervous system (PNS) myelin, myelin basic protein (MBP), and glial fibrillary acidic protein (GFAP). Spinal cord sections from six of the eight Japanese MS patients contained large clusters of peripheral myelin sheaths with anti-Po immunoreactivity. In lesions found in four of the six patients, thousands of Po-stained PNS myelin sheaths were present. Necrosis was prominent in these lesions which included more than half of the spinal cord's transverse area. The number and density of regenerating myelin sheaths of peripheral origin were much greater than we observed in MS spinal cord lesions of white people (Itoyama et al. 1983). Anti-GFAP immunoreactivity was present in most brain and spinal cord lesions. However, the areas in lesions that contained large groups of PNS myelin sheaths lacked anti-GFAP immunoreactivity. Our data suggest that spinal MS lesions that are large, severely demyelinated, and partially necrotic may contain factors that inhibit fibrous astrogliosis. These factors, other substances in the large lesions and/or the lack of astrocytic scarring could then promote Schwann cell invasion, multiplication, and remyelination of surviving axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687001
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of adrenalectomy, pretreatment with SKF 525-A, phenobarbital and diethyl maleate on the acute toxicity of fenitrothion in male rats (1983)
    Springer
    Archives of toxicology 52 (1983), S. 233-242 
    Details
    ISSN: 1432-0738
    Keywords: Fenitrothion ; Fenitrooxon ; Acute toxicity ; Phenobarbital ; Adrenalectomy ; Diethyl maleate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of adrenalectomy (Adx), SKF 525-A, phenobarbital (PB), and diethyl maleate (DEM) on the acute toxicity of fenitrothion was investigated in male rats by assessing the degree of plasma cholinesterase activity. PB, 60 mg/kg/day for 3 days, exerted no protective effect on the toxicity of fenitrothion (100 mg/kg, p.o.) given 24 h after the last injection. In adrenalectomized and SKF 525-A-pretreated rats, the toxicity of fenitrothion was lower than that of the controls. Fenitrothion toxicity was increased by administration of DEM (1 ml/kg), which depletes hepatic glutathione (GSH) levels. In vitro, the rates of fenitrothion decomposition and fenitrooxon formation by microsomes were markedly affected by PB, SKF 525-A and Adx. The decomposition of fenitrooxon by the microsomal fraction and GSH-dependent decomposition of fenitrooxon by the soluble fraction were not affected by PB, SKF 525-A and Adx pretreatment. The GSH-dependent decomposition of fenitrothion and fenitrooxon was increased by addition of GSH to the incubation mixture. The present results indicate that the GSH-dependent metabolic pathway plays an important role in the detoxication of fenitrothion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333902
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