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  • 1
    ISSN: 1432-1238
    Keywords: Diagnostic techniques ; Mechanical ventilation ; Nosocomial pneumonia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Key words Arterial lactate ; Mechanical ventilation ; Respiratory failure ; Arterial hypotension ; Respiratory mechanics ; Work of breathing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To determine whether mechanical ventilation (MV) may affect blood lactate concentration in patients with acute respiratory failure. Design: Prospective observational study with follow-up to hospital discharge. Setting: A 17-bed medical and coronary intensive care unit in a 650-bed general hospital. Patients: 55 adult patients mechanically ventilated for acute respiratory failure between May 1996 and April 1997 were recruited. Measurements and results: Arterial blood samples for determination of plasma lactate and blood gas analysis were taken just before tracheal intubation on spontaneous breathing, and 20 and 60 min after the initiation of controlled MV. Cuff systemic arterial pressure was measured before tracheal intubation and every 10 min during the first h of MV. Hyperlactatemia (arterial blood lactate ≥ 2 mmol/l) was present in 21 of the 55 patients studied. After 20 min of MV, there was a decrease in blood lactate from 4.74 ± 1.78 to 3.07 ± 1.69 mmol/l (p 〈 0.01); 40 min later there was a further decrease to 2.63 ± 1.35 mmol/l (p 〈 0.05). The decrease in blood lactate was also observed in those patients who after starting MV developed systemic arterial hypotension (p 〈 0.01). In patients with a normal lactate concentration at the entry to the study, lactate remained the same after 60 min on MV (NS). Conclusions: Controlled MV decreases substantially the severity of hyperlactatemia in patients with acute respiratory failure, and any adverse circulatory effects of MV do not alter this beneficial outcome.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The best yields and productivities of 0.38 g · g-1 and 0.35 g · l-1 h-1, respectively, for the propionic acid production in a batchsystem using sugar-cane final molasses as carbon source were obtained when an initial TRS concentration of 50 g · l-1 was used.It was obvious that this process is severely inhibited by the acids produced and the most drastic effect (μ = 0) was at a TVA concentration near to 250 mmol · l-1, independently of the initial TRS concentration employed.A generalizated equation of noncompetitive inhibition was adjusted: \documentclass{article}\pagestyle{empty}\begin{document}$$\mu = \frac{{\mu _{\max } }}{{1 + \left( {\frac{{TVA}}{{K_{\rm P} }}} \right)^n }}$$\end{document} and kinetic inhibition constants for each initial TRS concentration studied were estimated.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Growth inhibition of Candida utilis NRRL Y-660 took place in molasses stored at 60°C for 120 days. The specific growth rate (μmax) was reduced from 0.42 h-1 to 0.200 h-1 as a result of a lack of affinity from the microorganism to the substrate and the increasing maintenance necessities. The Ks values arose from 1.40 mg/ml to 4.28 mg/ml within the whole experiment. At the same time, the maintenance coefficient (m) increased from 0.250 to 3.80 mg/ml. In a continuous culture the “wash-out” conditions were reached at dilution rate values (D) close to 0.40 h-1. The process productivity decreased up to 15% from its original value in fresh molasses.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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