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  • 1
    Electronic Resource
    Electronic Resource
    Effects of nitric oxide synthesis inhibition on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in the rat brain (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 671-680 
    Details
    ISSN: 1435-1463
    Keywords: Nitric oxide (NO·) ; methamphetamine ; neurotoxicity ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined effects of nitric oxide (NO·) synthesis inhibition on methamphetamine (MA)-induced dopaminergic and serotonergic neurotoxicity. The toxic dose of MA (5 mg/kg, sc, X4) significantly decreased contents of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum (ST), and significantly decreased contents of serotonin (5-HT) in the ST, nucleus accumbens (NA) and medial frontal contex (MFC). Coadministration with a NO· synthase inhibitor, Nω-nitro-L-arginine methyl ester (LNAME) (30 mg/kg, ip, X2), reduced the MA-induced decreases in contents of DA, DOPAC and HVA in the ST, but not reduced the MA-induced decreases in contents of 5-HT in the ST, NA and MFC. These findings suggest that the MA-induced dopaminergic, but not serotonergic neurotoxicity, may be related to the neural process such as NO· formation caused by the activation of postsynaptic DA receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271227
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 227-240 
    Details
    ISSN: 1435-1463
    Keywords: Neuroleptics ; dopamine ; prolactin ; hypothalamus ; clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two atypical neuroleptic agents, clozapine and fluperlapine, produced rapid elevations in plasma PRL concentrations that were similar in magnitude to those produced by haloperidol. However, the PRL response to clozapine or fluperlapine was of much shorter duration than that elicited by haloperidol. Clozapine, but neither fluperlapine nor haloperidol, produced a rapid increase in the activity of tuberoinfundibular dopamine (TIDA) neurons, as evidenced by an enhanced accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after the inhibition of DOPA decarboxylase. The clozapine-induced increase in DOPA accumulation was evident within 30 minutes after its administration and persisted for at least 4 hours. The clozapine-induced increase in the activity of TIDA neurons may account, in part, for the abbreviated PRL response to this neuroleptic. In addition, ability to produce a short-lived increase in PRL secretion in the rat appears to be common to the atypicl neuroleptic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098500
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 97-106 
    Details
    ISSN: 1435-1463
    Keywords: Methamphetamine ; neurotoxicity ; N-methyl-D-aspartate ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40–60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244869
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  • 4
    Electronic Resource
    Electronic Resource
    Diazoalkankomplexe mit Nickel(0) und Palladium(0) und ihre Bedeutung für Carbenoidreaktionen (1975)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1975 (1975), S. 626-635 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Diazoalkane Complexes of Nickel(0) and Palladium(0) and Their Relevance to Carbenoid ReactionsA series of diazoalkane complexes with the composition ML2(diazoalkane) [M = Ni, Pd; L = tBuNC, PPh3; diazoalkane = 9-diazofluorene or diphenyldiazomethane] have been prepared and characterized, and their thermolysis and displacement reactions investigated. The nickel complexes catalyse a carbenoid reaction which leads to ketenimine formation. A carbene complex having the formula Pd(PPh3)2(C13H8) was obtained by low temperature thermolysis of Pd(PPh3)2(9-diazofluorene).
    Notes: Eine Reihe von Diazoalkankomplexen mit der Zusammensetzung ML2(Diazoalkan) [M = Ni, Pd; L = tBuNC, PPh3; Diazoalkan = 9-Diazofluoren oder Diphenyldiazomethan] wurde dargestellt und charakterisiert; ihre Thermolyse- sowie Verdrängungsreaktionen wurden untersucht. Die Nickelkomplexe katalysieren eine Carbenoidreaktion, die zur Keteniminbildung führt. Tieftemperaturthermolyse von Pd(PPh3)2(9-Diazofluoren) lieferte einen Carbenkomplex der Zusammensetzung Pd(PPh3)2(C13H8).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.197519750405
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  • 5
    Electronic Resource
    Electronic Resource
    Functional metallomacrocycles and their polymers. XXII. Thermally stable metallophthalocyanine formaldehyde condensation resins (1989)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 2531-2537 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A novel class of urea-formaldehyde condensation resins containing covalently bound metallophthalocyanine [M = A1(III), Co(II), Ni(II), or Cu(II)] was synthesized from [tetrakis(methyl-olamide)phthalocyaninato] metal complexes and dimethylolurea in aqueous solution by heating at 120°C for 10 h, followed by heating at 150°C for about 1 day. The structures of the polymers obtained were characterized by infrared and reflection electronic spectra. The thermal stabilities of the resins were evaluated by dynamic thermogravimetric analyses. The resin containing 21.3 wt % Ni(II)-metallophthalocyanine had the greatest thermal stability, with 82 wt-% char yield at 600°C in air atmosphere.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1989.080270805
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    Paper (German National Licenses)
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