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  • Articles: DFG German National Licenses  (3)
  • 1990-1994  (3)
  • 1955-1959
  • Bulge  (1)
  • Children  (1)
  • Gas chromatography  (1)
Source
  • Articles: DFG German National Licenses  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    A high concentration of Merkel cells in the bulge prior to the attachment of the arrector pili muscle and the formation of the perifollicular nerve plexus in human fetal skin (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 261-268 
    Details
    ISSN: 1432-069X
    Keywords: Merkel cell ; Bulge ; Arrector pili muscle ; Nerve plexus ; Skin development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution of Merkel cells in human fetal hair follicles was studied using whole mounts of separated epidermis with attached hair follicles. The technique had the advantage of enabling the elucidation of the spatial relationships of Merkel cells with other cells in the skin. In a 16-week-old fetus the hair anlagen had formed one or two epithelial swellings of variable size. In a 17-week-old fetus sebaceous glands and the bulge of the hair follicle were recognizable and immunoreactive Merkel cells were present in the bulge and surrounding the acrotrichium (intraepidermal follicular canal). In a 20-week-old fetus the sebaceous gland and bulge were well formed and immunoreactive Merkel cells were concentrated in the bulge and infundibulum. In vertical sections of a 20-week-old fetus immunoreactive Merkel cells were also situated in the vicinity of the bulge. Arrector pili muscles were first observable in a 24-week-old fetus being weakly stained with anti-desmin antibody. In a 24-week-old fetus, nerves were also stained within the arrector pili muscles with S-100 protein antibody. In the presumptive arrector pili muscle immunoreactivity for S-100 protein developed before or at the same time as immunoreactivity for desmin. Merkel cells or their products in the bulge may serve as attractants for the growing arrector pili muscle which contain peripheral nerves. Following our report that dermal Merkel cells influence the formation of the dermal nerve plexus, perifollicular Merkel cells near the bulge may also play an inductive and growth-stimulative role for the perifollicular nerve plexus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371594
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Biological monitoring of acrylonitrile exposure through a new analytical approach to hemoglobin and plasma protein adducts and urinary metabolites in rats and humans (1993)
    Springer
    International archives of occupational and environmental health 65 (1993), S. S103 
    Details
    ISSN: 1432-1246
    Keywords: Acrylonitrile ; Adducts ; Biological monitoring ; Gas chromatography ; Hemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new, simple and fast procedure of measuring acrylonitrile (ACN) in ACN derived mercapturic acids such as S-(2-cyanoethyl)-L-cysteine(CyEC), and in hemoglobin (Hb) and plasma protein adducts and urinary metabolites in rats and humans exposed to ACN was developed. ACN in mercapturic acids or proteins was analyzed by capillary gas chromatography (GC) by liberating ACN at a high-temperature in the injector port of GC with or without oxidizing sulfur atoms of the ACN-bound cysteines into sulfoxide form by hydrogen peroxide in vitro. At 350 °C, more than 90% of ACN in authentic CyEC was recovered by this method. Increasing a single ip dose of ACN from 5 to 50 mg/kg produced proportional increases in ACN bound to Hb 24 hr after the treatment. The alkylation of plasma protein with ACN was about 1/10 as low as that of Hb. After repeated daily ip doses of 1–10 mg/kg, ACN in Hb decreased with a half-life of about 9 days. ACN was also detected in the blood of workers exposed to ACN for 1 to 10 years at a Siberian synthetic rubber factory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381317
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Recurrent low-grade glioma in children with special reference to computed tomography findings and pathological changes (1990)
    Springer
    Child's nervous system 6 (1990), S. 155-160 
    Details
    ISSN: 1433-0350
    Keywords: Recurrence ; Low-grade glioma ; Children ; Malignant transformation ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recurrent low-grade gliomas in children were studied with special reference to correlation between the computed tomography (CT) scan and pathological findings at recurrence. During the past 16 years (1970–1986) 105 cases of primary pediatric brain tumors were treated in our hospital. Seventeen of these had low-grade glioma, seven of which (five astrocytomas, one ependymoma, and one subependymoma) had recurrence of tumor by the end of 1987. The enhanced CT findings were classified into three types — cystic, false cystic, and solid, according to Lapras' classification. The pathological findings of recurrent tumors were reviewed with particular attention to malignant transformation. The results showed that in two out of three cases where CT findings had changed from initial cystic to solid type at recurrence malignant transformation was revealed. Enhanced CT scan was also useful for detecting small asymptomatic recurrent tumors in children. On the other hand, surgical procedures and adjuvant therapies demonstrated no significant relationship with recurrence. It is suggested that the recurrence of low-grade glioma in children is not rare, and that changes in findings on contrast enhanced CT might reflect malignant transformation in a recurrent tumor, necessitating a careful follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308493
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    Paper (German National Licenses)
    Fulltext
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