ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

The gastric cytoprotective action of adenosine and prostaglandin E2 in rabbits (1994)

Cho, C. H. ; Chen, B. W. ; Luk, C. T. ; [et al.]

Springer

Inflammation research 42 (1994), S. 146-148

add to mindlist on the mindlist

Details

ISSN: 1420-908X

Keywords: Adenosine ; Prostaglandin E2 ; Gastric gland ; Damage

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The direct protective action of adenosine and prostaglandin E2 (PGE2) was examined in an isolated gastric gland preparation in rabbits. Ethanol, (8%, v/v) incubation markedly increased the release of lactate dehydrogenase (LDH) and number of non-viable glands in the preparation. Both effects were prevented by PGE2 preincubation in a concentration (10−6, 1.4×10−5 or 2.8×10−5 M)-dependent manner. The protective action was smaller in adenosine-treated groups, and yet the highest concentration (10−4 M) of the compound also significantly inhibited the cytotoxic effects of ethanol. These findings indicate that both adenosine and PGE2 possess cytoprotective action on gastric glands in rabbits, but the former compound exerts its action beyond physiological concentrations. It is concluded that endogenous PGE2, but not adenosine may act as an ulcer modulator in the stomach.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01983481

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Heparinized polyurethanes: In vitro and in vivo studies (1985)

Heyman, P. W. ; Cho, C. S. ; McRea, J. C. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 19 (1985), S. 419-436

add to mindlist on the mindlist

Details

ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Heparin immobilization chemistry using alkyl spacer arms was adapted to optimize yield on polyurethane (PU) surfaces. The resultant biological activity of immobilized heparin (HI) was examined in vitro and in vivo, and compared with a heparin releasing (HR) system. Immobilized heparin retained its ability to bind and inactivate thrombin and Factor Xa; nonspecific coagulation factor binding was insignificant. Such activity cannot be attributed to the leakage of improperly bound heparin. Immobilized heparin-polurethane catheters implanted in canine femoral and jugular veins for 1 h periods exhibited significant reduction in thrombus formation compared with untreated PU contralateral controls. Polyurethane catheters coated with a 9% heparin dispersion in PU (HR) system provided even greater improvement in antithrombogenicity.

Additional Material: 5 Ill.