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Clinical pharmacological studies of tandamine, a potential antidepressive drug (1977)

Ehsanullah, Raihana S. B. ; Ghose, Karabi ; Kirby, Marilyn J. ; [et al.]

Springer

Psychopharmacology 52 (1977), S. 73-77

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ISSN: 1432-2072

Keywords: Tandamine ; Tyramine pressor response ; Anticholinergic ; Appetite ; Sedation ; Depression ; Platelet ; Plasma concentration ; Monoamines

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00426603

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A Rapid, Accurate Technique for Determining Densities of High Explosives (1977)

Lagus, P. L. ; Turner, P. L. ; Gaffney, E. S.

Weinheim : Wiley-Blackwell

Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84

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ISSN: 0721-3115

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.

Additional Material: 2 Ill.