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  • Local Tetanus  (2)
  • Local tetanus  (2)
  • Alkylating agents  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Roles of two types of O^6-methylguanine-DNA methyltransferases in DNA repair
    Amsterdam : Elsevier
    Mutation Research/DNA Repair 254 (1991), S. 37-44 
    Details
    ISSN: 0921-8777
    Keywords: Alkylating agents ; Cell survival ; DNA repair ; Mutation frequency ; O^6-Methylguanine-DNA methyltransferase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8777(91)90038-Q
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tension-extension diagram of the tetanus-intoxicated muscle of the cat (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 276 (1973), S. 421-436 
    Details
    ISSN: 1432-1912
    Keywords: Local Tetanus ; Stretch Reflex ; Tension-Extension Curve ; Gamma Bias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Tetanus toxin was injected into one triceps surae muscle of the cat to obtain symptoms of local tetanus. The contralateral homologous muscle was used as a control. 2. The incubation time (20–40 h) was linearly related to the cube root of the weight of cat and showed a constant velocity (7–9 mm/h) of the spreading of toxin in the nerve fibres in cats of various sizes. 3. The tension-extension curves of the tetanus muscle showed more stiffness and the base of the exponential passive tension-extension curve was always greater in the tetanus triceps surae muscle than in the control. 4. With repeated stretches of the poisoned muscle the total tension-extension curve showed a progressive parallel shift to the right, indicating threshold increase of the stretch reflex. With antagonistic nerve stimulation the curve shiftet to the left (facilitation), which was never seen in the normal state. 5. The total tension-extension curve of the poisoned muscle showed a progressive parallel shift to the left during the first few hours after the onset of symptoms, and to the right during selective blocking of the gamma fibres by procaine. 6. The cats in which the toxin was injected into the flexor (tibialis anterior) muscle, had a longer incubation time and developed extensor spasticity instead of flexion of the leg. 7. It is concluded that bias augmentation of the extensor gamma system is mainly responsible for the muscular stiffness in the early period of local tetanus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499895
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of tetanus toxin on the monosynaptic reflex (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 323 (1983), S. 217-220 
    Details
    ISSN: 1432-1912
    Keywords: Tetanus toxin ; Local tetanus ; Spinal cord ; Monosynaptic reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tetanus toxin was injected at various doses (0.1–10,000 mouse MLD/kg) into the gastrocnemius muscle of the left hind leg of the cat. The relative excitability of the monosynaptic reflex (MSR) was increased in the very early period of the intoxication decreased in the later period, during which the MSR of the gastrocnemius was either partially or totally depressed at doses as low as 10 mouse MLD/kg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497666
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Gamma-bias of the muscle poisoned by tetanus toxin (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 276 (1973), S. 413-420 
    Details
    ISSN: 1432-1912
    Keywords: Tetanus Intoxication ; Local Tetanus ; Pathological Gamma-Bias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Local tetanus in the right hind leg of the cat was caused by injecting tetanus toxin subcutaneously at the right triceps surae muscle. The left side, which showed no pathological symptoms, was used as control. 2. The muscles of both sides were stretched linearly at a very slow rate (0.02 to 0.2 mm/sec). We compared the electrical mass activity of the bundle from dorsal roots L7 and S1 in response to muscle stretch of the control and the pathological side. 3. Both before and during the linear stretching the afferent activity was stronger on the intoxicated than on the control side. 4. It is concluded that during local tetanus the rough pathological augmentation of the basis in the gamma system was about 10 mm or more, and that the change of the gamma bias in the intoxicated preparation is beyond the physiological range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499894
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Tetanus toxin induced actions on spinal Renshaw cells and Ia-inhibitory interneurones during development of local tetanus in the cat (1977)
    Springer
    Experimental brain research 27 (1977), S. 271-286 
    Details
    ISSN: 1432-1106
    Keywords: Local tetanus ; Spinal interneurones ; Spinal inhibitions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats the activities of Renshaw cells (RCs) and Ia-inhibitory interneurones (IaINs) were recorded during the accumulation of tetanus toxin in the spinal cord following injection into the gastrocnemius muscle. The early response of the RCs increased during the period of development of local tetanus. With some cells there was a subsequent decrease in the early response in later periods of the observation time (16–44 hrs after intramuscular injection). The effects on the spontaneous activity of the RCs were in good correspondence to those on the early response. The hyperactivity of the RCs is proposed to be mediated mainly via disinhibited cholinergic gamma-motoneurones using muscarinic postsynaptic receptors. The “pause” which follows the early response and the recurrent inhibition of IaINs was not reduced during the development of local tetanus. These results indicate that the central action of tetanus toxin in local tetanus does not consist of a general loss of postsynaptic inhibition. It is suggested that tetanus toxin acts mainly on synaptic elements of the alpha- and gamma-motoneurones or on presynaptic nerve terminals in their vicinity. In later periods a disturbing influence on the cholinergic transmission at Renshaw cells seems to occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235503
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    Paper (German National Licenses)
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