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  • 1
    Electronic Resource
    Electronic Resource
    Basale und Noradrenalin-(NA-)induzierte Lipolyse in isolierten Fettzellen des Menschen bei isocalorischer und hypocalorischer Diät (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 735-737 
    Details
    ISSN: 1432-1440
    Keywords: Isolated fat cells ; lipolysis ; starvation ; noradrenalin ; Isolierte Fettzellen ; Lipolyse ; Hunger ; Noradrenalin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An isolierten Fettzellen des abdominellen Subcutanfettgewebes übergewichtiger Patienten unter isocalorischer und hypocalorischer Diät wurde die basale Lipolyse und deren Stimulierbarkeit durch Noradrenalin untersucht. Es konnte gezeigt werden, daß unter hypocalorischen Ernährungsbedingungen die basale Lipolyse auf das 4,5fache der Norm erhöht ist, und zum Unterschied von der Lipolyse unter isocalorischer Kost durch Noradrenalin nicht mehr signifikant gesteigert werden kann. Es ist anzunehmen, daß es im Hunger zu einer maximalen Aktivität der hormonsensitiven Lipase kommt, die durch maximale Dosen von Noradrenalin nicht mehr weiter stimuliert werden kann.
    Notes: Summary In isolated human fat cells of the subcutaneous abdominal region the effect of noradrenalin on lipolysis was tested under isocaloric and hypealoric diet. It could be demonstrated that with hypocaloric diet, the basal lipolysis increased 4,5-fold and could not be further stimulated by maximal doses of noradrenalin. It is suggested that starvation results in a maximal activity of the hormone-sensitive lipase, which it is impossible to further increase by noradrenalin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468366
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of general and local anaesthesia on basal and noradrenaline-stimulated lipolysis in isolated human subcutaneous fat cells (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 335-339 
    Details
    ISSN: 1433-8580
    Keywords: General anaesthesia ; Isolated fat cells ; Lipolysis ; Local anaesthesia ; Procain hydrochloride ; Allgemeinnarkose ; Isolierte Fettzellen ; Lipolyse ; Lokalanaesthesie ; Procainhydrochlorid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In isolierten menschlichen Fettzellen des abdominellen Subcutanfettgewebes wurde der Effekt einer Allgemeinnarkose im Vergleich zur Lokalanaesthesie auf die basale und Noradrenalin-induzierte Lipolyse untersucht. Es konnte gezeigt werden, daß Procainhydrochloridin vitro stark antilipolytisch wirksam war. Präinkubation des Fettgewebes mit Procainhydrochlorid hatte keinen Einfluß auf die lipolytische Aktivität in den isolierten Fettzellen. Zwischen Allgemeinnarkose und Lokalanaesthesie bestand hinsichtlich ihres Einflusses auf die Lipolyse in isolierten Fettzellen kein signifikanter Unterschied.
    Notes: Summary In isolated human fat cells of the subcutaneous abdominal region the effect of general anaesthesia as compared to local anaesthesia on basal and noradrenaline-stimulated lipolysis has been investigated. It could be shown that procain hydrochloride exerted a marked antilipolytic action when addedin vitro. Preincubation of the whole adipose tissue with procain hydrochloride prior to the isolation procedure did not alter the lipolytic activity in the fat cells. There was no significant difference in lipolysis between fat cells obtained from patients under general anaesthesia and cells from individuals under local anaesthesia with procain hydrochloride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851520
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro human polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of aminoterminal and carboxyterminal substance P (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 340 (1989), S. 185-190 
    Details
    ISSN: 1432-1912
    Keywords: Tachykinins ; Calcitonin gene related peptide ; Neutrophils ; Monocytes ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polymorphonuclear leukocytes (PMNL) are a component of the inflammatory response to neurogenic mediators. Using the micropore filter approach, the authors studied the chemoattracting properties of tachykinins, including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), and that of calcitonin gene-related peptide (CGRP) for human PMNL in vitro and now show that SP in near nanomolar concentrations stimulates locomotion of human PMNL. Locomotion of PMNL is induced by SP, aminoterminal SP (1–9) and the SP receptor antagonist [d-pro2, d-trp7,9]-SP (DPDT) but not by carboxyterminal SP (3–11), NKA, NKB, or CGRP suggesting that the aminoterminal amino acids arginine and proline, are essential residues of SP in activation of PMNL locomotion. In contrast, the migratory effect of SP on monocytes resides in the carboxyterminal SP amino acid sequence, which is in agreement with carboxyterminal, SP receptor-mediated chemotaxis of human monocytes previously shown by others. From the known structure-activity relationships for SP receptors it is concluded that induction of PMNL migration by SP does not involve neurokinin-1 (NK-1), NK-2 or NK-3 receptors. “Checkerboard” analysis reveals that PMNL locomotion by SP is not dependent on concentration gradients and thus represents chemokinesis, which is enhancement of speed and/or frequency of locomotion. One cannot exclude that this action of SP on PMNL is mediated by the aminoterminal sequence via yet unknown SP “receptors”. Since structure-activity relationships appear to be similar to the mast cell degranulating actions of tachykinins, which also critically depend on the aminoterminal sequence, it may correspondingly be regarded as non-receptorial mechanism, due to membrane interaction of the basic groups in the N-terminal region of the peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168967
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of recombinant human growth hormone-induced and prolactin-induced activation of neutrophils by octreotide (1993)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 347 (1993), S. 336-341 
    Details
    ISSN: 1432-1912
    Keywords: Somatostatin ; Octreotide ; Neutrophils ; Raspiratory burst ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Growth hormone, prolactin and somatostatin are polypeptide hormones of the neuroendocrine and peripheral nervous systems. In vitro, these have opposing effects on cells of the immune system. We compared the effects of these peptides on activation of neutrophils using a recombinant preparation of human growth hormone, human prolactin and octreotide, a long acting analog of somatostatin. In the absence of growth hormone, octreotide did not affect either neutrophil locomotion or respiratory burst. Octreotide, however, significantly antagonized growth hormone-induced activation of neutrophils for enhanced respiratory burst as well as growth hormone-induced inhibition of stimulated migration. As the effect of growth hormone on neutrophils is mediated by the prolactin receptor, its inhibition by octreotide was also tested using prolactin as priming agent. Data indicate comparable effects of octreotide on priming of neutrophils by prolactin. The effect of octreotide was dose-dependent and appeared to be selective, as activation of neutrophil respiration burst by γ-interferon, and inhibition of stimulated migration by tumor necrosis factor-α were unaffected by octreotide. The present study suggests that octreotide may act on neutrophils directly by antagonizing growth hormone or prolactin at the cellular level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167454
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    Paper (German National Licenses)
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