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  • 1
    Electronic Resource
    Electronic Resource
    Responses of isolated canine and simian basilar arteries to thiopentone by a newly designed pharmacological method for measuring vascular responsiveness (1986)
    Springer
    Acta neurochirurgica 80 (1986), S. 57-61 
    Details
    ISSN: 0942-0940
    Keywords: Canine basilar artery ; simian basilar artery ; thiopentone ; barbiturate therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The stainless steel cannula inserting method was modified for application to observe vascular responses to thiopentone in the isolated basilar arteries of the dog and monkey. In the dog, thiopentone (0.01–3 mg) induced a monophasic vasoconstriction in a dose-dependent manner. On the other hand, in the monkey, thiopentone (0.01–3 mg) showed a biphasic vascular response,i.e., an initial vasoconstriction followed by a vasodilatation in a dose-dependent manner. Thiopentone usually produced much more potent vasoconstriction in the dog than that in the monkey, while potassium chloride made little difference of vasoconstriction between the dog and monkey basilar arteries. These findings suggest that thiopentone exerts a direct constrictive effect on cerebral vessels, the actions of which decrease the total cerebral blood volume and the brain bulk, allowing a reduction in intracranial pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809558
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mutation screening of phenylketonuria in the Far East of Russia (1999)
    Springer
    Journal of human genetics 44 (1999), S. 368-371 
    Details
    ISSN: 1435-232X
    Keywords: Key words Phenylketonuria ; Phenylalanine hydroxylase ; Mutation screening ; Far East of Russia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We analyzed mutant genotypes at the human phenylalanine hydroxylase (PAH) locus among phenylketonuria (PKU) patients in the Far East of Russia. A total of 60 variant alleles from 30 PKU families were analyzed for prevalent Caucasian mutations and restriction fragment length polymorphism/variable number of tandem repeats (RFLP/VNTR) haplotypes. Seventy-eight percent of all variant alleles carried six mutations. The most prevalent mutation was R408W (63%), with a haplotype background of 2.3. It also showed a very high degree of homozygosity (43%). The other five mutations (R158Q, R261Q, R252W, R261X, and IVS12nt-1) accounted for 1.7%–6.7% of all PKU alleles, and a single haplotype was associated with each genotype, except for R261Q. The genetic structure of PKU patients in the Far East of Russia seems to be relatively homogeneous, compared with that in the other Slavic and Oriental populations of surrounding countries. Prediction of a clinical phenotype and carrier detection will be feasible using DNA tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050180
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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