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  • 1
    Electronic Resource
    Electronic Resource
    Die Differenzierung menschlicher Blutlymphocyten mit immunologischen und autoradiographischen Methoden (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 504-509 
    Details
    ISSN: 1432-1440
    Keywords: Lymphocytes ; Subpopulations ; Chronic lymphocytic leukaemia ; Lymphocyten ; Subpopulationen ; Chronische Lymphadenose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zirkulierende Lymphocyten setzen sich aus funktionell heterogenen Zellen zusammen, welche mit morphologischen Methoden allein nur ungenügend differenziert werden können. Unter Verwendung immunologischer und autoradiographischer Methoden wurden Lymphocyten mit Determinanten leichter (kappa) Ketten, Lymphocyten mit Membranreceptoren für Immun-Komplement-Komplexe, lymphatische Zellen mit cytoplasmatischem Immunglobulingehalt und Lymphocyten in DNS-Synthese bestimmt. Gegenüber Normalpersonen waren bei Patienten mit chronischer Lymphadenose Abweichungen an mehreren dieser Lymphocytenpopulationen nachweisbar. Die Ergebnisse werden im Hinblick auf das Konzept thymus- und knochenmarkabhängiger Lymphocyten diskutiert, deren Differenzierung mit immunologischen Methoden erleichtert wird.
    Notes: Summary Circulating lymphocytes consist of a heterogenous cell population. Employing immunological and autoradiographic methods lymphocytes with Ig (kappa) determinants, those with membrane receptors for immune-complement complexes, lymphocytes containing Ig intracellularly and those in DNA synthesis were evaluated in normals and in patients with chronic lymphocytic leukaemia (CLL). The concept of functionally defective lymphocytes in CLL was further substantiated. The use of immunological markers for identifying thymus (T)- and bone marrow (B) derived human lymphocytes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487294
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antikörper gegen autologe Lymphocyten bei Lupus erythematodes (LE) (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 484-486 
    Details
    ISSN: 1432-1440
    Keywords: Cytotoxic antibodies ; Lymphocytes ; Lupus erythematosus ; Cytotoxische Antikörper ; Lymphocyten ; Lupus erythematodes ; Autoantikörper
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seren von Patienten mit Lupus erythematodes, mit primär chronischer Polyarthritis, mit lymphoproliferativen Erkrankungen sowie verschiedenen Erkrankungen mit antinucleären Antikörpern wurden auf das Vorhandensein von Antikörpern gegen autologe Lymphocyten, sog. „Lymphocytotoxine“ getestet. Diese Lymphocytotoxine konnten fast ausschließlich bei Patienten mit LE nachgewiesen werden. Von 12 Patienten mit LE fehlten diese Antikörper nur in einem Fall. Ihr Auftreten war unabhängig von der Aktivität der Erkrankung. Die Virusätologie als Ursache der Entstehung des LE wird diskutiert.
    Notes: Summary Sera of patients suffering from Lupus erythematosus (LE), rheumatoid arthritis, lymphoproliferative disorders and various diseases with a high incidence of antinuclear antibodies were investigated with regard to antibodies against autologous lymphocytes, the so called “lymphocytotoxins”. These lymphocytotoxins were detected almost exclusively in patients with LE. They were present in 11 of 12 patients with LE in active as well as in successfully treated cases. The etiology of the disease is discussed in the light of these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487608
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Early detection of minimal residual disease by reverse transcriptase polymerase chain reaction predicts relapse in acute promyelocytic leukemia (1995)
    Springer
    Annals of hematology 70 (1995), S. 75-78 
    Details
    ISSN: 1432-0584
    Keywords: Acute promyelocytic leukemia ; Reverse transcriptase polymerase chain reaction ; Minimal residual disease ; Promyelocytic leukemia ; Retinoic acid receptorα
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The PML/RARα fusion RNA can be detected in acute promyelocytic leukemia (APL), cytogenetically characterized by the translocation t(15; 17). Our study included ten newly diagnosed patients with APL who were investigated during the course of their diseases using reverse transcription polymerase chain reaction (RT-PCR). At diagnosis, aberrant fragments with a size heterogeneity due to alternative spliced products were detected in all patients, we observed breakpoints within bcr3 (short type) in two patients and bcr1 and 2 breakpoints (long type) in eight patients. Treatment consisted of all-trans retinoic acid (ATRA) in all patients; six patients received simultaneous cytostatic therapy during remission induction. At the time of complete hematological remission (CR), only two patients showed a negative RT-PCR result; eight of the ten patients were still PCR positive when nested primers were used. Subsequently, eight patients received consolidation chemotherapy and became PCR negative. Seven of eight patients are in continuous complete remission (median remission duration: 21 months, range: 11+−26+ months). One patient of the chemotherapy group became PCR positive after 4 months in complete remission and relapsed after 6 months. The remaining two patients who were treated only with ATRA relapsed, received induction chemotherapy, and are in second and third complete remission, respectively. In conclusion, PCR negativity can be achieved only by chemotherapeutic consolidation; patients treated with ATRA alone remain PCR positive. Relapse is always preceded by a positive PCR result. Surprisingly, also patients without measurable PML/ RARα-mRNA in sequential analyses after cytostatic treatment became PCR positive and experienced relapse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834383
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Early detection of minimal residual disease by reverse transcriptase polymerase chain reaction predicts relapse in acute promyelocytic leukemia (1995)
    Springer
    Annals of hematology 70 (1995), S. 75-78 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute promyelocytic leukemia ; Reverse transcriptase polymerase chain reaction ; Minimal residual disease ; Promyelocytic leukemia ; Retinoic acid receptor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The PML/RARα fusion RNA can be detected in acute promyelocytic leukemia (APL), cytogenetically characterized by the translocation t(15; 17). Our study included ten newly diagnosed patients with APL who were investigated during the course of their diseases using reverse transcription polymerase chain reaction (RT-PCR). At diagnosis, aberrant fragments with a size heterogeneity due to alternative spliced products were detected in all patients, we observed breakpoints within bcr3 (short type) in two patients and bcr1 and 2 breakpoints (long type) in eight patients. Treatment consisted of all-trans retinoic acid (ATRA) in all patients; six patients received simultaneous cytostatic therapy during remission induction. At the time of complete hematological remission (CR), only two patients showed a negative RT-PCR result; eight of the ten patients were still PCR positive when nested primers were used. Subsequently, eight patients received consolidation chemotherapy and became PCR negative. Seven of eight patients are in continuous complete remission (median remission duration: 21 months, range: 11+–26+ months). One patient of the chemotherapy group became PCR positive after 4 months in complete remission and relapsed after 6 months. The remaining two patients who were treated only with ATRA relapsed, received induction chemotherapy, and are in second and third complete remission, respectively. In conclusion, PCR negativity can be achieved only by chemotherapeutic consolidation; patients treated with ATRA alone remain PCR positive. Relapse is always preceded by a positive PCR result. Surprisingly, also patients without measurable PML/RARα-mRNA in sequential analyses after cytostatic treatment became PCR positive and experienced relapse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834383
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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