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Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man (1993)

Okano, H. ; Saeki, S. ; Inui, A. ; [et al.]

Springer

Digestive diseases and sciences 38 (1993), S. 817-823

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ISSN: 1573-2568

Keywords: trimebutine maleate ; solid meal ; gastric emptying ; gallbladder emptying ; pancreatic polypeptide ; gastrin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We investigated the effect of orally administered trimebutine maleate on gastric and gallbladder emptying and on the release of gut peptide, pancreatic polypeptide (PP), and gastrin in humans for 120 min after ingestion of a solid meal. Gastric emptying was measured by a radionuclide technique. Gallbladder emptying was estimated by real-time ultrasonography. The oral administration of 200 mg of trimebutine maleate significantly shortened the lag time in starting gastric emptying (P〈0.05). Considering gallbladder emptying, trimebutine significantly inhibited the fasting emptying induced by neural reflex. Postprandially, there was a tendency toward an accelerated gallbladder emptying in the early phase. Neither the maximal percentage of gallbladder emptying nor the time of peak gallbladder emptying were affected. Trimebutine significantly blunted the postprandial PP response in the cephalic and gastric phases, reflecting a vagal-cholinergic activity (P〈0.05). The PP response in the intestinal phase was also blunted. Gastrin release was significantly augmented only during the period of fasting after drug administration (P〈0.05). The major effect of trimebutine maleate appears to be a shortening of the lag time at the start of gastric emptying probably via its anticholinergic activity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01295906

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Phase separation temperatures in the ternary system polystyrene/poly(α-methyl styrene)/cyclopentane (1986)

Saeki, S. ; Tsubotani, S. ; Kominami, H. ; [et al.]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 24 (1986), S. 325-335

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ISSN: 0887-6266

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Phase separation temperatures of the ternary system polystyrene (PS) (Mw = 1.67 × 104)/poly(α-methyl styrene) (PαMS) (Mw = 9.0 × 104)/cyclopentane with a blend ratio PS/PαMS = 55/45 have been determined over the polymer concentration range 0.02 ≤ ψPS + PαMS ≤ 0.52, where ψ PS + PαMS is the segment fraction of polymer in ternary system. Phase separation temperatures for the upper critical separation in the ternary system decrease with increasing ψ PS + PαMS over the range 0.1 ≤ ψ PS + PαMS ≤ 0.52. The vapor - liquid equilibrium in this system with a blend ratio PS/PαMS=50/50 has been determined over the concentration range 0.925 ≤ ψPS + PαMS 〈 0.995 and the temperature range 60-100°C by the piezoelectric vapor sorption method. The polymer - polymer interaction parameters χ′12 determined are positive except at 100°C and increase with increasing ψ PS + PαMS. Values of χ′12 extrapolated to zero solvent concentration are positive (0.0-1.3) over the temperature range measured. Phase separation behavior is discussed in terms of phase separation temperature in a ternary system and the polymer-polymer interaction parameter.

Additional Material: 6 Ill.