ISSN:
1432-1459
Keywords:
Huntington's disease
;
Positron emission tomography
;
Regional cerebral glucose consumption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00870669
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