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  • 1
    Electronic Resource
    Electronic Resource
    The normal pituitary examined with positron emission tomography and (methyl-11C)-L-methionine and (methyl-11C)-D-methionine (1987)
    Springer
    Neuroradiology 29 (1987), S. 221-225 
    Details
    ISSN: 1432-1920
    Keywords: Positron emission tomography ; Brain metabolism ; Amino acids ; Stereospecificity ; Pituitary gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (methyl-11C)-L-methionine. On a following day the examination was repeated with (methyl-11c)-D-methionine. The accumulation rate of L-methionine in the pituitary was measured, giving a value that was about twice that of normal brain tissue. The accumulation rate of D-methionine in the pituitary was almost a factor of 10 lower than that of L-methionine. In the normal brain tissue that ratio was 2.3. The study clearly indicates that the methionine uptake in the pituitary is stereospecific. 11C-D-methionine is freely distributed in the tissue without entrapment, whereas 11C-L-methionine is irreversibly bound. It is concluded that PET with 11C-L-methionine can be used to study amino acid utilization in the pituitary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451757
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Attenuation profiles of the petrous bone with acoustic neuroma (1980)
    Springer
    Neuroradiology 19 (1980), S. 123-129 
    Details
    ISSN: 1432-1920
    Keywords: Computed tomography ; Acoustic neuroma ; Internal auditory meatus ; Attenuation profiles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Attenuation profiles across the petrous bone covering the whole internal auditory meatus (IAM) were constructed from the printouts obtained by computed tomography (CT) with narrow collimation performed on 12 patients with 13 acoustic neuromas. In healthy patients the attenuation profiles of right and left petrous bone were very similar in shape. The attenuation values of the individual pixels in the pixel columns of the printout located at the site of the porus and the IAM reflected the demineralization of the petrous bone and the widening of the porus and the IAM caused by the acoustic neuroma. A widening deep in the meatus was demonstrated in a patient with an intracanalicular tumor, and therefore it seems possible to make this diagnosis by CT scanning combined with the construction of attenuation profiles across the petrous bone. In the presence of unilateral acoustic neuroma there was a significant and characteristic difference in shape between the attenuation profiles of the two sides with generally lower attenuation values on the tumor side together with signs of widening of the porus and the IAM. In cases of bilateral acoustic neuroma comparison of the attenuation profiles can be made with mean attenuation curves obtained from scanning normal petrous bones. The prevailing physical limitations for demonstrating a narrow bony canal like the IAM with CT was experimentally analyzed using bone-simulating plastic material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342386
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    Paper (German National Licenses)
    Fulltext
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