Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Evidence for GABA as the synaptic transmitter of the inhibitory vestibulo-ocular pathway (1973)
    Springer
    Experimental brain research 18 (1973), S. 415-428 
    Details
    ISSN: 1432-1106
    Keywords: GABA ; Vestibulo-ocular inhibitory reflex ; Picrotoxin ; Bicuculline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper gives an account of the action of two antagonists of GABA on the vestibulo-trochlear inhibitory pathway, and of neurochemical determinations of its suggested synaptic transmitter (GABA) within the trochlear nuclei. Extra- and intracellular potentials were recorded from the trochlear nucleus following stimulation of the ipsilateral vestibular nerve, contralateral vestibular nerve and the trochlear nerve. 1. The disynaptic inhibitory vestibulo-trochlear reflex was shown to be mediated solely through the medial longitudinal fasciculus as lesion of this pathway removed it entirely. 2. Picrotoxin blocked completely the IPSP, the extracellular positive potential and the inhibitory effect on the antidromic response. 3. Bicuculline had a similar effect on the inhibitory potentials, the action was reversible lasting less than one hour at a dose less than 1 mg/kg, and the sequence of block and recovery could be repeated several times in the same experiment with a similar dose. 4. Both bicuculline and picrotoxin selectively suppressed the postsynaptic, in contrast to the presynaptic, component of the field potential, and did not markedly affect the excitatory pathway (EPSP). 5. The normal concentration of GABA in the trochlear nucleus area was 3.6 μ mole/g. After lesions of the ipsilateral medial longitudinal fasciculus the GABA content was significantly decreased suggesting degeneration of GABA containing terminals. 6. These results corroborate the hypothesis that GABA is the inhibitory synaptic transmitter of the vestibular neurons projecting to trochlear and other ocular motoneurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239109
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Role of γ-aminobutyric acid (GABA) in the extrapyramidal motor system (1971)
    Springer
    Experimental brain research 14 (1971), S. 95-104 
    Details
    ISSN: 1432-1106
    Keywords: GABA ; Strio-nigral neurons ; Elongated synaptic vesicles ; Hemitransection ; Bouton-degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interference with the neuronal connection between the substantia nigra and striatum of rat by hemitransection at the subthalamic level or lesion of left side of striatum by a simple suction method was studied in relation to the concentration of γ-aminobutyric acid (GABA) in both regions. Time interval studies, at two, six, and twelve days after hemitransection, showed that the GABA concentration in substantia nigra had markedly decreased, whereas only a slight change was shown on the striatum of the operated side. Destruction of the striatum by suction caused a significant fall of the GABA content in the ipsilateral side of substantia nigra. However, destruction of the frontal cortex alone did not cause any marked change in the GABA content of the substantia nigra. In addition, electron microscopic studies disclosed that within the synaptic organization of the substantia nigra approximately 20 % of the boutons contained elongated synaptic vesicles, and that, following coagulation of the striatum, some large axosomatic terminals containing elongated synaptic vesicles also underwent degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234913
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...