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  • acetylation  (2)
  • N-acetylation  (1)
  • PGF 1 α  (1)
  • 1
    Digitale Medien
    Digitale Medien
    The acute renal haemodynamic and endocrine response to felodipine in normal man (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 581-585 
    Details
    ISSN: 1432-1041
    Schlagwort(e): felodipine ; calcium antagonists ; renal haemodynamics ; prostaglandins ; kallikrein ; PGF 1 α
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment. Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate. There was no significant change in urinary 6 keto PGF 1 α or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine. The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542491
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the Rat (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 477-480 
    Details
    ISSN: 1573-904X
    Schlagwort(e): acetylation ; immunomodulators ; interferon inducers ; pharmacokinetics ; procainamide ; tilorone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Interferon and interferon inducers have been found to inhibit cytochrome P-450-dependent metabolism in animals and man. The effect of these agents on the acetylation of drugs has not been previously reported. Since these agents stimulate the reticuloendothelial system, together with the abundance of N-acetyltransferase in the reticuloendothelial system, it was hypothesized that these immunomodulators may affect drug acetylation. To test this hypothesis, the effect of tilorone (a synthetic interferon inducer) on the in vivo acetylation of procainamide was examined in the rat. Pretreatment with tilorone hydrochloride (50 mg/kg) 48 hr prior to the administration of procainamide hydrochloride (50 mg/kg) resulted in a 32% increase in the urinary recovery of N-acetylprocainamide and a 35% increase in the metabolic clearance of procainamide to N-acetylprocainamide. These data indicate that interferon inducers increase the N-acetylation of drugs in vivo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015964306318
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Disposition of Sulfamethazine and N-Acetylsulfamethazine in the Rat (1991)
    Springer
    Pharmaceutical research 8 (1991), S. 1069-1070 
    Details
    ISSN: 1573-904X
    Schlagwort(e): acetylation ; N-acetylation ; pharmacokinetics ; sulfamethazine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015877612600
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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