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  • 1
    ISSN: 1432-1440
    Keywords: Diabetes prevalence ; juvenile diabetes ; diabetes definition ; blood glucose determination ; Diabetes-Prävalenz ; jugendlicher Diabetes ; Diabetes-Definitionen ; Blutzuckerbestimmungsmethoden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer jugendlichen schweizerischen Bevölkerungsgruppe wurde die Häufigkeit eines klinisch manifesten und latenten Diabetes mellitus untersucht. Diese betrug 0.06 resp. 1,7%. Die Problematik der Diabetes-Prävalenz in einer definierten Population zeigt sich nicht nur in der Anwendung bestimmter Definitions-Kriterien, sondern auch in der angewandten Methodologie. Es werden die Abweichungen der mittleren Blutzuckerwerte bei simultaner Bestimmung nach sieben verschiedenen Methoden angeführt. Es wird auf fehlende Abhängigkeiten von Alter, Gewicht, Körperoberfläche und biochemischen Parametern (Harnstoff-N, Eiweiß und Cholesterin) sowie vorgängiger Kohlenhydratzufuhr auf den Blutzuckerwert hingewiesen, wenn enzymatische Glucosebestimmungen durchgeführt werden.
    Notes: Summary The prevalence of juvenile diabetes has been examined in a sample of a Swiss population. There was an estimate of 0.06% of clinical and of 1.7% latent diabetes in a group of males of age 20. The problems of assessing diabetes prevalence are discussed in relation to criteria of definition and blood sugar methodology. The differences of seven simultaneous determinations of blood glucose are presented. There was no dependance of fasting blood glucose values in a hospital population in relation to age, weight, body surface and chemical parameters as BUN, total proteins, cholesterol, and the previous intake of carbohydrates as long as an enzymatic glucose determination was performed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2277
    Keywords: Key words Small bowel transplantation ; Split tolerance ; FK 506 ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Functional long-term allograft survival after experimental small bowel transplantation (SBT) is limited by chronic rejection. Initial application of high-dose FK 506 has been shown to induce stable long-term graft function. In order to examine whether this long-term function is associated with donor-specific tolerance, we analyzed the functional status of recipient T cells in vivo and in vitro. One-step orthotopic SBT was performed in the allogeneic Brown Norway (BN)-to-Lewis rat strain combination. FK 506 was given daily at a dose of 2 mg/kg from days 0–5 in the rejection model and from days 0–9 in the long-term functional model. Mean survival time in the rejection model was 98 ± 2.8 days. Histological examination of these small bowel allografts disclosed signs of chronic rejection. In contrast, all animals of the long-term functional model survived long term ( 〉 250 days) without clinical signs of chronic rejection. The latter model, furthermore, produced evidence of donor-specific tolerance. Whereas heterotopic Dark Agouti (DA) hearts were rejected regularly within 7 days, BN hearts survived indefinitely ( 〉 70 days). In vitro, mixed leukocyte reactivity of CD4 + T cells was similarly strong against donor (BN) antigens as against third-party (DA) antigens. The split tolerance revealed by our in vivo and in vitro results enabled acceptance of both the small bowel allograft without signs of chronic rejection and of donor-specific heart allografts.
    Type of Medium: Electronic Resource
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