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  • 1
    Digitale Medien
    Digitale Medien
    Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)
    Springer
    Diabetologia 37 (1994), S. 1036-1043 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Key words Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU · kg−1· min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased. [Diabetologia (1994) 37: 1036–1043]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00400467
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  • 2
    Digitale Medien
    Digitale Medien
    Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)
    Springer
    Diabetologia 37 (1994), S. 1036-1043 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU·kg−1·min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00400467
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Zur Häufigkeit des latenten Diabetes in einer jugendlichen Bevölkerungsgruppe (Diagnostik, Methodik und Interpretation) (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 881-887 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Diabetes prevalence ; juvenile diabetes ; diabetes definition ; blood glucose determination ; Diabetes-Prävalenz ; jugendlicher Diabetes ; Diabetes-Definitionen ; Blutzuckerbestimmungsmethoden
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In einer jugendlichen schweizerischen Bevölkerungsgruppe wurde die Häufigkeit eines klinisch manifesten und latenten Diabetes mellitus untersucht. Diese betrug 0.06 resp. 1,7%. Die Problematik der Diabetes-Prävalenz in einer definierten Population zeigt sich nicht nur in der Anwendung bestimmter Definitions-Kriterien, sondern auch in der angewandten Methodologie. Es werden die Abweichungen der mittleren Blutzuckerwerte bei simultaner Bestimmung nach sieben verschiedenen Methoden angeführt. Es wird auf fehlende Abhängigkeiten von Alter, Gewicht, Körperoberfläche und biochemischen Parametern (Harnstoff-N, Eiweiß und Cholesterin) sowie vorgängiger Kohlenhydratzufuhr auf den Blutzuckerwert hingewiesen, wenn enzymatische Glucosebestimmungen durchgeführt werden.
    Notizen: Summary The prevalence of juvenile diabetes has been examined in a sample of a Swiss population. There was an estimate of 0.06% of clinical and of 1.7% latent diabetes in a group of males of age 20. The problems of assessing diabetes prevalence are discussed in relation to criteria of definition and blood sugar methodology. The differences of seven simultaneous determinations of blood glucose are presented. There was no dependance of fasting blood glucose values in a hospital population in relation to age, weight, body surface and chemical parameters as BUN, total proteins, cholesterol, and the previous intake of carbohydrates as long as an enzymatic glucose determination was performed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01468615
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