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  • 1
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 911-920 
    ISSN: 0091-3057
    Schlagwort(e): Anxiety ; Conditioned fear stress ; Dopamine ; Footshock stress ; Freezing behavior ; Medial prefrontal cortex ; Psychological stress ; Serotonin ; Stress intensity
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-2072
    Schlagwort(e): Dopamine ; Prolactin ; Lithium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Maintenance of rats on a lithium-containing diet for 3–21 days resulted in a suppression of prolactin (PRL) secretion in vivo and in vitro. Lithium treatment also resulted in an increase in the activity of tuberoinfundibular dopaminergic neurons, as evidenced by an increased accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after inhibition of DOPA decarboxylase and an increased concentration of dopamine in the anterior pituitary gland. The accumulation of DOPA in the neurointer-mediate lobe of the pituitary gland, the prefrontal cortex, the striatum and the nucleus accumbens was also enhanced by lithium treatment. It is concluded that lithium treatment enhances the synthesis of dopamine in many brain regions and that an increased activity of tuberoinfundibular dopaminergic neurons results in an enhanced inhibitory control of PRL secretion.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1435-1463
    Schlagwort(e): Lithium ; imipramine ; desipramine ; tranylcypromine ; 5-HT1A receptors ; adenylate cyclase ; hippocampus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to determine the relevance of 5-HT1A-related signal transduction in the mode of action of lithium and antidepressants, the effects of long-term treatment with these drugs on the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity were investigated in the rat hippocampal membranes. Chronic administration of antidepressants altered neither the [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding sites nor the inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT. Long-term treatment with lithium did not affect the inhibitory effect of 5-HT on the forskolin-stimulated adenylate cyclase activity, either. Neither the stimulation by forskolin nor the inhibition by guanyl-5′-ylimidodiphosphate (Gpp(NH)p) of adenylate cyclase activity was not influenced by lithium treatment, suggesting that lithium has no effects on the components of adenylate cyclase system distal to the 5-HT1A receptors. These results indicate that the 5-HT1A-mediated neural transmission has not such an important relevance in the mechanisms of action of lithium or antidepressants.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 2531-2537 
    ISSN: 0887-624X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A novel class of urea-formaldehyde condensation resins containing covalently bound metallophthalocyanine [M = A1(III), Co(II), Ni(II), or Cu(II)] was synthesized from [tetrakis(methyl-olamide)phthalocyaninato] metal complexes and dimethylolurea in aqueous solution by heating at 120°C for 10 h, followed by heating at 150°C for about 1 day. The structures of the polymers obtained were characterized by infrared and reflection electronic spectra. The thermal stabilities of the resins were evaluated by dynamic thermogravimetric analyses. The resin containing 21.3 wt % Ni(II)-metallophthalocyanine had the greatest thermal stability, with 82 wt-% char yield at 600°C in air atmosphere.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1975 (1975), S. 626-635 
    ISSN: 0075-4617
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Diazoalkane Complexes of Nickel(0) and Palladium(0) and Their Relevance to Carbenoid ReactionsA series of diazoalkane complexes with the composition ML2(diazoalkane) [M = Ni, Pd; L = tBuNC, PPh3; diazoalkane = 9-diazofluorene or diphenyldiazomethane] have been prepared and characterized, and their thermolysis and displacement reactions investigated. The nickel complexes catalyse a carbenoid reaction which leads to ketenimine formation. A carbene complex having the formula Pd(PPh3)2(C13H8) was obtained by low temperature thermolysis of Pd(PPh3)2(9-diazofluorene).
    Notizen: Eine Reihe von Diazoalkankomplexen mit der Zusammensetzung ML2(Diazoalkan) [M = Ni, Pd; L = tBuNC, PPh3; Diazoalkan = 9-Diazofluoren oder Diphenyldiazomethan] wurde dargestellt und charakterisiert; ihre Thermolyse- sowie Verdrängungsreaktionen wurden untersucht. Die Nickelkomplexe katalysieren eine Carbenoidreaktion, die zur Keteniminbildung führt. Tieftemperaturthermolyse von Pd(PPh3)2(9-Diazofluoren) lieferte einen Carbenkomplex der Zusammensetzung Pd(PPh3)2(C13H8).
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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