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  • 1
    Electronic Resource
    Electronic Resource
    Ethanol-induced increase in brain concentrations of administered neutral amino acids (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 314 (1980), S. 47-50 
    Details
    ISSN: 1432-1912
    Keywords: Ethanol ; Blood-brain barrier ; Carrier transport ; Tyrosine ; Tryptophan ; 5-Hydroxytryptophan ; α-Methyldopa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ethanol 2 g kg−1 i.p. to rat increased the concentrations in the brain of administered large neutral amino acids (tyrosine, tryptophan, 5-hydroxytryptophan and α-methyldopa). We have previously found a similar effect of ethanol on administered l-Dopa, resulting in increased brain/plasma ratios of dopa. Since large neutral amino acids are known to compete with each other for the carrier-mediated transport into the brain we suggest that the increased concentrations of the administered amino acids in the brain are at least partly the consequence of the ethanol-induced decrease in plasma amino acids observed previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498430
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Isoprenaline increases brain concentrations of administered l-dopa and l-tryptophan in the rat (1982)
    Springer
    Psychopharmacology 77 (1982), S. 98-100 
    Details
    ISSN: 1432-2072
    Keywords: l-dopa ; Tryptophan ; Brain concentration ; Isoprenaline ; Carrier transport ; Blood-brain barrier ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A small dose of isoprenaline or saline was administered intraperitoneally to rats 20 min before the administration of one of the amino acids l-dopa or l-tryptophan. Isoprenaline caused a marked increase in the brain concentration of the administered amino acid. Isoprenaline has previously been shown to cause a decrease in at least some of those plasma amino acids which compete with l-dopa and tryptophan for carrier-mediated transport into the brain. The effect of isoprenaline on the concentrations of dopa and tryptophan in the brain is suggested to be at least partly caused by a change in the relationship between endogeneous and administered amino acids. It is also possible that a direct effect of isoprenaline on the blood-brain barrier transport system contributes to the effect. The reported finding might be of clinical interest in view of the therapeutic importance of aromatic amino acids with a central site of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436106
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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