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  • 1
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1975)
    Springer
    Acta neuropathologica 32 (1975), S. 209-223 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral Ischemia ; Mongolian Gerbils ; Light Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light microscopic observations were carried out on Mongolian gerbils (Meriones unguiculatus) subjected to a partial cerebral ischemia by occlusion of the left common carotid artery at the neck. About 30% of gerbils developed an ischemic injury in the ipsilateral hemisphere and their brains revealed the following histopathologic features: 1. the changes were related to the intensity (duration) of the ischemic insult and to the time elapsed following release of the occlusion. The ischemic lesions appear to progress after re-establishment of the circulation and this presents one facet of a “maturation” phenomenon which seems to be a general principle applicable to various parameters of ischemic injury. The rate of “maturation” of the lesions is related to the intensity of the ischemic insult, a lesser intensity resulting in longer development of lesions. 2. The changes were either focal or diffuse in character. The former were assumed to be directly related to a vascular involvement; among the latter the topistic distribution of the hippocampal changes suggested a feature of selective vulnerability. 3. An indirect indication of neuronal recovery was surmised from observations on animals sacrificed after different periods following occlusions of the same duration. Also capable of recovery was a “reactive change” observed in the H3 neurons of the hippocampus. This change was characterized by central chromatolysis and resembled the “primäre Reizung” of Nissl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696570
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Secretion of Immunoreactive endothelin-1 by capillary and microvascular endothelium of human brain (1992)
    Springer
    Neurochemical research 17 (1992), S. 699-702 
    Details
    ISSN: 1573-6903
    Keywords: Endothelin-1 ; capillaries ; vasoconstrictor peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Modulation of immunoreactive endothelin-1 (IR-ET-1) production by vasoactive substances was investigated in cultured endothelial cells (EC) derived from capillaries and microvessels of human brain. Peptides, catecholamines, thrombin, protein kinase C-activating phorbol ester, and calcium ionophore enhanced the secretion of IR-ET-1. The known vasoconstrictive peptides, angiotensin II (Ang II) and arginine-vasopressin (AVP) dose-dependently stimulated the endothelial secretion of IR-ET-1. The angiotensin and vasopressin-inducible production of IR-ET-1 was completely inhibited by their respective receptor antagonists [Sar1, Ala8]-angiotensin II and [1–6 (β-mercapto-β,β-cyclopentamethylene propionic acid), 2-O-methyl-tyrosine]. The results indicate that the peptide-stimulated secretion of IR-ET-1 is receptor-mediated in EC which have specific angiotensin II and arginine-vasopressin receptors. These findings represent the first demonstration of IR-ET-1 production by capillary and microvascular endothelium of human brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968008
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    Paper (German National Licenses)
    Fulltext
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