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  • 1
    Electronic Resource
    Electronic Resource
    Zur Pathophysiologie der Liquorimmunglobuline (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 806-809 
    Details
    ISSN: 1432-1440
    Keywords: CSF-immunoglobulins ; CSF-electrophoresis ; brain barrier ; Liquorimmunglobuline ; Liquorelektrophorese ; Blutliquorschranke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Immunglobuline G, A und M wurden im Liquor bei 281 Patienten bestimmt. Eine Einteilung des Krankengutes in Fälle mit entzündlichen und nichtentzündlichen Erkrankungen des ZNS erfolgte. Veränderungen der Immunglobuline in verschiedenen Bereichen des Liquorgesamteiweißes wurden verglichen. Bei höheren Gesamteiweißwerten ergab sich eine Vermehrung der Immunglobuline bei nichtentzündlichen Erkrankungen. Ein Zusammenhang dieses Befundes mit Störungen der Blutliquorschranke war anzunehmen im Gegensatz zu Veränderungen der Immunglobuline bei entzündlichen Erkrankungen des ZNS.
    Notes: Summary The immunoglobulins G, A and M in the cerebrospinal fluid were examined in 281 patients. Two groups were studied, namely cases of neurological inflammatory and non-inflammatory diseases of the central nervous system. The changes in the immunoglobulins are compared as regards total protein. It could be shown that by higher levels of total protein the immunoglobulins by non-inflammatory diseases were pathologically changed. This result was discussed in relation to the defects of the brain barrier in contrast to inflammatory changes in the immunoglobulins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468075
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 638-644 
    Details
    ISSN: 1432-1076
    Keywords: Key words HIV-1 ; T-cells ; CD69 ; Activation ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the use of a whole-blood assay that measures spontaneous and activation-induced CD69 expression on peripheral blood T-cells in vitro for assessment of T-cell function in HIV-1-infected paediatric patients. Heparinized venous blood from 28 HIV-1 positive children and adolescents and 23 healthy controls was incubated for 4 h with or without 5 μg/ml phytohaemagglutinin (PHA). Thereafter, analysis of CD69 expression on CD4+ and CD8+ T-cells was done by flow cytometry; simultaneously we determined CD4+ T-cell counts and plasma HIV-1 viral load. Neither spontaneous nor PHA-induced CD69 expression differed significantly between HIV-1 positive patients and healthy controls. However, T-cells from HIV-1 positive patients with plasma HIV-1 viral load levels above 70 × 103 copies/ml showed a higher spontaneous CD69 expression than T-cells from patients with lower plasma viral load levels in different stages of the disease. Antiretroviral treatment in four patients reduced spontaneous CD69 expression in CD4+ T-cells and PHA-induced CD69 expression in CD4+ and CD8+ T-cells significantly after 8 weeks of therapy. Conclusion Spontaneous and activation-induced expression of the early (activation) antigen CD69 on peripheral blood T-cells does not distinguish HIV-1 positive patients from HIV-1 negative healthy controls and is not correlated with peripheral blood CD4+ T-cell counts. This test may not be a reliable marker for functional T-cell deficiency during early stages of HIV disease. Increased spontaneous as well as PHA-induced CD69 expression on T-cells from HIV-1-infected children and adolescents in vitro may rather reflect HIV-induced pre-activation of T-cells in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051167
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    Paper (German National Licenses)
    Fulltext
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