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  • 1
    Electronic Resource
    Electronic Resource
    Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: Evidence for dopaminergic supersensitivity in protracted abstinence (1974)
    Springer
    Psychopharmacology 34 (1974), S. 37-44 
    Details
    ISSN: 1432-2072
    Keywords: Aggression ; Morphine Addiction ; Apomorphine ; Dopamine Receptors ; Receptor Supersensitivity ; Narcotic Abstinence ; Nigrostriatal Lesion ; Medial Forebrain Bundle Lesion ; Protracted Abstinence ; Dopamine Turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reliable aggression was seen in rats which were grouped 30 days after undergoing continuous withdrawal from morphine. This withdrawal aggression, associated with long-lasting effects of morphine dependence, was blocked by morphine or lesions of the nigrostriatal bundle, but not by lesions of the median forebrain bundle. When the nigrostriatal lesioned rats were treated with a small dose of apomorphine, the aggression was reinstated. Apomorphine reduced the turnover of dopamine in the 30-day withdrawn rats at doses which were ineffective in similarly housed non-dependent rats. These results suggest that animals undergoing protracted morphine abstinence show aggression due to a latent dopaminergic supersensitivity, similar to that previously reported during acute narcotic withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421218
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties (1972)
    Springer
    Psychopharmacology 26 (1972), S. 313-316 
    Details
    ISSN: 1432-2072
    Keywords: LSD ; Mescaline ; Psilocybin ; State-Dependent Learning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to choose between the arms of a T-maze apparatus according to whether they were injected i.p. with 0.1 Μmol/kg LSD or 0.9% saline. The LSD drug-state acquired the properties of a discriminative stimulus, possibly by producing interoceptive cues. Doses of 9.0 Μmol/kg psilocybin and 90 and 120 Μmol/kg mescaline produced cueing effects which were not significantly different from the cueing effect of LSD. However, d-amphetamine (14.8 and 29.6 Μmol/kg) did not appear to produce an LSD-like cue. These results suggest that LSD, mescaline and psilocybin, when administered in functionally equivalent doses, produce qualitatively similar interoceptive cues in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422707
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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