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  • 1
    Electronic Resource
    Electronic Resource
    Effect of indomethacin on blood pressure in rats with renovascular hypertension: Dependence on plasma renin activity (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 245-246 
    Details
    ISSN: 1432-1440
    Keywords: Volume depletion ; Renovascular hypertension ; Renin-angiotensin-system ; Blood pressure ; Prostaglandins ; Extrazelluläre Volumenrestriktion ; Renovasculäre Hypertonie ; Renin-Angiotensin-System ; Blutdruck ; Prostaglandine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei normotensiven und renal hypertensiven Ratten, die kochsalzarm oder kochsalznormal ernährt wurden, wurde der Effekt des Cyclooxygenasehemmers Indomethacin (3,4 mg/kg/24 h) auf den systolischen Blutdruck und die Plasma-Renin-Aktivität untersucht. Indometacin reduzierte die Plasma-Renin-Aktivität in kochsalzarm und kochsalznormal ernährten, normotensiven und hypertensiven Tieren. Darüberhinaus erniedrigte Indomethacin den systolischen Blutdruck in salz-arm ernährten Ratten, erhöhte jedoch den Blutdruck in salz-normal ernährten Tieren. Diese Befunde lassen vermuten, daß der Effekt von Indomethacin auf den Blutdruck von Ratten vom Extrazellulärvolumen und der Plasma-Renin-Aktivität abhängt.
    Notes: Summary The effect of the cyclooxygenase inhibitor indomethacin (3.4 mg/kg/24 hr) on systolic blood pressure (PB) and plasma-renin-activity (PRA) was evaluated in normotensive and renovascular hypertensive rats receiving either a normal or low salt diet. Indomethacin reduced PRA in normal and hypertensive animals on both low and normal salt intake. Indomethacin furthermore, decreased BP in animals on low sodium diet but increased PB in sodium repleted rats. These data suggest that the effect of indomethacin on rat BP may depend on the state of extracellular volume and PRA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476582
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  • 2
    Electronic Resource
    Electronic Resource
    Identification and quantitation of intact diastereoisomeric benzodiazepine glucuronides in biological samples by high-performance liquid chromatography
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 613 (1993), S. 162-167 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(93)80211-L
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  • 3
    Electronic Resource
    Electronic Resource
    Uber reaktionen von oxonium-perchloraten aus alpha, beta-ungesattigten ketonen
    Amsterdam : Elsevier
    Tetrahedron Letters 9 (1968), S. 4333-4334 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)76422-7
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1985)
    Springer
    Journal of economics 45 (1985), S. 337-355 
    Details
    ISSN: 1617-7134
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01282568
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  • 5
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    Unknown
    Buhr, W., Pauck, R.: Stadtentwicklungsmodelle (Book Review) (1985)
    Wien : Periodicals Archive Online (PAO)
    Journal of economics/Zeitschrift für Nazionalökonomie. 45 (1985) 350 
    Details
    ISSN: 0931-8658
    Topics: Economics
    Notes: Buchbesprechungen - Book Reviews
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4223-1985-045-00-000031
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  • 6
    Electronic Resource
    Electronic Resource
    Forensic significance of acetylcholine esterase histochemistry in organophosphate intoxication (1982)
    Springer
    International journal of legal medicine 89 (1982), S. 149-165 
    Details
    ISSN: 1437-1596
    Keywords: Organophosphate ; Paraoxone ; Parathion ; Acetylcholine esterase ; Organophosphate ; Paraoxon ; Parathion ; Acetylcholinesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Reduktion oder vollständige Hemmung der histochemisch nachweisbaren Acetylcholinesterase (AChE)-Aktivität nach experimentellen und spontanen (menschlichen) Organophosphatvergiftungen (besonders mittels Paraoxon = E 600 und Parathion = E 605) muß als Zeichen einer in vivo-Hemmung des cholinergen Systems interpretiert werden. Im Tierversuch wurde eine Beziehung zwischen der AChE-Aktivität und applizierten Dosis der Organophosphate nachgewiesen. In einem in vitro-System konnte die Enzymhemmung nach Exposition von AChE-enthaltenden histologischen Schnitten mit Organophosphat-enthaltenden Körperflüssigkeiten bzw. angesetzten Lösungen festgestellt werden. Bei Untersuchung der Dosisabhängigkeit wurde ferner festgestellt, daß mindestens 0.15 μg/ml Paraoxon oder 5 mg/ml Parathion notwendig sind, um in vitro die AChE zu blockieren. Bei Anwendung desselben in vitro-Systems konnte eine Halbwertzeit für das Paraoxoninaktivierende Enzym im Blut von 6–7 min nachgewiesen werden. Die in vivo und in vitro gehemmte AChE war bei anschließender Behandlung der Schnitte mit Toxogonin reaktivierbar; die Möglichkeit der Reaktivation erlaubt eine qualitative Zuordnung des AChE-hemmenden Toxins zu den Alkylphosphaten. Eine postmortale Persistenz der Enzymhemmung war am menschlichen Material für ca. 2 Monate nachweisbar. Da auch die Acetylcholinesterase in weitgehend unveränderter Aktivität nach einem postmortalen Intervall von wenigstens 70 h nachweisbar ist, muß der histochemische Nachweis als morphologisches Äquivalent einer akuten Organophosphatintoxikation angesehen werden.
    Notes: Summary The reduction of acetylcholine esterase (AChE) activity or the complete blocking of AChE to be observed by histochemical demonstration of AChE in tissue after experimental and spontaneous (human) organophosphate intoxication (especially paraoxone = E 600 and parathion = E 605) should be interpreted as an indication of an in vivo inhibition of the cholinergic system. In animal experiments, a relationship was demonstrated between AChE activity and the applied dose of organophosphorous compounds. In addition, enzyme inhibition was observed in in vitro systems using AChE-containing mouse tissue sections pretreated with organophosphate solutions or with body fluids containing organophosphates. Examination of the concentration dependency indicated that the inhibiting solution must contain at least 0.15 μg/ml paraoxone or 5 mg/ml parathion to block AChE in the section. Using the same in vitro system, a half-life of 6–7 min was established for the paraoxone inactivating enzyme in blood. The in vivo and in vitro inhibited AChE was reactivated by consecutive treatment of blocked sections with toxogonin. This possibility of reactivation therefore allows qualitative classifications of the AChE-inhibiting toxin to the alkylphosphates. The postmortem persistence of the AChE inhibitory effect was demonstrable for about a 2-month interval. Since the histochemically demonstrable activity of the enzyme AChE is more or less constant during a postmortem interval of at least 70h, the model of histochemical demonstration is a method which provides a morphological equivalent for acute organophosphate intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01873797
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  • 7
    Electronic Resource
    Electronic Resource
    Curvilinear increase in methanol concentration after inhibition of oxidation by ethanol: significance for the investigation of endogenous methanol concentration and formation (1997)
    Springer
    International journal of legal medicine 111 (1997), S. 27-31 
    Details
    ISSN: 1437-1596
    Keywords: Key words Endogenous methanol ; Concentration ; Production ; Deep compartment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Endogenous methanol production was assessed over a period of 5 h in subjects given an infusion of ethanol to inhibit methanol oxidation in the liver after a period of fasting and abstinence from alcohol. Ethanol was administered to each of five subjects at rates of 0.35 g/kg per hour and 0.70 g/kg per hour. The rise in methanol concentration was biphasic regardless of the rate of ethanol administration, with a steeper gradient in the first 10–30 min. This may be due to the existence of a deep compartment from which methanol can be displaced by ethanol. This could take the form of loose binding of methanol to the hepatic oxidation enzymes as an enzyme-substrate complex, or a shift of the oxidation-reduction equilibrium between methanol and formaldehyde. The biphasic nature of the increase, with an initial steeper rise, means that the values obtained in the first 30 min should be excluded from the calculations when the rate of endogenous methanol production is determined by linear regression analysis. Endogenous methanol concentrations to be taken into account after ethanol administration are on average 0.4–0.6 mg/kg higher than those detectable in the absence of ethanol due to the additional method displaced from the deep compartment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050106
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