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  • 1990-1994  (2)
  • Barrett's esophagus  (1)
  • Diffuse peritonitis  (1)
  • 1
    ISSN: 1432-0460
    Schlagwort(e): Barrett's esophagus ; Gastroesophageal reflux ; Adenocarcinoma ; High grade dysplasia ; Deglutition ; Deglutition disorders
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Barrett's esophagus (i.e. columnar epithelial metaplasia in the distal esophagus) is an acquired condition that in most patients results from chronic gastroesophageal reflux. It is a disorder of the white male in the Western world with a prevalence of about 1/400 population. Due to the decreased sensitivity of the columnar epithelium to symptoms, Barrett's esophagus remains undiagnosed in the majority of patients. Gastroesophageal reflux disease in patients with Barrett's esophagus has a more severe character and is more frequently associated with complications as compared with reflux patients without columnar mucosa. This appears to be due to a combination of a mechanically defective lower esophageal sphincter, inefficient esophageal clearance function, and gastric acid hypersecretion. Excessive reflux of alkaline duodenal contents may be responsible for the development of complications (i.e., stricture, ulcer, and dysplasia). Therapy of benign Barrett's esophagus is directed towards treatment of the underlying reflux disease. Barrett's esophagus is associated with a 30- to 125-fold increased risk for adenocarcinoma of the esophagus. The reasons for the dramatic rise in the incidence of esophageal adenocarcinoma, which occurred during the past years, are unknown. High grade dysplasia in a patient with columnar mucosa is an ominous sign for malignant degeneration. Whether an esophagectomy should be performed in patients with high grade dysplasia remains controversial. Complete resection of the tumor and its lymphatic drainage is the procedure of choice in all patients with a resectable carcinoma who are fit for surgery. In patients with tumors located in the distal esophagus, this can be achieved by a transhiatal en-bloc esophagectomy and proximal gastrectomy. Early adenocarcinoma can be cured by this approach. The value of multimodality therapy in patients with advanced tumors needs to be shown in randomized prospective trials.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Langenbeck's archives of surgery 377 (1992), S. 89-93 
    ISSN: 1435-2451
    Schlagwort(e): Diffuse peritonitis ; Programmed relaparotomy ; Prognostic factors ; Univariate, multivariate analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Anhand cities Patientenkollektivs von 184 Patienten mit diffuser Peritonitis wurden 46 Variablen in einer uni- und multivariaten Analyse auf ihre prognostische Relevanz für das Überleben der Patienten überprüft. Dabei zeigten in der univariaten Analyse folgende Parameter eine signifikante Korrelation mit dem Verlauf: Lebensalter ≥70 Jahre, heptatogene und kardiale Vorerkrankung, nicht erfolgte Fokussanierung bei 1. Operation wegen Peritonitis, Kreislaufinstabilität, pulmonales Versagen, Hyperbilirubindmie, Thrombozytopenie, erhöhtes Serumkreatinin und eingeschränkte Kreatinin-Clearance zu Behandlungsbeginn sowie der Nachweis von Pseudomonas aeruginosa im Peritonealexsudat und von Candida albicans hämatogen im Therapie verlauf. In der multivariaten Analyse erwiesen sich in hierarchischer Ordnung die chirurgische Fokussanierung bei der 1. Laparotomie wegen Peritonitis, das Serumkreatinin bei Krankheitsbeginn, Patientenalter ≥70 Jahre und die hepatogene Vorerkrankung als unabhängige Variable mit signifikanter prognostischer Relevanz für das Überleben der Patienten.
    Notizen: Summary In order to evaluate their prognostic relevance for survival 46 variables were submitted to univariate as well as multivariate analysis in a group of 184 patients with diffuse peritonitis. In the univariate analysis a significant correlation with the outcome was found for the following parameters: age ≥ 70 years, preexisting hepatic or cardiac disease, no eradication of the primary source of infection at first laparotomy for peritonitis, cardiovascular instability, respiratory failure, hyperbilirubinemia, thrombocytopenia, elevated serum creatinine and diminished creatinine clearance at the beginning and proof of pseudomonas aeruginosa in the peritoneal exsudate and of candida albicans in the blood culture during the course of the peritonitis. In the multivariate analysis the surgical eradication of the primary source of infection at the first laparotomy for peritonitis, serum creatinine at the beginning of peritonitis, age ≥ 70 years and a preexisting hepatic disease proved to be the independent variables with significant prognostic relevance for survival of the patients.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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