ISSN:
1432-0533
Keywords:
Malignant gliomas
;
Allelic delection
;
Restriction fragment length polymorphisms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Gene delection of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytome cases. One glioblastoma case showed loss of heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue. The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294641
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