ISSN:
1432-1440
Keywords:
125J-fibrinogen uptake test
;
Venous thrombosis
;
Anticoagulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The sensitivity of the radiofibrinogen test was investigated to determine the accuracy of the test in diagnosis of venographically proven venous thrombosis in 70 heparinized patients.125J-fibrinogen was administered between 2 h and 4 days (mean: 1.5 days) after initiating heparin therapy. There were two criteria for a positive test: (a) if the difference between the counts for adjacent points on the same leg or equivalent sites on opposite legs was at least 15%; and/or (b) if there were three adjacent points each with counts 〉5% that of the same three points on the other leg. The fibrinogen uptake test was positive at the first examination in 67 of 70 patients, giving a sensitivity of 96%. The respective frequencies of truly abnormal results for the 3×5% and the 1×15% criteria were 94% and 71%. As far as localization and extension of thrombosis were concerned, the fibrinogen uptake test agreed with phlebography in 73% of the cases, when the counts in the groin and the upper third of the thigh were ignored. The125J-fibrinogen uptake test is an accurate method for detecting established deep leg vein thrombosis even in anticoagulated patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01711653
Permalink
