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  • 1
    Electronic Resource
    Electronic Resource
    Effect of indomethacin on blood pressure in rats with renovascular hypertension: Dependence on plasma renin activity (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 245-246 
    Details
    ISSN: 1432-1440
    Keywords: Volume depletion ; Renovascular hypertension ; Renin-angiotensin-system ; Blood pressure ; Prostaglandins ; Extrazelluläre Volumenrestriktion ; Renovasculäre Hypertonie ; Renin-Angiotensin-System ; Blutdruck ; Prostaglandine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei normotensiven und renal hypertensiven Ratten, die kochsalzarm oder kochsalznormal ernährt wurden, wurde der Effekt des Cyclooxygenasehemmers Indomethacin (3,4 mg/kg/24 h) auf den systolischen Blutdruck und die Plasma-Renin-Aktivität untersucht. Indometacin reduzierte die Plasma-Renin-Aktivität in kochsalzarm und kochsalznormal ernährten, normotensiven und hypertensiven Tieren. Darüberhinaus erniedrigte Indomethacin den systolischen Blutdruck in salz-arm ernährten Ratten, erhöhte jedoch den Blutdruck in salz-normal ernährten Tieren. Diese Befunde lassen vermuten, daß der Effekt von Indomethacin auf den Blutdruck von Ratten vom Extrazellulärvolumen und der Plasma-Renin-Aktivität abhängt.
    Notes: Summary The effect of the cyclooxygenase inhibitor indomethacin (3.4 mg/kg/24 hr) on systolic blood pressure (PB) and plasma-renin-activity (PRA) was evaluated in normotensive and renovascular hypertensive rats receiving either a normal or low salt diet. Indomethacin reduced PRA in normal and hypertensive animals on both low and normal salt intake. Indomethacin furthermore, decreased BP in animals on low sodium diet but increased PB in sodium repleted rats. These data suggest that the effect of indomethacin on rat BP may depend on the state of extracellular volume and PRA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476582
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  • 2
    Electronic Resource
    Electronic Resource
    Indomethacin induced hypotension in sodium and volume depleted rats (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 143-145 
    Details
    ISSN: 1432-1440
    Keywords: Indometacin ; Plasma-Reninaktivität ; Hypotonie ; Indomethacin ; Plasma Renin Activity ; Arterial Hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased. Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion.
    Notes: Zusammenfassung Nach einer einmaligen oralen Gabe von 4 mg/kg Indometacin kam es innerhalb von 4 h bei Natrium- und Volumenverarmten Ratten zu einem signifikanten Abfall der Plasma-Reninaktivität und des systolischen Blutdrucks. Bei normalen Ratten führte die Indometacingabe lediglich zur Erniedrigung der Plasma-Reninaktivität ohne Beeinflussung des arteriellen Blutdruckes. Es wird deshalb angenommen, daß Indometacin über eine Hemmung der Prostaglandinsynthese den Blutdruck stabilisierenden Effekt des Renin-Angiotensin-Systems bei Natrium- und Volumenverarmung, vermindern kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476055
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  • 3
    Electronic Resource
    Electronic Resource
    Renin secretion in the earliest stage of goldblatt-type hypertension in rats (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 841-844 
    Details
    ISSN: 1432-1440
    Keywords: Early experimental renal hypertension ; renal artery constriction ; unilateral nephrectomy ; renal venous plasma renin activity ; peripheral plasma renin activity ; Frühe experimentelle renale Hypertonie ; Nierenarteriendrosselung ; einseitige Nephrektomie ; Plasma-Reninaktivität im Nierenvenenblut ; periphere Plasma-Reninaktivität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einseitige Nephrektomie und gleichzeitige Drosselung der verbliebenen kontralateralen Nierenarterie führten bei der Ratte nach 90 min zu einer signifikanten, bis zum Versuchsende (24 Std) anhaltenden Erhöhung des systolischen arteriellen Blutdruckes und zu einer vorübergehenden Zunahme der Plasma-Reninaktivität, die nach 3 Std wieder zur Norm abfiel. Einseitige Nephrektomie allein verursachte nach 90 und 180 min einen signifikanten Blutdruckabfall, nach 20 und 45 min eine geringe Steigerung der Reninaktivität im Nierenvenenblut und nach 3 Std eine bis zur 24. Std signifikant erniedrigte periphere Plasma-Reninaktivität. Eine Steigerung der Reninsekretion der „geklammerten“ Niere könnte daher für den initialen Blutdruckanstieg bei Ratten mit einer Hypertonie vom Goldblatt-Typ von Bedeutung sein.
    Notes: Summary Unilateral nephrectomy and constriction of the remaining renal artery in the rat induced a sustained increase of systolic blood pressure, which becomes significant as soon as 90 minutes after operation, and a transient rise in renal venous as well as in peripheral plasma renin activity between 20 and 180 minutes after operation. Unilateral nephrectomyper se, after 90 and 180 minutes, caused a significant fall of the systolic blood pressure, a slight increase of renal venous renin activity after 20 and 45 minutes, and between 3 and 24 hours after operation it was followed by a significant decrease of peripheral plasma renin activity. An increased secretion of renin from the “clamped” kidney may thus contribute to the initial rise of blood pressure in rats with Goldblatt-type hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496342
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  • 4
    Electronic Resource
    Electronic Resource
    Renal hypotension in sodium and fluid deprivation: Experimental findings in renin-depleted rats (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 253-255 
    Details
    ISSN: 1432-1440
    Keywords: Renale Hypotonie ; Reninmangel ; Natriumund Volumenverarmung ; Renal hypotension ; Renin depletion ; Sodium and volume deprivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Arterial hypotension of renal origin occurred as consequence of low plasma renin activity in the presence of sodium and extracellular fluid volume depletion. Secretory insufficiency of the renin-producing juxtaglomerular cells and sodium and volume deprivation, simultaneously, were achieved by removing the “clamped” kidneys in renal hypertensive, sodium- and volume-depleted rats leaving in situ the contralateral kidneys deprived of renin during the preceding period of hypertension. It is suggested that renal hypotension after acute losses of sodium and extracellular fluid may also develop in patients with chronically depressed renin-angiotensin system.
    Notes: Zusammenfassung Eine arterielle Hypotonie renalen Ursprungs wurde als Folge einer niedrigen Plasma-Reninaktivität bei bestehendem Mangel an Natrium und extrazellulärer Flüssigkeit beobachtet. Als experimentelles Modell, an dem eine sekretorische Insuffizienz der Renin-produzierenden juxtaglomerulären Zellen und eine Natrium- und Volumenverarmung gleichzeitig erzeugt werden konnten, dienten vorher hypertone, Natrium- und Volumen-verarmte Ratten nach Entfernung der Drosselnieren und Zurücklassung der während der Hochdruckperiode Renin-verarmten contralateralen Nieren. Es wird angenommen, daß sich eine renale Hypotonie nach akuten Verlusten von Natrium und extrazellulärer Flüssigkeit auch bei Patienten mit chronisch supprimiertem Renin-Angiotensin-System entwickeln kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477833
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  • 5
    Electronic Resource
    Electronic Resource
    Tubular dimensions and Juxtaglomerular Granulation Index in rat kidneys after unilateral obstruction of the ureter (1975)
    Springer
    Urological research 3 (1975), S. 115-122 
    Details
    ISSN: 1434-0879
    Keywords: Hydronephrosis ; Tubular dimensions ; Juxta-glomerular granulation index ; Proximal convolution ; Distal convolution ; Collecting tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of ligation of a ureter on the tissues in the kidneys in male Wistar rats was studied by morphometry. Dilation of the lumen in the obstructed kidney persisted after ligation only in distal convolutions and collecting ducts. Swelling of epithelial cells in the obstructed kidney was noted only in the distal convolutions and collecting ducts. The Juxtaglomerular Granulation Index (JGI) in the obstructed kidney increased to a maximum 7 days after ligation of the ureter. In the control kidney the lumen of Bowman's space was expanded, epithelial cells in both proximal and distal parts of the nephron were swollen, and the JGI was increased after ligation of the contralateral ureter. The morphological findings support the assumption that reduced cortical blood flow and decreased intratubular flow are the cause of proximal tubular atrophy rather than a persisting increase of proximal intratubular pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256032
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