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  • 1
    Electronic Resource
    Electronic Resource
    Estimation of myocardial blood flow heterogeneity by transorgan helium transport functions (1984)
    Springer
    Pflügers Archiv 401 (1984), S. 217-222 
    Details
    ISSN: 1432-2013
    Keywords: Inert gas dilution method ; Deconvolution ; Circulatory transport function ; Indicator transit time ; Heterogeneity of myocardial blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following single breath inhalations of helium 49 simultaneous inlet-outlet pairs of helium dilution curves were recorded in seven dog experiments from the aortic and coronary sinus blood by use of mass spectrometric technique. After numeric deconvolution of the dilution curves the weighting function of tracer transit times was used for calculation of the mean myocardial blood flow per unit of tissue, which closely correlated with directly measured flow. Secondly, the degree of blood flow heterogeneity was estimated from the first moments of the weighting function of transit times and by compartmental analysis based on an inverse Laplace transform. In the intact heart the results suggest a rather constant dispersion of flows relative to the mean flowFF in the order of σ/FF=0.3. The apparent dispersion of flows is increased by α-adrenergic stimulation with pressure and volume load, particularly in a state of β-blockade, a finding, which may be attributed to variations of intercapillary distances and to a heterogeneity of blood flow per unit of tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582586
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behandlung des hyperkinetischen Herzsyndroms mit Alinidine und Propranolol (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 69-75 
    Details
    ISSN: 1432-1440
    Keywords: Hyperkinetic heart syndrome ; Bradycardic drugs ; Alinidine (ST 567) ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A hyperkinetic heart syndrome has been diagnosed in 10 patients by clinical investigation and right-heart catheterization at rest and during exercise. Subsequently, the patients received 3×40 mg alinidine, and 2×40 mg propranolol and placebo, each for 2 weeks in a double-blind cross-over study. Heart rate at rest (P〈0.05) and during exercise (P〈0.001) decreased significantly under alinidine and propranolol to the same extent (control, 83/170; alinidine, 68/146; propranolol, 73/139; placebo, 83/162 beats per min). Lower limb flow at rest and after exercise, measured by plethysmography, as well as left-ventricular fractional shortening and mean velocity of circumferential fiber shortening, measured by echocardiography, decreased insignificantly. Sedation and a dry mouth occurred in six patients under alinidine, while fatigue and cold hands and/or feet were reported by five patients under propranolol. Thus, alinidine may be used as an alternative to beta-blocking in the treatment of the hyperkinetic heart syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745476
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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