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  • Key words: Kushiro-oki earthquake, viscoelastic, 3-D FEM, displacement and stress fields, coseis mic, postseismic.  (1)
  • Physical dependence  (1)
  • Redox state  (1)
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Pure and applied geophysics 152 (1998), S. 443-464 
    ISSN: 1420-9136
    Schlagwort(e): Key words: Kushiro-oki earthquake, viscoelastic, 3-D FEM, displacement and stress fields, coseis mic, postseismic.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract —We constructed a three-dimensional finite element model to simulate coseismic and postseismic displacement and stress fields associated with the 1993 Kushiro-oki earthquake, which was a very large intermediate-depth earthquake that occurred within the subducted Pacific plate at a depth of 107 km beneath the southeastern part of Hokkaido, Japan. Taking the configuration of the subducted Pacific plate into account, we constructed a realistic model with lateral heterogeneity of viscoelastic structure. We assigned a variable slip distribution to the fault plane, which was obtained from inversion analysis of near-field seismic waveforms. The result shows that elastic deformation associated with the faulting reflects the assigned inhomogeneous slip distribution on the fault plane near the fault region, while it does not reflect the distribution on the free surface of the model. The calculated postseismic deformation does not reflect the slip distribution, but shows symmetric spatial patterns concerning the dipping direction of the fault both near the fault region and on the model surface. For the next 20 years following the earthquake, the amount of the calculated deformation is a fraction of the coseismic deformation. The calculated coeseismic deformation is large just above and below the fault plane, reaching 1 m, while the postseismic deformation is dominant near the upper and lower material boundaries between the subducted plate and the surrounding asthenosphere. The spatial distribution of maximum shear stress near the fault plane corresponds to the assigned slip distribution, amounting to 32 MPa. The directions of principal stress-change axes represent reverse fault type in the SSE region of the fault, whereas normal fault type is dominant in the NNW region with the exception of some asymmetrical spatial patterns of the principal stress-change axes on the fault due to the inhomogeneous slip distribution. Time variations both in the amount and the directions of stresses are minor, suggesting that the coseismic state of the stress would remain unchanged for two decades after the event.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-2072
    Schlagwort(e): Intravenous infusion ; Body weight loss ; Morphine ; Meperidine ; Physical dependence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract An intravenous infusion method is described for rapidly producing physical dependence in rats. Rats were infused with morphine or meperidine for 24 or 48 h at constant rates and the development of physical dependence was assessed by body weight loss after naloxone challenge. Naloxone challenge induced body weight losses that were dependent upon magnitude, rate and duration of infusion. The steady-state concentrations of morphine (4 mg/kg/h) in serum and meperidine (6 mg/kg/h) in plasma were 4 and 2.5 μg/ml, respectively. Morphine concentration in the brain in the steady-state (4 mg/kg/h) was 0.7 μg/g and in the serum was proportional to the infusion rate. Maximum body weight loss was significantly correlated with total amount of infused morphine, but not with the steady-state concentration of the drug in the serum. These results suggest that total doses of infused morphine, not steady-state concentrations, are critical in producing body weight loss.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1433-8580
    Schlagwort(e): Rat ; Liver cirrhosis ; Hypoxia ; Redox state ; Mitochondrial oxidative phosphorylative activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The influence of hypoxia on hepatic mitochondrial function and energy status was studied in normal and carbon tetrachloride (CCl4)-induced cirrhotic rats. Under hypoxemia of 50 mm Hg-PaO2, hepatic energy status was suppressed both in normal and cirrhotic rats. After the reversal of hypoxia, it was completely restored in normal rats concomitant with a rapid elevation of hepatic mitochondrial redox state (overshoot phenomenon) and increase in the mitochondrial oxidative phosphorylative activity. By contrast, in cirrhotic rats, such an enhancement of mitochondrial function was not observed. It was clarified that cirrhotic liver mitochondria have little capacity to respond to the hypoxic stress. A lower resistance to hypoxic episode in cirrhotics might be attributable to the absence of mitochondrial enhancement which is a compensatory mechanism for the deranged energy metabolism of the liver.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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