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  • 1
    Electronic Resource
    Electronic Resource
    Datenschutz innerhalb des länderübergreifenden Deutschen Zentralregisters für kindliche Hörstörungen (1998)
    Springer
    HNO 46 (1998), S. 339-345 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Datenschutz ; Datensicherheit ; Medizinische Register ; Datenerhebung ; Kindliche Hörstörungen ; Key words Medical registries ; Data collection and security ; Hearing loss and childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The German Registry for Hearing Loss in Children (DZH) processes nationwide data from audiological centers. Coping with the accrued data and its subsequent management and analysis requires a high degree of security and control. To establish a nationwide registry it is necessary at an early stage to take into consideration the legal requirements of the participating states. Use of the DZH as an example demonstrates how a pragmatic solution can be reached. Special issues concerning data collection, transfer, storage and deletion, coding strategies to ensure anonymity, checking for duplicate entries, data separation, and automated data analysis and data protection are explained.
    Notes: Zusammenfassung Das Deutsche Zentralregister für kindliche Hörstörungen (DZH) verarbeitet bundesweit Daten von verschiedenen audiologischen Einrichtungen. Die Bewältigung der anfallenden Datenmengen, die nachfolgende Datenverwaltung und -analyse erfordern neben einer differenzierten und kontrollierbaren Verarbeitung ein Höchstmaß an Datensicherheit. Vor allem die länderübergreifende Struktur eines Registers erfordert schon bei der Planung engste Zusammenarbeit mit dem zuständigen Landesdatenschutzbeauftragten und auch mit den Landesdatenschutzbeauftragten anderer beteiligter Bundesländer. Am Beispiel des DZH wird demonstriert, wie eine kooperative Zusammenarbeit pragmatisch realisiert werden kann. Besonderheiten bei der Datenerhebung, Datentransfer, Speicherung und Löschung von Daten, technische Datenschutzmaßnahmen, Sicherstellung von Anonymität durch Codierungsstrategien, Duplikatsprüfung, Datentrennung und automatisierte Datenauswertung werden an Beispielen erläutert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050249
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  • 2
    Electronic Resource
    Electronic Resource
    Wird die Diagnose bei persistierenden kindlichen Hörstörungen immer noch zu spät gestellt? (1998)
    Springer
    HNO 46 (1998), S. 598-602 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Diagnosezeitpunkt ; Verzögerte Diagnose ; Medizinische Register ; Datenerhebung ; Kindliche Hörstörungen ; Key words Age at diagnosis ; Delay of diagnosis ; Medical registries ; Data collection ; Hearing loss in childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Since 1994, the German Registry for Hearing Loss in Children has registered data of 1500 children and by now can present results concerning the age at diagnosis of permanent hearing loss in children in Germany. The mean age at diagnosis is still very high. There is a strong correlation between age at diagnosis and degree of hearing loss, i.e., severe and profound hearing loss, is diagnosed distinctly earlier than mild and moderate hearing loss. On average, mild hearing loss is diagnosed with 6.2 years, moderate h.l. with 4.4 years, severe hearing loss with 2.5 years and profound hearing loss with 1.9 years. This corresponds with the results of regional German studies. At least regionally, in other European countries the age at diagnosis is known to be distinctly lower. In 36% of the children registered in Germany the delay between first suspicion and diagnosis of permanent hearing loss is 1 year or more.
    Notes: Zusammenfassung Das Deutsche Zentralregister (DZH) für kindliche Hörstörungen hat seit 1994 Patientendatensätze von 1500 Kindern erfaßt und kann mittlerweile u.a. Aussagen und Ergebnisse zum Diagnosezeitpunkt persistierender kindlicher Hörstörungen in der Bundesrepublik Deutschland vorlegen. Nach wie vor ist das mittlere Alter bei der Diagnose persistierender kindlicher Hörstörungen sehr hoch. Das Diagnosealter korreliert stark mit dem Grad der Hörstörung, d.h. an Taubheit grenzende und hochgradige Hörstörungen werden deutlich früher diagnostiziert als leichte und mittlere. So werden leichte Hörstörungen im Durchschnitt erst mit 6;2 Jahren diagnostiziert, mittlere mit 4;4 Jahren, hochgradige mit 2;5 Jahren und an Taubheit grenzende mit 1;9 Jahren. Dies entspricht den Ergebnissen bereits vorliegender regionaler deutscher Studien [1–2]. Aus anderen europäischen Länderen sind zumindest regional deutlich frühere Diagnosezeitpunkte bekannt [3–5]. Bei 36% der im DZH erfaßten Kinder liegt zwischen dem ersten Verdacht auf Vorliegen einer persistierenden kindlichen Hörstörung und der Sicherstellung der Diagnose ein Jahr und mehr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050279
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  • 3
    Electronic Resource
    Electronic Resource
    Elucidation of some fragmentations of small peptides using sequential mass spectrometry on a hybrid instrument (1989)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 3 (1989), S. 217-221 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Sequential daughter-ion-scanning analyses of small peptides have been performed using a hybrid tandem instrument of BEqQ configuration. Precursor ions are selected by B and allowed or induced (by high-energy collisional activation) to decompose in the region preceding E. Decoupling of E from the accelerating voltage permits the selection of the first-generation daughter ion whilst retaining appropriate float voltages for the quadrupole assemblies. The daughter ion selected by E is further subjected to low-energy collisional-activation dissociation (CAD) in q and the fragment-ion spectrum is obtained by scanning Q. The sequential daughter-ion-scanning technique has been used to establish that ‘internal’ fragments of the types, (AY′) and (BY′), are formed via initial Y-type cleavage. Fragmentation of a protonated peptide (angiotensin III) by loss of the C-terminal amino acid residue, yielding a (Bn′ + OH) ion, is reported for the first time. This process is analogous to that previously described for metal-cationized peptides.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290030704
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  • 4
    Electronic Resource
    Electronic Resource
    Thermolysis chemical ionzation of a complex polar lipid (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 356-358 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Vaporization of a ornithine-containing polar lipid from Thiobacillus thiooxidans has been accomplished by thermolysis in a chemical ionization source. The thermolysis has been shown to be more extensive than previously thought. It occurs in at least two steps, the first being dehydration of the ornithine to produce a substituted piperidone. This fragment undergoes a facile elimination to produce two neutral lipid components: a long chain fatty acid and piperidone-containing fatty amide. The results demonstrate the utility of chemical ionization for developing an understanding of a thermolysis process.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060810
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  • 5
    Electronic Resource
    Electronic Resource
    The internal energy of product ions formed in mass spectral reactionsMetastable Ion Characteristics, XXIII. Part XXII, F. W. McLafferty, P. F. Bente, III, R. Kornfeld, S.-C. Tsai and I. Howe, J. Amer. Chem. Soc. 95, 2120 (1973). (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1974), S. 525-535 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Major factors which determine the distribution of internal energy of a primary product ion A+, P(E)A+, at formation are delineated in terms of the quasi-equilibrium theory and a variety of experimental evidence is offered to support these conclusions. These major factors include: the P(E) of the molecular ion, the rate constants as a function of energy, κ(E), for M+·→A+ + N0 and for competing reactions of M+·, and the partitioning of excess internal energy between A+ and N0. The ‘fluctuation effect’ on this partitioning makes P(E)A+ relatively insensitive to many structural and energy changes.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210090510
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  • 6
    Electronic Resource
    Electronic Resource
    Regiospecificity for water elimination. A mass spectral study of 1-tetralol and 2-tetralol (1977)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 12 (1977), S. 55-62 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to provide a comparison with the extensive research on the mechanism for elimination of water from various cyclohexanols, the mass spectra of 1-tetralol(1,2,3,4,-tetrahydro-1-naphthalenol) and 2-tetralol(1,2,3,4-tetrahydro-2-naphthalenol) have been investigated. Deuterium labeling experiments show that the 1-tetralol molecular ion expels water by a highly specific 1,4 elimination, whereas 2-tetralol undergoes a 1,3 elimination. Both of these processes are competitive with cycloreversion reactions. The ionization potentials and appearance potentials for the major fragments \documentclass{article}\pagestyle{empty}\begin{document}$ \left[{{\rm M - H}_{\rm 2} {\rm O}} \right]_{}^{_.^ + } $\end{document} and the cycloreversion products hae been measured using the Electron Distribution Difference method. In addition, the kinetic energy release in the metastable decompositions to lose water have been measured. It has been found that the 1,4 elimination for 1-tetralol releases over 50% of the available energy in the transition state, which is unexpected in view of the 6-membering ring transition state involved. This research also includes an investigation of the nature of the various \documentclass{article}\pagestyle{empty}\begin{document}$ \left[{{\rm C}_{{\rm 10}} {\rm H}_{{\rm 10}} } \right]_{}^{_.^ + } $\end{document} ions formed in the rearrangement reaction to lose water.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210120202
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  • 7
    Electronic Resource
    Electronic Resource
    A field ionization and collisionally activated dissociation/charge stripping study of some [C9H10]+· ions (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1983), S. 16-21 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The extent of isomerization of [C9H10]+· ions, with lifetimes of approximately 10-11 and 10-6 s has been investigated using field ionization, collisionally activated dissociation and charge stripping techniques. The [C9H10]+· ions which were investigated included the molecular ions of α-methylstyrene, β-methylstyrene, o-methylstyrene, m-methylstyrene, p-methylstyrene, indan, cyclopropylbenzene, allylbenzene and the product of water loss from 3-phenylpropanol. The field ionization spectra of all the C9H10 hydrocarbons were different indicating that isomerization to a common ion structure had not occurred to a measurable extent for ions with lifetimes of approximately 10-11 s. Collisionally activated dissociation and charge stripping results indicated that most of the [C9H10]+· ions continued to maintain unique ion structures (or mixtures of structures) at ion lifetimes of 10-6 s. Possible exceptions are the [C9H10]+· ions from allylbenzene and cyclopropylbenzene which gave indistinguishable collisionally activated dissociation and charge stripping spectra.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210180105
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  • 8
    Electronic Resource
    Electronic Resource
    A Study of C5H10 radical cations by collisionally activated dissociation, charge stripping, and low energy ion-molecule reactions (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1983), S. 239-244 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: C5H10 radical cations generated from a variety of olefins and cycloalkanes were investigated by collisionally activated dissociation, charge stripping, and low energy ion-molecule reactions. It has been determined that all of the isomers studied can be distinguished by charge stripping, whereas collisionally activated dissociation and the ion-molecule reactions are less informative. The radical cations from cyclopentane, methylcyclobutane and substituted cyclopropanes retain their cyclic structures for at least a fraction of the population having lifetimes in the microsecond range.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210180604
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  • 9
    Electronic Resource
    Electronic Resource
    A mass spectrometry/mass spectrometry investigation of the nature of [C10H10]+·, [C9H7]+ and [C10H8]+· gas phase ions (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1983), S. 542-546 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Additional evidence for the rearrangement of the 1- and 3-phenylcyclobutene radical cations, their corresponding ring-opened 1,3-butadiene ions and 1,2-dihydronaphthalene radical cations to methylindenetype ions has been obtained for the decomposing ions by mass analysed ion kinetic energy spectroscopy (MIKES). The nature of the [C9H7]+ and [C10H8]+· daughter ions arising from the electron ionization induced fragmentation of these [C10H10]+· precursors has been investigated by collisionally activated dissociation (CAD), collisional ionization and ion kinetic energy spectroscopy. The [C9H7]+ produced from the various C10H10 hydrocarbons are of identical structure or an identical mixture of interconverting structures. These ions are similar in nature to the [C9H7]+ generated from indene by low energy electron ionization. The [C10H8]+· ions also possess a common structure, which is presumably that of the maphthalene radical cation.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210181210
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  • 10
    Electronic Resource
    Electronic Resource
    The ring opening of the benzocyclobutene radical cation (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1984), S. 519-520 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210191014
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