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  • 1
    Electronic Resource
    Electronic Resource
    Construction and experimental application of a catheter for selective arterial kidney perfusion in situ (1985)
    Springer
    Urological research 13 (1985), S. 85-89 
    Details
    ISSN: 1434-0879
    Keywords: Renal protection ; Perfusion catheter ; Perfusion pressure ; Equilibration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to improve dog kidney perfusion in situ with a protective solution, a perfusion catheter was constructed which allowed continuous pressure measurement in the center of the catheter tip during perfusion. Using this catheter, the equilibration of the extracellular space with a protective solution (HTK solution) was found to be pressure dependent. Continuous pressure and resistance control is therefore a prerequisite for reliable organ protection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261572
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Short-term perfusion and “Equilibration” of canine kidneys with protective solutions (1987)
    Springer
    Urological research 15 (1987), S. 5-12 
    Details
    ISSN: 1434-0879
    Keywords: Kidney perfusion ; Equilibration ; HTK-solution ; Euro-Collins-solution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Kidneys were perfused either with Euro-Collinssolution or with HTK-solution of Bretschneider. The perfusion pressure as well as the perfusion flow were measured during a six-minute perfusion. The perfusion resistance was higher in Euro-Collins-kidneys than during HTK-perfusion. The venous outflow of the kidney as well as the ureteral outflow was measured during each minute of the perfusion and has analysed for osmolality, and for sodium and potassium concentrations. In Euro-Collins-kidneys a complete “equilibration” of the extracellular space was not achieved, while during HTK-perfusion concentrations in the venous as in the tubular outflow, similar to those in the HTK-solution itself, could be reached. At the end of the different perfusions, tissue was analysed for biochemical parameters such as ATP, ADP, AMP and lactate as well as for morphological features. Lactate had increased and ATP had decreased during perfusion with Euro-Collins-solution, while ATP had not changed and lactate had decreased during perfusion with HTK-solution. Normal glomerular, tubular and dilated vascular structures can be seen after HTK-perfusion, while a glomerular and vascular contraction takes place during Euro-Collins-perfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256327
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma renin activity in folic acid induced acute renal failure (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 797-798 
    Details
    ISSN: 1432-1440
    Keywords: Folic acid ; acute renal failure ; macula densa ; peripheral plasma renin activity ; hemorrhage ; Folsäure ; akutes Nierenversagen ; Macula densa ; periphere Plasma-Reninaktivität ; Hämorrhagie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die periphere Plasma-Reninaktivität war bei Ratten mit akutem Nierenversagen, das durch eine einmalige i.v. Injektion von Folsäure (250 mg/kg KG, gelöst in 0,3 M NaHCO3) erzeugt worden war, während der ersten 6 Std normal und nach 24 Std und 4 Tagen harabgesetzt. Hämorrhagie verursachte jedoch am 4. Tag nach Folsäuregabe einen starken Anstieg der Plasma-Reninaktivität. Für eine Beteiligung des Renins an der Entwicklung des folsäurebedingten funktionellen und morphologischen Nierenschadens ergab sich kein Anhalt.
    Notes: Summary Peripheral plasma renin activity in acute renal failure induced in rats by a single i.v. injection of folic acid (250 mg/kg b. w., dissolved in 0.3 M NaHCO3) remained normal during the first 6 hours and fell to low levels 24 hours and 4 days following the injection. Bleeding, however, induced a considerable increase of plasma renin activity on the 4th day after folate injection. There was no evidence of a participation of renin in the development of the functional and morphological renal disturbances produced by folic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490312
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Renin secretion in the earliest stage of goldblatt-type hypertension in rats (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 841-844 
    Details
    ISSN: 1432-1440
    Keywords: Early experimental renal hypertension ; renal artery constriction ; unilateral nephrectomy ; renal venous plasma renin activity ; peripheral plasma renin activity ; Frühe experimentelle renale Hypertonie ; Nierenarteriendrosselung ; einseitige Nephrektomie ; Plasma-Reninaktivität im Nierenvenenblut ; periphere Plasma-Reninaktivität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einseitige Nephrektomie und gleichzeitige Drosselung der verbliebenen kontralateralen Nierenarterie führten bei der Ratte nach 90 min zu einer signifikanten, bis zum Versuchsende (24 Std) anhaltenden Erhöhung des systolischen arteriellen Blutdruckes und zu einer vorübergehenden Zunahme der Plasma-Reninaktivität, die nach 3 Std wieder zur Norm abfiel. Einseitige Nephrektomie allein verursachte nach 90 und 180 min einen signifikanten Blutdruckabfall, nach 20 und 45 min eine geringe Steigerung der Reninaktivität im Nierenvenenblut und nach 3 Std eine bis zur 24. Std signifikant erniedrigte periphere Plasma-Reninaktivität. Eine Steigerung der Reninsekretion der „geklammerten“ Niere könnte daher für den initialen Blutdruckanstieg bei Ratten mit einer Hypertonie vom Goldblatt-Typ von Bedeutung sein.
    Notes: Summary Unilateral nephrectomy and constriction of the remaining renal artery in the rat induced a sustained increase of systolic blood pressure, which becomes significant as soon as 90 minutes after operation, and a transient rise in renal venous as well as in peripheral plasma renin activity between 20 and 180 minutes after operation. Unilateral nephrectomyper se, after 90 and 180 minutes, caused a significant fall of the systolic blood pressure, a slight increase of renal venous renin activity after 20 and 45 minutes, and between 3 and 24 hours after operation it was followed by a significant decrease of peripheral plasma renin activity. An increased secretion of renin from the “clamped” kidney may thus contribute to the initial rise of blood pressure in rats with Goldblatt-type hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496342
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    Paper (German National Licenses)
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