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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 11 (1996), S. 398-399 
    ISSN: 1437-9813
    Keywords: Carcinoid tumor ; Malignant carcinoid syndrome ; Chemotherapy ; Liver transplantation ; Child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors report a rate case of carcinoid syndrome (CS) in a 12-year-old child that was caused by a carcinoid tumor located in the ileum that had metastasized mainly to the liver. After resection of the primary tumor, treatment with octreotide and polychemotherapy (five monthly cycles of 5-flourouracil, epidoxorubicin, and deticene) was ineffective for both reducing the metastatic liver disease and controlling the clinical symptoms. The patient's poor prognosis led the authors to perform a liver transplantation. The results of liver transplantation in patients with metastatic liver disease are generally not good. However, neuroendocrine tumors seem to be an exception due to their slow growth. At present, the child is in complete clinical and laboratory remission 4 months after transplantation. To the best of our knowledge, only 5 cases of CS have been reported to date in children.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 23 (1984), S. 157-170 
    ISSN: 1436-6215
    Keywords: Dünndarmresorption ; Tumorstadium ; histologischer Typ ; Organlokalisation ; Ernährungstherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary A deteriorating nutritional condition combined with the loss of body mass is one of the most noticeable symptoms of cancer. In order to answer the question to what extent absorption disorders in the small intestine are responsible for the malnutrition which develops, we studied 54 oncologic patients using modified D-xylose absorption tests. After the oral and intravenous administration of 10 g D-xylose at different times, the degree of absorption dependent on time was determined on the basis of a biophysical model. When accompanied by general nonspecific tumor symptoms, the frequency of absorption restrictions was increased. An established relation was found between the extent of small intestinal absorption, on the one hand, and the degree of spreading (staging) and the degree of histological differentiation of the carcinoma, on the other hand. Enteral absorption disorders represent a partial cause for the development of malnutrition in cancer patients and must be viewed as a result of a metabolic situation which is distinctly catabolic.
    Notes: Zusammenfassung Die Verschlechterung des Ernährungszustandes und die Abnahme an Körpermasse ist eines der auffälligsten Symptome des Krebsleidens. Zur Beantwortung der Frage, inwieweit Störungen der Dünndarmresorption für die sich entwickelnde Malnutrition verantwortlich zu machen sind, untersuchten wir 54 onkologische Patienten mit Hilfe des modifizierten D-Xylose-Resorptionstests. Nach zeitlich getrennter oraler und intravenöser Applikation von 10 g D-Xylose wurde auf der Grundlage einer biophysikalischen Modellierung das Ausmaß der Resorption in Abhängigkeit von der Zeit ermittelt. Mit dem Auftreten allgemeiner unspezifischer Tumorsymptome erhöht sich die Häufigkeit von Resorptionseinschränkungen. Es konnte eine gesicherte Beziehung zwischen Ausbreitungsgrad (Staging), histologischem Differenzierungsgrad des Karzinoms einerseits und dem Ausmaß der Dünndarmresorption andererseits nachgewiesen werden. Enterale Resorptionsstörungen stellen eine Teilursache bei der Entwicklung einer Mangelernährung bei Krebskranken dar und sind selbst als Folge der katabol akzentuierten Stoffwechsellage anzusehen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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