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  • 1
    Electronic Resource
    Electronic Resource
    Interaction of 5-fluorouracil with sodium poly-α,L-glutamate (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 682-685 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluorouracial ; sodium poly-α ; L-glutamate ; interaction ; viscosity ; 5-trifluoromethyluracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and its correlations in terms of chemical structure and the potentiactive drug activity. The interaction of 5-fluorouracil (5-fluorouracil is used as an anticancer drug) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on the polymer were calculated. It is very interesting that the value ofΔH0 of the binding of 5-fluorouracil with sodium poly-α,L-glutamate is smaller than that of 5-trifluoromethyluracil (although 5-trifluoromethyluracil is not used as an anticancer drug, the compound has a similar structure to 5-fluorouracil).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419893
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  • 2
    Electronic Resource
    Electronic Resource
    Diffusion coefficients of anticancer drugs and compounds having a similar structure at 30 °C (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 70-73 
    Details
    ISSN: 1435-1536
    Keywords: Diffusion coefficient ; Anticancer drug ; Uracil ; Diffusion cell method and Uridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The measurement of the diffusion coefficients of anticancer drugs and compounds having a similar structure in aqueous solution at 30 °C are carried out and the effect of some groups affecting the diffusion coefficients is investigated. The measurements of viscosity are also carried out in order to obtain the viscosity coefficient. The radius of molecule from the diffusion coefficients is in agreement with the value from the viscosity measurements. Under the concentration range studied, it seem that these compounds have a same state, for example, monomer or dimer. However, from Van der Waals radius of the results obtained, these solutes are monomer state. In spite of a large size, the diffusion coefficient of Uridine-5′-monophosphoric acid indicates a high value because of the potential gradient occurs in diffusion. From the result, 5-fluoro-2′-deoxy-5′-monophosphoric acid diffuses quickly in human body in spite of the large molecular weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411520
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Calpain activates two transglutaminases from porcine skin (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 380-384 
    Details
    ISSN: 1432-069X
    Keywords: Calpain ; Transglutaminase ; Thrombin ; Dimethyl sulfoxide ; Heating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two transglutaminases (TGase) with estimated molecular weight of 55,000 (55-K TGase) and 120,000 (120-K TGase) were partially purified from the cytosolic fraction of porcine skin (epidermis-rich preparation) using DEAE-cellulose and gel-filtration chromatographies. The enzyme activities of both trans-glutaminases were enhanced more than 20-fold by treatment with calpain (Ca2+-dependent cysteine proteinase) in the presence of Ca2+, and this enhancement was inhibited by adding EDTA, leupeptin, or an endogenous calpain-specific inhibitor protein (calpastatin). 55-K TGase was effectively activated by a smaller amount of calpain than was 120-K TGase, while known activating reagents such as thrombin and dimethyl sulfoxide or heat treatment preferentially activated 120-K TGase. One of the physiological functions of calpain in the epidermis may be the activation of epidermal transglutaminases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426618
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  • 4
    Electronic Resource
    Electronic Resource
    Human epidermis contains coagulation factor XIII (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 65-67 
    Details
    ISSN: 1432-069X
    Keywords: Transglutaminase ; Factor XIII ; Human epidermis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505647
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction of 5-trifluoromethyluracil with sodium poly-α,L-glutamate (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 467-470 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluoromethyluracil ; Sodium poly-α,L-glutamate ; Interaction ; Viscosity ; 1-(2-tetrahydrofuryl)-5-fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and to the correlations in term of chemical structure and the potentiactive drug activity. The interaction of 5-trifluoromethyluracil (although 5-trifluoromethyluracil do not used as anticancer drug, the structure of the compound has similar structure with 5-fluorouracil) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. It is very interesting that the value ofδH
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419829
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Interaction of 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate (1981)
    Springer
    Colloid & polymer science 259 (1981), S. 350-353 
    Details
    ISSN: 1435-1536
    Keywords: Anticancer drug ; 1-(2-tetrahydrofuryl)-5-fluorouracil ; Sodium poly-α ; L-glutamate ; Interaction ; Viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Die Wechselwirkung zwischen 1-(2-Tetrahydrofuryl)-5-fluorouracil und Na-Poly-α,L-glutamat wurde mit den Methoden der Spektroskopie und der Viskositätsmessung untersucht. Aus den Bindungsdaten wurden die molare Änderung von Entropie und Enthalpie und die Zahl der Brückenstellen des Polymeren berechnet. Der Wert von ΔG° beträgt ca. −10 Kcal/mol. Die Affinität ist also sehr groß.
    Notes: Summary The interaction of an anticancer drug, 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. The standard affinity of 1-(2-tetrahydrofuryl)-5-fluorouracil is about −10 kcal/ol with sodium poly-α,L-glutamate. The affinity is also very high.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01524715
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