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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 103 (1968), S. 277-284 
    ISSN: 1432-1076
    Keywords: Meningokokkenmeningitis ; Meningokokkensepsis ; Defektzustände
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden 200 Kinder im Alter von 2–171/2 Jahren nach einer in den Jahren 1955–1966 abgelaufenen Meningokokkenmeningitis und-sepsis eingehend nachuntersucht. Die Probanden wurden einer ausführlichen klinisch-neurologischen Untersuchung, einer Elektrencephalographie, Echoencephalographie und einem Kramer-Intelligenztest unterzogen. Dabei fanden sich bei 39,5% restlose Heilungen, bei 35% leichte und bei 19,5% schwerere Restschäden. Mit zunehmendem Alter der Kinder verringerten sich die schweren Spätschäden. Die restlichen 6% ließen nicht ausschließen, daß der zentral-nervöse Schaden nicht schon vor der Meningitis bestand bzw. nur eine Verschlimmerung durch die Erkrankung erfuhr. Da es sich um Nachuntersuchungen bei Überlebenden aus zum Teil entfernten Gegenden handelt, liegen keine Zahlen über die Letalität in dieser Zeit vor.
    Notes: Summary 200 children of 2 to 171/2 years of age who have had a meningococcal meningitis or -sepsis in 1955–1966 have been reexamined. The patients were submitted to an extensive neurological examination with electroencephalography and echoencephalography and a Kramer-intelligencetest. 39,5% of the patients were found to be completely cured, 35% had mild, 19,5% had severe residual damage. With increasing age of the children the severe damage lessened. In 6% of the patients a preexistent cerebral damage which was aggravated by the meningitis could not be ruled out. Letality numbers during this time could not be established as the surviving patients came out of distant areas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Apoptosis 5 (2000), S. 319-322 
    ISSN: 1573-675X
    Keywords: aminodipeptidase ; caspase ; quiescence ; quiescent cell proline dipeptidase ; proteasome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We recently isolated and cloned an intracellular post-proline cleaving aminodipeptidase, quiescent cell proline dipeptidase (QPP), which has a substrate specificity very similar to that of dipeptidyl peptidase IV (CD26/DPPIV). Highly specific inhibitors of proline aminodipeptidases activate a novel apoptotic pathway in quiescent lymphocytes. The target of these inhibitors is not CD26/DPPIV, but appears to be QPP. The apoptosis pathway induced by the aminodipeptidase inhibitors is unusual in that it is restricted to quiescent lymphocytes, but not activated or transformed lymphocytes. The caspases activated in this apoptotic pathway are different from those activated in Fas or gamma-irradiation mediated cell death pathways, and furthermore, the proteasome appears to play a role in this death pathway. A large number of signal molecules including chemokines and cytokines have a highly conserved X-Pro motif on the N-terminus, rendering them potential substrates of QPP and players in the survival of resting lymphocytes.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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